{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:41:05Z","timestamp":1775176865660,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.numecd.2022.09.003","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T12:02:29Z","timestamp":1663243349000},"page":"2883-2889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between de novo lipogenesis susceptibility genes and coronary artery disease"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-8330","authenticated-orcid":false,"given":"Pomme I.H.G.","family":"Simons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Valkenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen D.A.","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn C.G.J.","family":"Brouwers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2022.09.003_bib1","doi-asserted-by":"crossref","first-page":"154170","DOI":"10.1016\/j.metabol.2020.154170","article-title":"Complications, morbidity and mortality of nonalcoholic fatty liver disease","volume":"111","author":"Mantovani","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.numecd.2022.09.003_bib2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2008.06.018","article-title":"Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease","volume":"49","author":"Ong","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2022.09.003_bib3","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.numecd.2022.09.003_bib4","first-page":"100056","article-title":"Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease","volume":"3","author":"Miao","year":"2021","journal-title":"HGG Adv"},{"key":"10.1016\/j.numecd.2022.09.003_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00125-019-05024-3","article-title":"Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality","volume":"63","author":"Brouwers","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2022.09.003_bib6","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/hep4.1319","article-title":"Relationship between nonalcoholic fatty liver disease susceptibility genes and coronary artery disease","volume":"3","author":"Brouwers","year":"2019","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.numecd.2022.09.003_bib8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2022.09.003_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1262-3636(07)70061-7","article-title":"Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease","volume":"29","author":"Diraison","year":"2003","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.numecd.2022.09.003_bib10","first-page":"3979","article-title":"Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene","volume":"117","author":"Selva","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2022.09.003_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.tem.2021.05.002","article-title":"Sex hormone-binding globulin: biomarker and hepatokine?","volume":"32","author":"Simons","year":"2021","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2022.09.003_bib12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cen.14459","article-title":"Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans","volume":"95","author":"Simons","year":"2021","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.numecd.2022.09.003_bib13","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","article-title":"Using human genetics to understand the disease impacts of testosterone in men and women","volume":"26","author":"Ruth","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.numecd.2022.09.003_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1161\/CIRCGENETICS.112.964619","article-title":"Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium","volume":"6","author":"Wu","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib16","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/ng.3913","article-title":"Association analyses based on false discovery rate implicate new loci for coronary artery disease","volume":"49","author":"Nelson","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jrsm.11","article-title":"Outlier and influence diagnostics for meta-analysis","volume":"1","author":"Viechtbauer","year":"2010","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.numecd.2022.09.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Software"},{"key":"10.1016\/j.numecd.2022.09.003_bib19","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jhep.2012.07.030","article-title":"Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in\u00a0vitro","volume":"57","author":"Pirazzi","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2022.09.003_bib20","doi-asserted-by":"crossref","first-page":"E821","DOI":"10.1210\/jc.2014-4464","article-title":"Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant","volume":"100","author":"Mancina","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.numecd.2022.09.003_bib21","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.119.041998","article-title":"Association between triglyceride lowering and reduction of cardiovascular risk across multiple lipid-lowering therapeutic classes","volume":"140","author":"Marston","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2022.09.003_bib22","first-page":"e002711","article-title":"Genetic determinants of lipids and cardiovascular disease outcomes","volume":"12","author":"Allara","year":"2019","journal-title":"Circulation: Genomic and Precision Medicine"},{"key":"10.1016\/j.numecd.2022.09.003_bib23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ng.2795","article-title":"Common variants associated with plasma triglycerides and risk for coronary artery disease","volume":"45","author":"Do","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib24","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease","volume":"130","author":"Smith","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2022.09.003_bib25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng2048","article-title":"Variation in FTO contributes to childhood obesity and severe adult obesity","volume":"39","author":"Dina","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib26","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/ncomms2537","article-title":"De novo lipogenesis in human fat and liver is linked to ChREBP-\u03b2 and metabolic health","volume":"4","author":"Eissing","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.numecd.2022.09.003_bib27","doi-asserted-by":"crossref","first-page":"E1125","DOI":"10.1210\/jc.2015-1587","article-title":"Hepatic de novo lipogenesis in obese youth is modulated by a common variant in the GCKR gene","volume":"100","author":"Santoro","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.numecd.2022.09.003_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10409231003667500","article-title":"Genetic control of de novo lipogenesis: role in diet-induced obesity","volume":"45","author":"Strable","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.numecd.2022.09.003_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.nutr.17.1.77","article-title":"Regulation of mammalian acetyl-coenzyme a carboxylase","volume":"17","author":"Kim","year":"1997","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.numecd.2022.09.003_bib30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/oxfordjournals.aje.a117662","article-title":"Serum fatty acids and the risk of coronary heart disease","volume":"142","author":"Simon","year":"1995","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2022.09.003_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0939-4753(03)80029-7","article-title":"Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"13","author":"Wang","year":"2003","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2022.09.003_bib32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3945\/ajcn.111.012054","article-title":"Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study","volume":"94","author":"Wu","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2022.09.003_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/ajcn\/nqy304","article-title":"Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers","volume":"109","author":"Rosqvist","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2022.09.003_bib34","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1093\/hmg\/ddp357","article-title":"The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver","volume":"18","author":"Beer","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00125-011-2348-5","article-title":"Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk","volume":"55","author":"Rees","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2022.09.003_bib36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.molmed.2015.08.004","article-title":"Modulation of glucokinase regulatory protein: a double-edged sword?","volume":"21","author":"Brouwers","year":"2015","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.numecd.2022.09.003_bib37","doi-asserted-by":"crossref","first-page":"e0206174","DOI":"10.1371\/journal.pone.0206174","article-title":"Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: a systematic review and meta-analysis","volume":"13","author":"Simons","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2022.09.003_bib38","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.numecd.2022.09.003_bib39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature12724","article-title":"Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors","volume":"504","author":"Lloyd","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2022.09.003_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S2213-8587(18)30105-0","article-title":"Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study","volume":"6","author":"Zhu","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.numecd.2022.09.003_bib41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S2213-8587(18)30196-7","article-title":"Non-alcoholic fatty liver disease concerns with glucokinase activators","volume":"6","author":"Hodson","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.numecd.2022.09.003_bib42","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","article-title":"Evaluating the potential role of pleiotropy in Mendelian randomization studies","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.numecd.2022.09.003_bib43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475322003726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475322003726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:22:10Z","timestamp":1760545330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475322003726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0939475322003726"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2022.09.003","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between de novo lipogenesis susceptibility genes and coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2022.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}]}}