{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:30:51Z","timestamp":1790800251063,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.numecd.2023.04.015","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T20:07:41Z","timestamp":1682194061000},"page":"1437-1443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Associations between systemic immune-inflammation index and abdominal aortic calcification: Results of a nationwide survey"],"prefix":"10.1016","volume":"33","author":[{"given":"Ruijie","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-0785","authenticated-orcid":false,"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2023.04.015_bib1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fcvm.2018.00174","article-title":"Cell-matrix interactions and matricrine signaling in the pathogenesis of vascular calcification","volume":"5","author":"Ngai","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.numecd.2023.04.015_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bone.2015.12.004","article-title":"Abdominal aortic calcification: a reappraisal of epidemiological and pathophysiological data","volume":"84","author":"Szulc","year":"2016","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.numecd.2023.04.015_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(97)00106-8","article-title":"New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study","volume":"132","author":"Kauppila","year":"1997","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.numecd.2023.04.015_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216415","article-title":"Malnutrition, inflammation, progression of vascular calcification and survival: inter-relationships in hemodialysis patients","volume":"14","author":"Choi","year":"2019","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.numecd.2023.04.015_bib5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/heartjnl-2011-301464","article-title":"Calcification of the abdominal aorta as an independent predictor of cardiovascular events: a meta-analysis","volume":"98","author":"Bastos Gon\u00e7alves","year":"2012","journal-title":"Heart"},{"issue":"3","key":"10.1016\/j.numecd.2023.04.015_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1359\/jbmr.091005","article-title":"Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarction","volume":"25","author":"Bolland","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.numecd.2023.04.015_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11657-021-00927-4","article-title":"Osteoporosis was associated with severe abdominal aortic calcification based on a cross-sectional study","volume":"16","author":"Wu","year":"2021","journal-title":"Arch Osteoporosis"},{"key":"10.1016\/j.numecd.2023.04.015_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.922903","article-title":"Saturation effect of body mass index on bone mineral density in adolescents of different ages: a population-based study","volume":"13","author":"Ouyang","year":"2022","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.numecd.2023.04.015_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.10.021","article-title":"Vascular calcification: mechanisms of vascular smooth muscle cell calcification","volume":"25","author":"Leopold","year":"2015","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.numecd.2023.04.015_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.870169","article-title":"Higher blood cadmium concentration is associated with increased likelihood of abdominal aortic calcification","volume":"9","author":"Qin","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"23","key":"10.1016\/j.numecd.2023.04.015_bib11","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.numecd.2023.04.015_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/CIA.S285000","article-title":"Association between systemic immune-inflammation index and diabetic depression","volume":"16","author":"Wang","year":"2021","journal-title":"Clin Interv Aging"},{"issue":"12","key":"10.1016\/j.numecd.2023.04.015_bib13","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/cam4.4606","article-title":"Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population","volume":"11","author":"Tian","year":"2022","journal-title":"Cancer Med"},{"key":"10.1016\/j.numecd.2023.04.015_bib14","article-title":"Preoperative systemic immune-inflammation index (SII) as a superior predictor of long-term survival outcome in patients with stage I-II gastric cancer after radical surgery","volume":"12","author":"He","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.numecd.2023.04.015_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1071465","article-title":"Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: evidence from NHANES 2011-2018","volume":"13","author":"Guo","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.numecd.2023.04.015_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.925690","article-title":"Association between SII and hepatic steatosis and liver fibrosis: a population-based study","volume":"13","author":"Xie","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.numecd.2023.04.015_bib17","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/echo.15343","article-title":"Atherosclerotic burden and systemic immune inflammation index","volume":"39","author":"Yavuz","year":"2022","journal-title":"Echocardiogr."},{"key":"10.1016\/j.numecd.2023.04.015_bib18","article-title":"Value of the systemic immune-inflammatory index (SII) in predicting the prognosis of patients with peripartum cardiomyopathy","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/j.numecd.2023.04.015_bib19","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s40520-022-02103-1","article-title":"Evaluating the systemic immune-inflammation index for in-hospital and long-term mortality in elderly non-ST-elevation myocardial infarction patients","volume":"34","author":"Orhan","year":"2022","journal-title":"Aging Clin Exp Res"},{"issue":"23","key":"10.1016\/j.numecd.2023.04.015_bib20","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1007\/s00018-021-03979-4","article-title":"MicroRNA-34a: the bad guy in age-related vascular diseases","volume":"78","author":"Raucci","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10.1016\/j.numecd.2023.04.015_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24473","article-title":"A U-shaped association between serum albumin with total triiodothyronine in adults","volume":"36","author":"Zhang","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.numecd.2023.04.015_bib22","article-title":"Is assessing the degree of hepatic steatosis and fibrosis based on index calculations the best choice for epidemiological studies?","volume":"317","author":"Xie","year":"2022","journal-title":"Environ Pollut"},{"key":"10.1016\/j.numecd.2023.04.015_bib23","article-title":"Association between 19 dietary fatty acids intake and rheumatoid arthritis: results of a nationwide survey","author":"Xie","year":"2022","journal-title":"Prostagl Leukot Essent Fat Acids"},{"key":"10.1016\/j.numecd.2023.04.015_bib24","first-page":"3521","article-title":"Race and gender differences in the associations between cadmium exposure and bone mineral density in US adults","author":"Xie","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.numecd.2023.04.015_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.975400","article-title":"Systemic immune-inflammation index and bone mineral density in postmenopausal women: a cross-sectional