{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:31:16Z","timestamp":1786995076242,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.numecd.2021.02.018","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T22:18:31Z","timestamp":1614205111000},"page":"1822-1831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"31","author":[{"given":"Dan-Qin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-2631","authenticated-orcid":false,"given":"Ming-Hua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2021.02.018_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41575-019-0239-2","article-title":"What's new in NAFLD pathogenesis, biomarkers and treatment?","volume":"17","author":"Byrne","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.numecd.2021.02.018_bib2","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1097\/CM9.0000000000000989","article-title":"Non-invasive fibrosis assessment in non-alcoholic fatty liver disease","volume":"133","author":"Rios","year":"2020","journal-title":"Chin Med J"},{"key":"10.1016\/j.numecd.2021.02.018_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrneph.2017.16","article-title":"Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease","volume":"13","author":"Targher","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.numecd.2021.02.018_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.diabet.2019.11.003","article-title":"Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD","volume":"46","author":"Sun","year":"2020","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.numecd.2021.02.018_bib5","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/jgh.14894","article-title":"Effect of PNPLA3 polymorphism on diagnostic performance of various noninvasive markers for diagnosing and staging nonalcoholic fatty liver disease","volume":"35","author":"Liu","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.numecd.2021.02.018_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s00125-018-4805-x","article-title":"The PNPLA3 rs738409 C>G variant interacts with changes in body weight over time to aggravate liver steatosis, but reduces the risk of incident type 2 diabetes","volume":"62","author":"Xia","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2021.02.018_bib7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/apt.15372","article-title":"The PNPLA3 rs738409 C>G variant influences the association between low skeletal muscle mass and NAFLD: the Shanghai Changfeng Study","volume":"50","author":"Xia","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.numecd.2021.02.018_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2019.12.002","article-title":"Leveraging human genetics to identify potential new treatments for fatty liver disease","volume":"31","author":"Romeo","year":"2020","journal-title":"Cell Metabol"},{"key":"10.1016\/j.numecd.2021.02.018_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/liv.14251","article-title":"PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels","volume":"40","author":"Sun","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.numecd.2021.02.018_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132158","article-title":"Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease","volume":"5","author":"Luukkonen","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.numecd.2021.02.018_bib11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/hep.31229","article-title":"Genetic pathways in nonalcoholic fatty liver disease: insights from systems biology","volume":"72","author":"Sookoian","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.numecd.2021.02.018_bib12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.18388\/abp.2007_3289","article-title":"Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase\/reductase 9","volume":"54","author":"Liu","year":"2007","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.numecd.2021.02.018_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2018.10.014","article-title":"Role of HSD17B13 in the liver physiology and pathophysiology","volume":"489","author":"Su","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.numecd.2021.02.018_bib14","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1073\/pnas.1410741111","article-title":"Comparative proteomic study reveals 17 beta-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease","volume":"111","author":"Su","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.numecd.2021.02.018_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/hep.30799","article-title":"High risk of fatty liver disease amplifies the alanine transaminase-lowering effect of a HSD17B13 variant","volume":"71","author":"Gellert-Kristensen","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.numecd.2021.02.018_bib16","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3748\/wjg.v26.i36.5474","article-title":"Pediatric non-alcoholic fatty liver disease and kidney function: effect of HSD17B13 variant","volume":"26","author":"Di Sessa","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.numecd.2021.02.018_bib17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1681\/ASN.2018111166","article-title":"Changes in albuminuria but not GFR are associated with early changes in kidney structure in type 2 diabetes","volume":"30","author":"Looker","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.numecd.2021.02.018_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4939-9488-5_17","article-title":"Detection and quantification of lipid droplets in differentiated human podocytes","volume":"1996","author":"Mallela","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.numecd.2021.02.018_bib19","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1042\/CS20180702","article-title":"Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease","volume":"132","author":"Yang","year":"2018","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.numecd.2021.02.018_bib20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.kint.2018.06.031","article-title":"Hydroxypropyl-beta-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis","volume":"94","author":"Mitrofanova","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2021.02.018_bib21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-981-13-8871-2_26","article-title":"Lipid metabolism disorder and renal fibrosis","volume":"1165","author":"Du","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.numecd.2021.02.018_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.numecd.2021.02.018_bib23","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.numecd.2021.02.018_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2021.02.018_bib25","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1074\/jbc.RA118.002333","article-title":"Patatin-like phospholipase domain\u2013containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets","volume":"293","author":"Mitsche","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2021.02.018_bib26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2020.01.013","article-title":"NAFLD as a driver of chronic kidney disease","volume":"72","author":"Byrne","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2021.02.018_bib27","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/liv.14419","article-title":"PNPLA3 I148M gene variant and chronic kidney disease in type 2 diabetic patients with NAFLD: clinical and experimental findings","volume":"40","author":"Mantovani","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.numecd.2021.02.018_bib28","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/hep.30350","article-title":"17-Beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease","volume":"69","author":"Ma","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.numecd.2021.02.018_bib29","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.cgh.2020.02.011","article-title":"Development and validation of a scoring system, based on genetic and clinical factors, to determine risk of steatohepatitis in Asian patients with nonalcoholic fatty liver disease","volume":"18","author":"Koo","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.numecd.2021.02.018_bib30","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/liv.14387","article-title":"Association of HSD17B13 rs72613567:TA with non-alcoholic fatty liver disease in Hispanics\/Latinos","volume":"40","author":"Kallwitz","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.numecd.2021.02.018_bib31","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","article-title":"A protein-truncating HSD17B13 variant and protection from chronic liver disease","volume":"378","author":"Abul-Husn","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2021.02.018_bib32","doi-asserted-by":"crossref","first-page":"F433","DOI":"10.1152\/ajprenal.00375.2015","article-title":"Systemic and renal lipids in kidney disease development and progression","volume":"310","author":"Wahl","year":"2016","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.numecd.2021.02.018_bib33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1046\/j.1523-1755.1999.00587.x","article-title":"Human mesangial cells express inducible macrophage scavenger receptor","volume":"56","author":"Ruan","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2021.02.018_bib34","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.clinbiochem.2009.05.010","article-title":"Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients","volume":"42","author":"Vasconcelos","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.numecd.2021.02.018_bib35","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1046\/j.1523-1755.1999.07113.x","article-title":"Effect of lipoproteins on mesangial cell proliferation","volume":"71","author":"Nishida","year":"1999","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.numecd.2021.02.018_bib36","first-page":"F937","article-title":"Transforming growth factor-beta expression in macrophages during hypercholesterolemic states","volume":"267","author":"Ding","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.numecd.2021.02.018_bib37","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrneph.2009.184","article-title":"An update on the lipid nephrotoxicity hypothesis","volume":"5","author":"Ruan","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.numecd.2021.02.018_bib38","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1172\/JCI0216452","article-title":"Consequences of cellular cholesterol accumulation: basic concepts and physiological implications","volume":"110","author":"Tabas","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2021.02.018_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrneph.2017.181","article-title":"Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease","volume":"14","author":"Carrero","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.numecd.2021.02.018_bib40","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.ajkd.2018.02.362","article-title":"Obesity, metabolic abnormality, and progression of CKD","volume":"72","author":"Yun","year":"2018","journal-title":"Am J Kidney Dis"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475321000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475321000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:16:15Z","timestamp":1760544975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475321000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0939475321000879"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2021.02.018","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2021.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}