{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:01:20Z","timestamp":1769097680520,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.numecd.2024.07.007","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:02:36Z","timestamp":1721088156000},"page":"2705-2712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inverse association between lung function and nonalcoholic fatty liver disease: An observational and mendelian randomization study"],"prefix":"10.1016","volume":"34","author":[{"given":"Chun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziliang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-7982","authenticated-orcid":false,"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.numecd.2024.07.007_bib1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.numecd.2024.07.007_bib2","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.numecd.2024.07.007_bib3","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1136\/gutjnl-2020-320622","article-title":"NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications","volume":"69","author":"Targher","year":"2020","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.numecd.2024.07.007_bib4","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jhep.2019.08.018","article-title":"The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity - a longitudinal cohort study","volume":"71","author":"Allen","year":"2019","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.numecd.2024.07.007_bib5","doi-asserted-by":"crossref","first-page":"E710","DOI":"10.1152\/ajpendo.00052.2019","article-title":"Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2\u03b1\/PPAR\u03b1 pathway","volume":"317","author":"Chen","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.numecd.2024.07.007_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/JOE-19-0555","article-title":"Oxygen therapy alleviates hepatic steatosis by inhibiting hypoxia-inducible factor-2\u03b1","volume":"246","author":"Yu","year":"2020","journal-title":"J Endocrinol"},{"key":"10.1016\/j.numecd.2024.07.007_bib7","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2147\/COPD.S166902","article-title":"Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: korea National Health and Nutrition Examination Survey, 2007-2010","volume":"13","author":"Moon","year":"2018","journal-title":"Int J Chronic Obstr Pulm Dis"},{"issue":"1","key":"10.1016\/j.numecd.2024.07.007_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12902-017-0168-4","article-title":"Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese","volume":"17","author":"Qin","year":"2017","journal-title":"BMC Endocr Disord"},{"issue":"21","key":"10.1016\/j.numecd.2024.07.007_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000907","article-title":"Association between pulmonary function and nonalcoholic fatty liver disease in the NHANES III study","volume":"94","author":"Peng","year":"2015","journal-title":"Medicine (Baltim)"},{"issue":"1","key":"10.1016\/j.numecd.2024.07.007_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208736","article-title":"Decreased lung function is associated with risk of developing non-alcoholic fatty liver disease: a longitudinal cohort study","volume":"14","author":"Song","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.numecd.2024.07.007_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12931-021-01768-y","article-title":"Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank","volume":"22","author":"Horsfall","year":"2021","journal-title":"Respir Res"},{"issue":"3","key":"10.1016\/j.numecd.2024.07.007_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"2","key":"10.1016\/j.numecd.2024.07.007_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S2213-2600(21)00369-6","article-title":"Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK Biobank cohort analysis","volume":"10","author":"Higbee","year":"2022","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.numecd.2024.07.007_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41588-018-0321-7","article-title":"New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries","volume":"51","author":"Shrine","year":"2019","journal-title":"Nat Genet"},{"issue":"24","key":"10.1016\/j.numecd.2024.07.007_bib15","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMoa1605086","article-title":"Genetic risk, adherence to a healthy lifestyle, and coronary disease","volume":"375","author":"Khera","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.numecd.2024.07.007_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172921","article-title":"Characterisation of liver fat in the UK Biobank cohort","volume":"12","author":"Wilman","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.numecd.2024.07.007_bib17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.31726","article-title":"Administrative coding in electronic health care record-based research of NAFLD: an expert panel consensus statement","volume":"74","author":"Hagstr\u00f6m","year":"2021","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.numecd.2024.07.007_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162388","article-title":"Algorithms for the capture and adjudication of prevalent and incident diabetes in UK biobank","volume":"11","author":"Eastwood","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2024.07.007_bib19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/alz.12320","article-title":"Midlife vascular risk factors and risk of incident dementia: longitudinal cohort and Mendelian randomization analyses in the UK Biobank","volume":"17","author":"Malik","year":"2021","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.numecd.2024.07.007_bib20","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.numecd.2024.07.007_bib21","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1093\/aje\/kwr026","article-title":"Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses","volume":"173","author":"Palmer","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2024.07.007_bib22","article-title":"Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes","volume":"47","author":"de la Rosa","year":"2021","journal-title":"Mol Metabol"},{"issue":"2","key":"10.1016\/j.numecd.2024.07.007_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jcmgh.2021.03.011","article-title":"Hypoxia via ERK signaling inhibits hepatic PPAR\u03b1 to promote fatty liver","volume":"12","author":"Mooli","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"19","key":"10.1016\/j.numecd.2024.07.007_bib24","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1038\/sj.emboj.7601300","article-title":"Failure to prolyl hydroxylate hypoxia-inducible factor \u03b1 phenocopies VHL inactivation in\u00a0vivo","volume":"25","author":"Kim","year":"2006","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.numecd.2024.07.007_bib25","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1073\/pnas.98.4.1583","article-title":"Vascular tumors in livers with targeted inactivation of the von Hippel\u2013Lindau tumor suppressor","volume":"98","author":"Haase","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.numecd.2024.07.007_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/HYPERTENSIONAHA.111.00272","article-title":"Associations among lung function, arterial elasticity, and circulating endothelial and inflammation markers: the multiethnic study of atherosclerosis","volume":"61","author":"Duprez","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2024.07.007_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1146456","article-title":"Associations between the muscle quality index and adult lung functions from NHANES 2011-2012","volume":"11","author":"Weng","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.numecd.2024.07.007_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2023.107197","article-title":"The creatinine-to-cystatin C ratio (a surrogate marker of muscle mass) as a predictor of lung function decline in older adults: a nationwide longitudinal study in China","volume":"211","author":"Wang","year":"2023","journal-title":"Respir Med"},{"issue":"9","key":"10.1016\/j.numecd.2024.07.007_bib29","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.3390\/nu15092068","article-title":"Innate immune system in the pathogenesis of non-alcoholic fatty liver disease","volume":"15","author":"Ma","year":"2023","journal-title":"Nutrients"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324002692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324002692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T20:37:20Z","timestamp":1737319040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475324002692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0939475324002692"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2024.07.007","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inverse association between lung function and nonalcoholic fatty liver disease: An observational and mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2024.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}