{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:57:10Z","timestamp":1790204230774,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11200391"],"award-info":[{"award-number":["11200391"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1201635"],"award-info":[{"award-number":["1201635"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.numecd.2024.03.001","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T21:59:23Z","timestamp":1709589563000},"page":"1681-1691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-3687","authenticated-orcid":false,"given":"Javier","family":"Enr\u00edquez-Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Mautner Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Kalazich Rosales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Ruiz-Uribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Fuentes Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Monrroy Uarac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"C\u00e1rcamo Ibaceta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-2903","authenticated-orcid":false,"given":"Daniel J.","family":"Fazakerley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Larance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-7570","authenticated-orcid":false,"given":"Pamela","family":"Ehrenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-5571","authenticated-orcid":false,"given":"Sergio","family":"Mart\u00ednez-Huenchull\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2024.03.001_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/oby.23444","article-title":"Metabolic dysfunction and obesity-related cancer: beyond obesity and metabolic syndrome","volume":"30","author":"Karra","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.numecd.2024.03.001_bib2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.soard.2022.08.013","article-title":"American society for metabolic and bariatric surgery (ASMBS) and international federation for the surgery of obesity and metabolic disorders (IFSO): indications for metabolic and bariatric surgery","volume":"18","author":"Eisenberg","year":"2022","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.numecd.2024.03.001_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197248","article-title":"Predictive score of sarcopenia occurrence one year after bariatric surgery in severely obese patients","volume":"13","author":"Voican","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2024.03.001_bib4","first-page":"583","article-title":"The risk of sarcopenia 24 months after bariatric surgery - assessment by dual energy X-ray absorptiometry (DEXA): a prospective study","volume":"15","author":"Pekar","year":"2020","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"10.1016\/j.numecd.2024.03.001_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1378\/chest.130.2.517","article-title":"Cardiorespiratory fitness and short-term complications after bariatric surgery","volume":"130","author":"McCullough","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.numecd.2024.03.001_bib6","first-page":"1468","article-title":"Exercise and physical activity in adults who underwent bariatric surgery. Consensus document","volume":"147","author":"Cancino-Ramirez","year":"2019","journal-title":"Rev Med Chile"},{"key":"10.1016\/j.numecd.2024.03.001_bib7","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/oby.2010.88","article-title":"Pre- to postoperative physical activity changes in bariatric surgery patients: self report vs. objective measures","volume":"18","author":"Bond","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.numecd.2024.03.001_bib8","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1007\/s11695-018-3434-2","article-title":"A cross-sectional study of reported exercise and medium-term weight loss following laparoscopic bariatric surgery","volume":"28","author":"Kerrigan","year":"2018","journal-title":"Obes Surg"},{"key":"10.1016\/j.numecd.2024.03.001_bib9","article-title":"Effects of a combined high-intensity interval training and resistance training program in patients awaiting bariatric surgery: a pilot study","volume":"7","author":"Pico-Sirvent","year":"2019","journal-title":"Sports (Basel)"},{"key":"10.1016\/j.numecd.2024.03.001_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166299","article-title":"High-intensity interval training elicits higher enjoyment than moderate intensity continuous exercise","volume":"12","author":"Thum","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2024.03.001_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.resp.2019.05.009","article-title":"High- or moderate-intensity training promotes change in cardiorespiratory fitness, but not visceral fat, in obese men: a randomised trial of equal energy expenditure exercise","volume":"266","author":"Gerosa-Neto","year":"2019","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.numecd.2024.03.001_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210644","article-title":"Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and\/or obesity: a meta-analysis","volume":"14","author":"Su","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2024.03.001_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/834865","article-title":"Continuous exercise but not high intensity interval training improves fat distribution in overweight adults","volume":"2014","author":"Keating","year":"2014","journal-title":"J Obes"},{"key":"10.1016\/j.numecd.2024.03.001_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fphys.2019.00459","article-title":"Constant-moderate and high-intensity interval training have differential benefits on insulin sensitive tissues in high-fat fed mice","volume":"10","author":"Martinez-Huenchullan","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.numecd.2024.03.001_bib15","article-title":"Differential metabolic effects of constant moderate versus high intensity interval training in high-fat fed mice: possible role of muscle adiponectin","volume":"6","author":"Martinez-Huenchullan","year":"2018","journal-title":"Phys Rep"},{"key":"10.1016\/j.numecd.2024.03.001_bib16","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.numecd.2024.03.001_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.tem.2021.08.008","article-title":"Stress-induced FGF21 and GDF15 in obesity and obesity resistance","volume":"32","author":"Keipert","year":"2021","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2024.03.001_bib18","article-title":"Association of serum adipsin level with insulin resistance and inflammatory markers in newly diagnosed type two diabetes mellitus patients","author":"Singh","year":"2023","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.numecd.2024.03.001_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/13813455.2019.1662450","article-title":"The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome","volume":"128","author":"Aktas","year":"2022","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.numecd.2024.03.001_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1037948","article-title":"GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans","volume":"13","author":"Plomgaard","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.numecd.2024.03.001_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/08977194.2023.2279163","article-title":"The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus","volume":"42","author":"Riahy","year":"2024","journal-title":"Growth Factors"},{"key":"10.1016\/j.numecd.2024.03.001_bib22","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.TIR120.002343","article-title":"Blockade of high-fat diet