{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:15:45Z","timestamp":1790799345391,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.numecd.2022.06.017","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T02:10:37Z","timestamp":1656555037000},"page":"2246-2254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-3884","authenticated-orcid":false,"given":"A.F.G.","family":"Cicero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-0042","authenticated-orcid":false,"given":"F.","family":"Fogacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-4342","authenticated-orcid":false,"given":"S.","family":"D'Addato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.G.","family":"Cicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"D'Addato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fogacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Grandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ianniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Soldati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Piani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Iamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Landolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bacchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2022.06.017_bib1","series-title":"Hypertension fact sheet","author":"World Health Organization","year":"2019"},{"key":"10.1016\/j.numecd.2022.06.017_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40119-019-00159-1","article-title":"Facing the challenge of lowering blood pressure and cholesterol in the same patient: report of a symposium at the European society of hypertension","volume":"9","author":"Williams","year":"2020","journal-title":"Cardiol Ther"},{"key":"10.1016\/j.numecd.2022.06.017_bib3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2022.06.017_bib4","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1093\/pubmed\/fdy088","article-title":"Adherence to cardiovascular medication: a review of systematic reviews","volume":"41","author":"Leslie","year":"2018","journal-title":"J Public Health"},{"key":"10.1016\/j.numecd.2022.06.017_bib5","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s12325-019-01002-8","article-title":"Treatment of hypertensive and hypercholesterolaemic patients with the triple fixed combination of atorvastatin, perindopril and amlodipine: the results of the CORAL study","volume":"36","author":"Simon","year":"2019","journal-title":"Adv Ther"},{"key":"10.1016\/j.numecd.2022.06.017_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejim.2018.03.010","article-title":"Brisighella heart study group medical and surgical Sciences dept., university of Bologna. Fatty liver index is associated to pulse wave velocity in healthy subjects: data from the Brisighella heart study","volume":"53","author":"Cicero","year":"2018","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.numecd.2022.06.017_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejim.2016.08.018","article-title":"Serum lipoprotein(a) level as long-term predictor of cardiovascular mortality in a large sample of subjects in primary cardiovascular prevention: data from the Brisighella Heart Study","volume":"37","author":"Fogacci","year":"2017","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.numecd.2022.06.017_bib8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/jcm10040640","article-title":"Laboratory and instrumental risk factors associated with a sudden cardiac death prone ECG pattern in the general population: data from the Brisighella heart study","volume":"10","author":"Coppola","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.numecd.2022.06.017_bib9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/HJH.0000000000001927","article-title":"Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study","volume":"37","author":"Cicero","year":"2019","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2022.06.017_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/07853890.2016.1222451","article-title":"Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study","volume":"49","author":"Cicero","year":"2017","journal-title":"Ann Med"},{"key":"10.1016\/j.numecd.2022.06.017_bib11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2022.06.017_bib12","first-page":"zwab154","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"24","author":"Visseren","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2022.06.017_bib13","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2022.06.017_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2362.2009.02234.x","article-title":"A catalogue of reporting guidelines for health research","volume":"40","author":"Simera","year":"2010","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.numecd.2022.06.017_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.122.17956","article-title":"Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk","author":"Borghi","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2022.06.017_bib16","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1159\/000508280","article-title":"Effect of combined statin and antihypertensive therapy in patients with hypertension: a systematic review and meta-analysis","volume":"145","author":"Wang","year":"2020","journal-title":"Cardiology"},{"key":"10.1016\/j.numecd.2022.06.017_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s40292-019-00336-2","article-title":"Treatment with free triple combination therapy of atorvastatin, perindopril, amlodipine in hypertensive patients: a real-world population study in Italy","volume":"26","author":"Perrone","year":"2019","journal-title":"High Blood Pres Cardiovasc Prev"},{"key":"10.1016\/j.numecd.2022.06.017_bib18","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1097\/HJH.0000000000001419","article-title":"Favourable impact of statin use on diastolic blood pressure levels: analysis of a large database of 24-hour ambulatory blood pressure monitoring","volume":"35","author":"Tocci","year":"2017","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.numecd.2022.06.017_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40292-017-0184-5","article-title":"Impact of statin therapy on the blood pressure-lowering efficacy of a single-pill perindopril\/amlodipine combination in hypertensive patients with hypercholesterolemia","volume":"24","author":"Sirenko","year":"2017","journal-title":"High Blood Pres Cardiovasc Prev"},{"key":"10.1016\/j.numecd.2022.06.017_bib20","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/HJH.0000000000002276","article-title":"Statin therapy is associated with better ambulatory blood pressure control: a propensity score analysis","volume":"38","author":"Spannella","year":"2020","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2022.06.017_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2021.106900","article-title":"Comparative efficacy of fixed-dose statin and antihypertensive agent combinations: a network meta-analysis of randomized controlled trials","volume":"141","author":"Bellos","year":"2021","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.numecd.2022.06.017_bib22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(18)31814-2","article-title":"Fixed-dose combinations for hypertension","volume":"392","author":"Kishore","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2022.06.017_bib23","article-title":"Effect of FIXed-dose combination of ARb and statin on adherence and risk factor control: the randomized FIXAR study","author":"Chung","year":"2020","journal-title":"Cardiol J"},{"issue":"7","key":"10.1016\/j.numecd.2022.06.017_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011581","article-title":"Association of lowering low-density lipoprotein cholesterol with contemporary lipid-lowering therapies and risk of diabetes mellitus: a systematic review and meta-analysis","volume":"8","author":"Khan","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.numecd.2022.06.017_bib25","article-title":"Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"issue":"10313","key":"10.1016\/j.numecd.2022.06.017_bib26","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(21)01920-6","article-title":"Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis","volume":"398","author":"Nazarzadeh","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.numecd.2022.06.017_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2011.06.028","article-title":"ESC\/EAS guidelines for the management of dyslipidaemias the task force for the management of dyslipidaemias of the European society of cardiology (ESC) and the European atherosclerosis society (EAS)","volume":"217","author":"Catapano","year":"2011","journal-title":"Atherosclerosis"},{"issue":"18","key":"10.1016\/j.numecd.2022.06.017_bib28","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1177\/2047487316667784","volume":"23","author":"Kotseva","year":"2016","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2022.06.017_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijcard.2018.06.104","article-title":"Cost-effectiveness of optimized adherence to prevention guidelines in European patients with coronary heart disease: Results from the EUROASPIRE IV survey","volume":"272","author":"De Smedt","year":"2018","journal-title":"Int J Cardiol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475322002824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475322002824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:23:21Z","timestamp":1760545401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475322002824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0939475322002824"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2022.06.017","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2022.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}