{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:44Z","timestamp":1791644444887,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.numecd.2023.10.009","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:07:24Z","timestamp":1697047644000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-term increase in serum uric acid and its predictors over a 25\u00a0year follow-up: Results of the PAMELA study"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-6264","authenticated-orcid":false,"given":"Alessandro","family":"Maloberti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Dell\u2019Oro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bombelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fosca","family":"Quarti-Trevano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-8073","authenticated-orcid":false,"given":"Rita","family":"Facchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-6547","authenticated-orcid":false,"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2023.10.009_bib1","first-page":"92","article-title":"Hyperuricaemia: relationships to body fat distribution, and other components of the insulin resistance syndrome on 38-yer old healthy men and women","volume":"19","author":"Cigolini","year":"1995","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.numecd.2023.10.009_bib2","first-page":"3076","article-title":"Positive association between body fat percentage and hyperuricemia in patients with hypertension: the China H-type hypertension registry study","author":"Xiong","year":"2012","journal-title":"Nutr Met Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2023.10.009_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1758-5996-4-3","article-title":"The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus","volume":"4","author":"Kim","year":"2012","journal-title":"Diabetol Metab Syndrome"},{"key":"10.1016\/j.numecd.2023.10.009_bib4","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/HJH.0000000000001721","article-title":"Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study","volume":"36","author":"Bombelli","year":"2018","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MD.0000000000017597","article-title":"Risk factors for the development of hyperuricemia. A STROBE-compliant cross sectional and longitudinal study","volume":"98","author":"Ni","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.numecd.2023.10.009_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/HYPERTENSIONAHA.119.13643","article-title":"Identification of the uric acid thresholds predicting an increased total and cardiovascular mortality over 20 years","volume":"75","author":"Virdis","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2023.10.009_bib7","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1016\/j.numecd.2022.09.004","article-title":"The associations between fasting glucose, lipids and uric acid levels strengthen with the decile of uric acid increase and differ by sex","volume":"32","author":"Wang","year":"2022","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2023.10.009_bib8","article-title":"Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study","volume":"13","author":"Li","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.numecd.2023.10.009_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10654-007-9132-3","article-title":"Ten-year change in serum uric acid and its relation to changes in other metabolic risk factors in young black and white adults: the CARDIA study","volume":"22","author":"Rathmann","year":"2007","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2023.10.009_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10067-007-0732-9","article-title":"Change in serum uric acid between baseline and 1-year follow-up and its associated factors in male subjects","volume":"27","author":"Choe","year":"2008","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.numecd.2023.10.009_bib11","doi-asserted-by":"crossref","unstructured":"Bombelli M, Facchetti R, Fodri D, Brambilla G, Sega R, Grassi G, et\u00a0al. Impact of body mass and waist circumference on the cardiovascular risk and all-cause death in a general population: data fron the PAMELA study. Nutr Met Cardiovasc Dis 201;23;650-656.","DOI":"10.1016\/j.numecd.2012.01.004"},{"key":"10.1016\/j.numecd.2023.10.009_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2023.10.009_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/HJH.0000000000002600","article-title":"Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study","volume":"39","author":"Maloberti","year":"2021","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib14","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1161\/01.STR.0000221716.55088.d4","article-title":"Uric acid is a risk factor for myocardial infarction and stroke","volume":"37","author":"Bos","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.numecd.2023.10.009_bib15","article-title":"Serum uric acid is associated with incident chronic kidney disease in middle-aged populations: a meta-analysis of 15 cohort studies","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2023.10.009_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12882-015-0207-1","article-title":"Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: the Troms\u00f8 Study","volume":"16","author":"Storhaug","year":"2015","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.numecd.2023.10.009_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/HJH.0000000000002589","article-title":"Serum uric acid predicts heart failure in a large Italian cohort: search for a cut-off value. The URic acid Right for heArt Health (URRAh) study","volume":"39","author":"Muiesan","year":"2021","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib18","first-page":"4136373","article-title":"The Association between baseline, changes in uric acid and renal failure in the elderly Chinese individuals: a Prospective Study with a 3-Year Follow-Up","author":"Lai","year":"2022","journal-title":"Internet J Endocrinol"},{"key":"10.1016\/j.numecd.2023.10.009_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejim.2023.04.010","article-title":"Serum uric acid and left ventricular mass independently predict cardiovascular mortality:the URic acid Right for heArt Health (URRAh) project","volume":"114","author":"Muiesan","year":"2023","journal-title":"Eur J Intern Med"},{"issue":"Suppl 4","key":"10.1016\/j.numecd.2023.10.009_bib20","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/00005344-200000004-00003","article-title":"Mechanisms and clinical implications of blood pressure variability","volume":"35","author":"Mancia","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.numecd.2023.10.009_bib21","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/00004872-199816110-00010","article-title":"Heart rate as marker of sympathetic activity","volume":"16","author":"Grassi","year":"1998","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jash.2016.02.015","article-title":"Evidence for a critical role of the sympathetic nervous system in hypertension","volume":"10","author":"Grassi","year":"2016","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib23","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/HJH.0000000000001212","article-title":"Serum uric acid and the relationship with subclinical organ damage in adults","volume":"35","author":"Lambert","year":"2017","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib24","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1093\/eurjpc\/zwab023","article-title":"High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid","volume":"29","author":"Palatini","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2023.10.009_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/HYPERTENSIONAHA.120.14804","article-title":"Association between the European Society of Cardiology\/European Society of Hypertension heart rate thresholds for cardiovascular risk and neuroadrenergic markers","volume":"76","author":"Grassi","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2023.10.009_bib26","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1097\/HJH.0000000000001814","article-title":"Uric acid is linked to cardiometabolic risk factors in overweight and obese youths","volume":"36","author":"Lurbe","year":"2018","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jch.14613","article-title":"Uric acid relationships with lipid profile and adiposity indices: impact of different hyperuricemic thresholds","volume":"25","author":"Maloberti","year":"2023","journal-title":"J Clin Hypertens"},{"key":"10.1016\/j.numecd.2023.10.009_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.numecd.2022.11.024","article-title":"Hyperuricemia increase the risk of cardiovascular mortality associated with very high HDL-cholesterol level","volume":"33","author":"Palatini","year":"2023","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2023.10.009_bib29","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","article-title":"Uric acid and oxidative stress","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr Pharmaceut Des"},{"key":"10.1016\/j.numecd.2023.10.009_bib30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41440-018-0095-4","article-title":"Effects of uric acid on vascular endothelial function from bedside to bench","volume":"41","author":"Otani","year":"2018","journal-title":"Hypertens Res"},{"key":"10.1016\/j.numecd.2023.10.009_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/abbi.1996.9844","article-title":"Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes","volume":"339","author":"Radi","year":"1997","journal-title":"Arch Biochem Biophys"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532300412X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532300412X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:27:35Z","timestamp":1760545655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947532300412X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S093947532300412X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2023.10.009","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term increase in serum uric acid and its predictors over a 25\u00a0year follow-up: Results of the PAMELA study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2023.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}]}}