study of the national health and nutrition examination survey (NHANES) 2007-2018","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.numecd.2023.04.015_bib26","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.numecd.2021.04.010","article-title":"Association between the triglyceride-glucose index and abdominal aortic calcification in adults: a cross-sectional study","volume":"31","author":"Chen","year":"2021","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2023.04.015_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.126975","article-title":"Relationship between blood cadmium and abdominal aortic calcification: NHANES 2013-2014","volume":"72","author":"Liu","year":"2022","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"10.1016\/j.numecd.2023.04.015_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-24756-8","article-title":"The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged \u2265 40 years: results from NHANES 2013-2014","volume":"12","author":"Qin","year":"2022","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.numecd.2023.04.015_bib29","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.tjnut.2022.10.015","article-title":"Index-based calculation or Transient Elastography to assess the degree of hepatic steatosis and fibrosis","volume":"153","author":"Xie","year":"2023","journal-title":"J Nutr"},{"issue":"41","key":"10.1016\/j.numecd.2023.04.015_bib30","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031164","article-title":"Relationship between nonalcoholic fatty liver disease and bone mineral density in adolescents","volume":"101","author":"Xie","year":"2022","journal-title":"Medicine (Baltim)"},{"issue":"4","key":"10.1016\/j.numecd.2023.04.015_bib31","doi-asserted-by":"crossref","first-page":"F663","DOI":"10.1152\/ajprenal.00189.2016","article-title":"MICS, an easily ignored contributor to arterial calcification in CKD patients","volume":"311","author":"Zhang","year":"2016","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.numecd.2023.04.015_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000479254","article-title":"End-stage renal disease, inflammation and cardiovascular outcomes","volume":"191","author":"Dai","year":"2017","journal-title":"Contrib Nephrol"},{"issue":"3","key":"10.1016\/j.numecd.2023.04.015_bib33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.numecd.2013.08.006","article-title":"Osteoprotegerin, inflammation and dyslipidemia are associated with abdominal aortic calcification in non-diabetic patients on peritoneal dialysis","volume":"24","author":"Huang","year":"2014","journal-title":"Nutr Metabol Cardiovasc Dis"},{"issue":"1","key":"10.1016\/j.numecd.2023.04.015_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13018-022-02986-w","article-title":"Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018","volume":"17","author":"Xie","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.numecd.2023.04.015_bib35","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2147\/IJGM.S353531","article-title":"High low-density lipoprotein cholesterol levels are associated with osteoporosis among adults 20-59 Years of age","volume":"15","author":"Xie","year":"2022","journal-title":"Int J Gen Med"},{"issue":"4","key":"10.1016\/j.numecd.2023.04.015_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5217\/ir.2022.00017","article-title":"Abdominal aortic calcification in patients with inflammatory bowel disease: does anti-tumor necrosis factor \u03b1 use protect from chronic inflammation-induced atherosclerosis?","volume":"20","author":"Mantaka","year":"2022","journal-title":"Intest Res"},{"key":"10.1016\/j.numecd.2023.04.015_bib37","article-title":"Greater dietary inflammatory potential is associated with higher likelihood of abdominal aortic calcification","volume":"8","author":"Qin","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"34","key":"10.1016\/j.numecd.2023.04.015_bib38","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.3748\/wjg.v23.i34.6261","article-title":"Systemic immune-inflammation index for predicting prognosis of colorectal cancer","volume":"23","author":"Chen","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.numecd.2023.04.015_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.933913","article-title":"Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: a systematic review and meta-analysis","volume":"9","author":"Ye","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.numecd.2023.04.015_bib40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.amjcard.2010.03.062","article-title":"Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction","volume":"106","author":"Azab","year":"2010","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.numecd.2023.04.015_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1590\/0004-282x20190001","article-title":"Inflammatory markers are beneficial in the early stages of cerebral venous thrombosis","volume":"77","author":"Tekesin","year":"2019","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.numecd.2023.04.015_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1101574","article-title":"Systemic-immune-inflammation index as a promising biomarker for predicting perioperative ischemic stroke in older patients who underwent non-cardiac surgery","volume":"14","author":"Zhang","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.numecd.2023.04.015_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2021.04.010","article-title":"IL-2R\u03b2\u03b3 signalling in lymphocytes promotes systemic inflammation and reduces plasma cholesterol in atherosclerotic mice","volume":"326","author":"Mulholland","year":"2021","journal-title":"Atherosclerosis"},{"issue":"22","key":"10.1016\/j.numecd.2023.04.015_bib44","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1111\/bph.13845","article-title":"Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges","volume":"174","author":"Kyaw","year":"2017","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.numecd.2023.04.015_bib45","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.ijcard.2013.01.211","article-title":"Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification","volume":"168","author":"Wen","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.numecd.2023.04.015_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bone.2019.04.006","article-title":"IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2","volume":"124","author":"Kurozumi","year":"2019","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.numecd.2023.04.015_bib47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/path.5193","article-title":"Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification\u00a0through downregulation of BMPR2","volume":"247","author":"S\u00e1nchez-Duffhues","year":"2019","journal-title":"J Pathol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532300162X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532300162X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:24:39Z","timestamp":1760545479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947532300162X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S093947532300162X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2023.04.015","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between systemic immune-inflammation index and abdominal aortic calcification: Results of a nationwide survey","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2023.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}