{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:13:43Z","timestamp":1787498023292,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009156","name":"Nantong City Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.numecd.2024.08.020","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T13:10:09Z","timestamp":1725455409000},"page":"103727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic inflammation markers and the prevalence of hypertension in 8- to 17-year-old children and adolescents: A NHANES cross-sectional study"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-6891","authenticated-orcid":false,"given":"Weiyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5388-9793","authenticated-orcid":false,"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.numecd.2024.08.020_bib1","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1097\/HJH.0000000000001039","article-title":"2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents","volume":"34","author":"Lurbe","year":"2016","journal-title":"J Hypertens"},{"issue":"6","key":"10.1016\/j.numecd.2024.08.020_bib2","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/HYPERTENSIONAHA.118.12334","article-title":"Relation of blood pressure in childhood to self-reported hypertension in adulthood","volume":"73","author":"Urbina","year":"2019","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.numecd.2024.08.020_bib3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s12098-021-03686-9","article-title":"Prevalence of hypertension among children and adolescents in India: a systematic Review and meta-analysis","volume":"88","author":"Meena","year":"2021","journal-title":"Indian J Pediatr"},{"issue":"6","key":"10.1016\/j.numecd.2024.08.020_bib4","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jpeds.2015.07.055","article-title":"Factors affecting tracking of blood pressure from childhood to adulthood: the childhood determinants of adult health study","volume":"167","author":"Kelly","year":"2015","journal-title":"J Pediatr"},{"issue":"8","key":"10.1016\/j.numecd.2024.08.020_bib5","first-page":"486","article-title":"High blood pressure in children and adolescents","volume":"98","author":"Riley","year":"2018","journal-title":"Am Fam Physician"},{"issue":"6","key":"10.1016\/j.numecd.2024.08.020_bib6","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.3928\/19382359-20200513-01","article-title":"Hypertension in children and adolescents: a Review of recent guidelines","volume":"49","author":"Siddiqui","year":"2020","journal-title":"Pediatr Ann"},{"issue":"35","key":"10.1016\/j.numecd.2024.08.020_bib7","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1093\/eurheartj\/ehac328","article-title":"Hypertension in children and adolescents","volume":"43","author":"de Simone","year":"2022","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.numecd.2024.08.020_bib8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/CIRCRESAHA.121.318082","article-title":"Pathophysiology of hypertension: the mosaic theory and beyond","volume":"128","author":"Harrison","year":"2021","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.numecd.2024.08.020_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/HYPERTENSIONAHA.119.13642","article-title":"Effects of interleukin-1beta inhibition on blood pressure, incident hypertension, and residual inflammatory risk: a secondary analysis of CANTOS","volume":"75","author":"Rothman","year":"2020","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.numecd.2024.08.020_bib10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41440-019-0245-3","article-title":"Neutrophil to lymphocyte ratio as predictor for incident hypertension: a 9-year cohort study in Taiwan","volume":"42","author":"Jhuang","year":"2019","journal-title":"Hypertens Res"},{"issue":"2","key":"10.1016\/j.numecd.2024.08.020_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11239-014-1103-4","article-title":"Platelet-lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome","volume":"39","author":"Koseoglu","year":"2015","journal-title":"J Thromb Thrombolysis"},{"issue":"4","key":"10.1016\/j.numecd.2024.08.020_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/j.pbj.0000000000000220","article-title":"The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study","volume":"8","author":"Pinho","year":"2023","journal-title":"Porto Biomed J"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41390-022-02056-1","article-title":"Lymphocyte to monocyte ratio and blood pressure variability in childhood hypertension-a pilot study","volume":"93","author":"Musial","year":"2023","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.numecd.2024.08.020_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41440-023-01195-0","article-title":"Systemic inflammation markers and the prevalence of hypertension: a NHANES cross-sectional study","volume":"46","author":"Xu","year":"2023","journal-title":"Hypertens Res"},{"issue":"3","key":"10.1016\/j.numecd.2024.08.020_bib15","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-1904","article-title":"Clinical practice guideline for screening and management of high blood pressure in children and adolescents","volume":"140","author":"Flynn","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2024.08.020_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138446","article-title":"Relationship between low-level lead, cadmium and mercury exposures and blood pressure in children and adolescents aged 8-17 years: an exposure-response analysis of NHANES 2007-2016","volume":"726","author":"Yao","year":"2020","journal-title":"Sci Total Environ"},{"issue":"7244","key":"10.1016\/j.numecd.2024.08.020_bib17","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.numecd.2024.08.020_bib18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"11","key":"10.1016\/j.numecd.2024.08.020_bib19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/cvr\/cvy112","article-title":"Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide","volume":"114","author":"Loperena","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.numecd.2024.08.020_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cjca.2020.01.013","article-title":"Inflammation in hypertension","volume":"36","author":"Xiao","year":"2020","journal-title":"Can J Cardiol"},{"issue":"5","key":"10.1016\/j.numecd.2024.08.020_bib21","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00004872-200205000-00018","article-title":"White blood cell count as a risk factor for hypertension; a study of Japanese male office workers","volume":"20","author":"Nakanishi","year":"2002","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1755-7682-5-2","article-title":"Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population","volume":"5","author":"Imtiaz","year":"2012","journal-title":"Int Arch Med"},{"issue":"11","key":"10.1016\/j.numecd.2024.08.020_bib23","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/ajh\/hpv034","article-title":"Blood neutrophil to lymphocyte ratio as a predictor of hypertension","volume":"28","author":"Liu","year":"2015","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1016\/j.numecd.2024.08.020_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0019-5359.30347","article-title":"Study of leukocytic hydrolytic enzymes in patients with acute stage of coronary heart disease","volume":"61","author":"Patil","year":"2007","journal-title":"Indian J Med