proteomic phenotypes using exercise as prevention or treatment","volume":"20","author":"Martinez-Huenchullan","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.numecd.2024.03.001_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/obr.12317","article-title":"The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis","volume":"16","author":"Jelleyman","year":"2015","journal-title":"Obes Rev"},{"key":"10.1016\/j.numecd.2024.03.001_bib24","first-page":"1","article-title":"Body composition assessment: a comparison of the DXA, InBody 270, and omron","volume":"3","author":"Czartoryski","year":"2020","journal-title":"J Exerc Nutr"},{"key":"10.1016\/j.numecd.2024.03.001_bib25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11695-010-0261-5","article-title":"Cardiorespiratory fitness and health-related quality of life in bariatric surgery patients","volume":"21","author":"Kolotkin","year":"2011","journal-title":"Obes Surg"},{"key":"10.1016\/j.numecd.2024.03.001_bib26","first-page":"72","article-title":"Peak oxygen uptake prediction in overweight and obese adults","volume":"34","author":"Castro","year":"2017","journal-title":"Arch Med Deporte"},{"key":"10.1016\/j.numecd.2024.03.001_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7120503","article-title":"Effects of exercise on the resting heart rate: a systematic review and meta-analysis of interventional studies","volume":"7","author":"Reimers","year":"2018","journal-title":"J Clin Med"},{"key":"10.1016\/j.numecd.2024.03.001_bib28","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1152\/ajpendo.00109.2021","article-title":"Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men","volume":"321","author":"Vion","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.numecd.2024.03.001_bib29","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3389\/fphys.2019.01274","article-title":"3-Weeks of exercise training increases ischemic-tolerance in hearts from high-fat diet fed mice","volume":"10","author":"Boardman","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.numecd.2024.03.001_bib30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.7570\/jomes.2019.28.4.278","article-title":"Effects of exercise on the body composition and lipid profile of individuals with obesity: a systematic review and meta-analysis","volume":"28","author":"Kim","year":"2019","journal-title":"J Obes Metab Syndr"},{"key":"10.1016\/j.numecd.2024.03.001_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.rehab.2021.101586","article-title":"Effect of high-intensity interval training protocols on VO(2)max and HbA1c level in people with type 2 diabetes: a systematic review and meta-analysis","volume":"65","author":"de Mello","year":"2022","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.numecd.2024.03.001_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.985404","article-title":"The effects of three different low-volume aerobic training protocols on cardiometabolic parameters of type 2 diabetes patients: a randomized clinical trial","volume":"14","author":"Gentil","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.numecd.2024.03.001_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.872624","article-title":"Chronic elevation of skeletal muscle [Ca(2+)](i) impairs glucose uptake. An in\u00a0vivo and in\u00a0vitro study","volume":"13","author":"Uryash","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.numecd.2024.03.001_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.901164","article-title":"The effect of regular aerobic exercise on renal function in patients with CKD: a systematic review and meta-analysis","volume":"13","author":"Ma","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.numecd.2024.03.001_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121740","article-title":"High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice","volume":"324","author":"Zheng","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.numecd.2024.03.001_bib36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/oby.21070","article-title":"Subclinical kidney injury before and 1 year after bariatric surgery among adolescents with severe obesity","volume":"23","author":"Xiao","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.numecd.2024.03.001_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14071430","article-title":"Adiponectin system (rescue hormone): the missing link between metabolic and cardiovascular diseases","volume":"14","author":"Aljafary","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.numecd.2024.03.001_bib38","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/oby.23503","article-title":"Measuring and estimating insulin resistance in clinical and research settings","volume":"30","author":"Gastaldelli","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.numecd.2024.03.001_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2021.11.002","article-title":"Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia","volume":"64","author":"Siddiqui","year":"2022","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.numecd.2024.03.001_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2014.06.005","article-title":"Adipsin is an adipokine that improves beta cell function in diabetes","volume":"158","author":"Lo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.numecd.2024.03.001_bib41","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2024.03.001_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1210\/jc.2010-1398","article-title":"Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males","volume":"96","author":"Anderwald","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.numecd.2024.03.001_bib43","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12265-020-10057-w","article-title":"Modulation of insulin sensitivity by exercise training: implications for cardiovascular prevention","volume":"14","author":"Iaccarino","year":"2021","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.numecd.2024.03.001_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.154008","article-title":"Skeletal muscle adiponectin induction in obesity and exercise","volume":"102","author":"Martinez-Huenchullan","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.numecd.2024.03.001_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/ijpvm.IJPVM_248_19","article-title":"The effect of all extremity high intensity interval training on athero-protective factors and endothelial function in overweight and obese women","volume":"12","author":"Hovsepian","year":"2021","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.numecd.2024.03.001_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111619","article-title":"Noradrenaline and ATP regulate adiponectin exocytosis in white adipocytes: disturbed adrenergic and purinergic signalling in obese and insulin-resistant mice","volume":"549","author":"Musovic","year":"2022","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.numecd.2024.03.001_bib47","first-page":"2020","article-title":"Gender disparities in weight loss surgery","author":"Aly","year":"2020","journal-title":"Mini-invasive Surgery"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324000875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324000875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:09:27Z","timestamp":1778558967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475324000875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0939475324000875"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2024.03.001","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2024.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}