{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:54:50Z","timestamp":1760576090838,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.numecd.2023.01.018","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T17:23:04Z","timestamp":1675012984000},"page":"883-891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Individual or familial diabetes in relation to eight cardiovascular diseases: A two-sample Mendelian randomization study"],"prefix":"10.1016","volume":"33","author":[{"given":"Meng-Jin","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Shan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2023.01.018_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas, 9(th) edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.numecd.2023.01.018_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ypmed.2016.12.015","article-title":"Association between family history of diabetes and cardiovascular disease and lifestyle risk factors in the United States population: the 2009-2012 National Health and Nutrition Examination Survey","volume":"96","author":"Akhuemonkhan","year":"2017","journal-title":"Prev Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib3","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/aje\/kwq266","article-title":"Glucose, insulin, and incident hypertension in the multi-ethnic study of atherosclerosis","volume":"172","author":"Levin","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2023.01.018_bib4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2337\/diacare.26.3.805","article-title":"Insulin sensitivity and the risk of incident hypertension: insights from the Insulin Resistance Atherosclerosis Study","volume":"26","author":"Goff","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2023.01.018_bib5","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","article-title":"Effects of intensive glucose lowering in type 2 diabetes","volume":"358","author":"Gerstein","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib6","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib7","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa1307684","article-title":"Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus","volume":"369","author":"Scirica","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib8","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.2337\/diabetes.49.12.2201","article-title":"Parental transmission of type 2 diabetes: the framingham offspring study","volume":"49","author":"Meigs","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2023.01.018_bib9","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/01.STR.0000158920.67013.53","article-title":"Family history of stroke in patients with transient ischemic attack in relation to hypertension and other intermediate phenotypes","volume":"36","author":"Flossmann","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.numecd.2023.01.018_bib10","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1001\/jama.291.18.2204","article-title":"Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring","volume":"291","author":"Lloyd-Jones","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2023.01.018_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.publhealth.012809.103621","article-title":"Family history in public health practice: a genomic tool for disease prevention and health promotion","volume":"31","author":"Valdez","year":"2010","journal-title":"Annu Rev Publ Health"},{"key":"10.1016\/j.numecd.2023.01.018_bib12","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2023.01.018_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib14","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2023.01.018_bib15","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.numecd.2023.01.018_bib16","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","article-title":"Evaluating the potential role of pleiotropy in Mendelian randomization studies","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.numecd.2023.01.018_bib17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2023.01.018_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/EDE.0000000000000559","article-title":"Sensitivity analyses for robust causal inference from mendelian randomization analyses with multiple genetic variants","volume":"28","author":"Burgess","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.numecd.2023.01.018_bib19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"year":"2019","series-title":"MRC IEU UK Biobank GWAS pipeline version 2","author":"Mitchell","key":"10.1016\/j.numecd.2023.01.018_bib20a"},{"key":"10.1016\/j.numecd.2023.01.018_bib20b","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003410","article-title":"Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: a multivariable Mendelian randomization study","volume":"17","author":"Rosoff","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/CIRCRESAHA.118.314487","article-title":"Type 2 diabetes and hypertension","volume":"124","author":"Sun","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.numecd.2023.01.018_bib22","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/eurheartj\/ehv083","article-title":"Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease","volume":"36","author":"Ross","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2023.01.018_bib23","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1007\/s00125-021-05436-0","article-title":"Impact of high glucose levels and glucose lowering on risk of ischaemic stroke: a Mendelian randomisation study and meta-analysis","volume":"64","author":"Benn","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2023.01.018_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2023.01.018_bib25","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00125-012-2715-x","article-title":"The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study","volume":"56","author":"Scott","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2023.01.018_bib27","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/joim.12289","article-title":"Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?","volume":"277","author":"Cederberg","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.numecd.2023.01.018_bib28","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1007\/s00125-016-3988-2","article-title":"Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children","volume":"59","author":"Berentzen","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2023.01.018_bib29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/clc.20355","article-title":"Prevalence of emerging cardiovascular risk factors in younger individuals with a family history of premature coronary heart disease and low Framingham risk score","volume":"31","author":"Sailam","year":"2008","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.numecd.2023.01.018_bib30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.diabres.2011.12.017","article-title":"Health beliefs among individuals at increased familial risk for type 2 diabetes: implications for prevention","volume":"96","author":"Dorman","year":"2012","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475323000315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475323000315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:25:25Z","timestamp":1760545525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475323000315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0939475323000315"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2023.01.018","relation":{},"ISSN":["0939-4753"],"issn-type":[{"type":"print","value":"0939-4753"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individual or familial diabetes in relation to eight cardiovascular diseases: A two-sample Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2023.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}]}}