Sci"},{"issue":"9062","key":"10.1016\/j.numecd.2024.08.020_bib25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0140-6736(96)09424-X","article-title":"Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?","volume":"349","author":"Vallance","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2024.08.020_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4939-1441-8_5","article-title":"Nitric oxide availability as a marker of oxidative stress","volume":"1208","author":"Pierini","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"4","key":"10.1016\/j.numecd.2024.08.020_bib27","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/sj.bjp.0705557","article-title":"Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats","volume":"141","author":"Ghosh","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.numecd.2024.08.020_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.743075","article-title":"Elucidation of a causal relationship between platelet count and hypertension: a Bi-directional mendelian randomization study","volume":"8","author":"Chiu","year":"2021","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.numecd.2024.08.020_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40885-015-0036-3","article-title":"The platelet-to-lymphocyte ratio reflects the severity of obstructive sleep apnea syndrome and concurrent hypertension","volume":"22","author":"Song","year":"2015","journal-title":"Clin Hypertens"},{"issue":"2","key":"10.1016\/j.numecd.2024.08.020_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1161\/01.HYP.0000049761.98155.7B","article-title":"Hypertension, platelets, and the endothelium - the \"Thrombotic paradox\" of hypertension (or \"Birmingham paradox\") revisited","volume":"41","author":"Lip","year":"2003","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013470","article-title":"Low-dose aspirin treatment attenuates male rat salt-sensitive hypertension via platelet cyclooxygenase 1 and complement cascade pathway","volume":"9","author":"Jiang","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"10.1016\/j.numecd.2024.08.020_bib32","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.numecd.2024.08.020_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3455372","article-title":"The value of SII in predicting the mortality of patients with heart failure","volume":"2022","author":"Yuan","year":"2022","journal-title":"Dis Markers"},{"key":"10.1016\/j.numecd.2024.08.020_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2021.02.012","article-title":"Systemic immune-inflammation index and incident cardiovascular diseases among middle-aged and elderly Chinese adults: the Dongfeng-Tongji cohort study","volume":"323","author":"Xu","year":"2021","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.numecd.2024.08.020_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13230","article-title":"Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease","volume":"50","author":"Yang","year":"2020","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.numecd.2024.08.020_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131400","article-title":"Associations between systemic immunity-inflammation index and heart failure: evidence from the NHANES 1999-2018","volume":"395","author":"Zheng","year":"2024","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11906-014-0507-z","article-title":"Inflammation and hypertension: new understandings and potential therapeutic targets","volume":"17","author":"De Miguel","year":"2015","journal-title":"Curr Hypertens Rep"},{"issue":"8","key":"10.1016\/j.numecd.2024.08.020_bib38","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jch.13002","article-title":"The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension","volume":"19","author":"Wang","year":"2017","journal-title":"J Clin Hypertens"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1186\/s12872-023-03661-6","article-title":"The association between systemic inflammation markers and the prevalence of hypertension","volume":"23","author":"Jin","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"issue":"12","key":"10.1016\/j.numecd.2024.08.020_bib40","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1097\/HJH.0000000000003560","article-title":"Threshold effect of systemic immune inflammatory index on hypertension in American adults (NHANES 2017\u20132020)","volume":"41","author":"Shi","year":"2023","journal-title":"J Hypertens"},{"issue":"12","key":"10.1016\/j.numecd.2024.08.020_bib41","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1111\/bph.14389","article-title":"Monocytes as immune targets in arterial hypertension","volume":"176","author":"Wenzel","year":"2019","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneph.2013.248","article-title":"Autoimmunity in the pathogenesis of hypertension","volume":"10","author":"Rodriguez-Iturbe","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.numecd.2024.08.020_bib43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijcard.2023.03.016","article-title":"Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population","volume":"379","author":"Hua","year":"2023","journal-title":"Int J Cardiol"},{"issue":"6","key":"10.1016\/j.numecd.2024.08.020_bib44","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12975-021-00946-w","article-title":"Monocyte-to-Lymphocyte ratio in clot analysis as a marker of cardioembolic stroke etiology","volume":"13","author":"Juega","year":"2022","journal-title":"Transl Stroke Res"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib45","article-title":"Age-and gender-specific reference intervals for systemic inflammatory indicators in healthy Moroccan adults","volume":"70","author":"Jebbor","year":"2024","journal-title":"Clin Lab"},{"issue":"9","key":"10.1016\/j.numecd.2024.08.020_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162953","article-title":"Difference in leukocyte composition between women before and after menopausal age, and distinct sexual dimorphism","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.numecd.2024.08.020_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2024.08.020_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.05.013","article-title":"Obesity and hypertension","volume":"122","author":"Seravalle","year":"2017","journal-title":"Pharmacol Res"},{"issue":"11","key":"10.1016\/j.numecd.2024.08.020_bib49","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1016\/S1470-2045(14)70263-3","article-title":"Cancer-related inflammation and treatment effectiveness","volume":"15","author":"Diakos","year":"2014","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.numecd.2024.08.020_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac328","article-title":"Inflammaging as a target for healthy ageing","volume":"52","author":"Dugan","year":"2023","journal-title":"Age Ageing"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324003302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475324003302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T07:12:46Z","timestamp":1738912366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475324003302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0939475324003302"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2024.08.020","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic inflammation markers and the prevalence of hypertension in 8- to 17-year-old children and adolescents: A NHANES cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2024.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103727"}}