{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:29:56Z","timestamp":1769189396869,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009433","name":"Istituto Auxologico Italiano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.numecd.2025.103862","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T12:51:27Z","timestamp":1736513487000},"page":"103862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The soluble receptor for advanced glycation end products is independently associated with systolic blood pressure values and hypertension in children"],"prefix":"10.1016","volume":"35","author":[{"given":"Elena","family":"Dozio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tassistro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Giussani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Beba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Patti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Lieti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Antolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vianello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano M.","family":"Corsi Romanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-4149","authenticated-orcid":false,"given":"Simonetta","family":"Genovesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2025.103862_bib1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1001\/jamapediatrics.2024.1543","article-title":"Long-term cardiovascular outcomes in children and adolescents with hypertension","volume":"178","author":"Robinson","year":"2024","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.numecd.2025.103862_bib2","article-title":"Risk factors in adolescent hypertension","volume":"3","author":"Ewald","year":"2016","journal-title":"Glob Pediatr Health"},{"key":"10.1016\/j.numecd.2025.103862_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.tibs.2011.08.008","article-title":"RAGE: a single receptor fits multiple ligands","volume":"36","author":"Fritz","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.numecd.2025.103862_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1189\/jlb.1012519","article-title":"RAGE regulation and signaling in inflammation and beyond","volume":"94","author":"Kierdorf","year":"2013","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.numecd.2025.103862_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11892-017-0891-2","article-title":"Dietary advanced glycation end products and cardiometabolic risk","volume":"17","author":"Luevano-Contreras","year":"2017","journal-title":"Curr Diabetes Rep"},{"key":"10.1016\/j.numecd.2025.103862_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tcm.2005.08.003","article-title":"The RAGE axis and endothelial dysfunction: maladaptive roles in the diabetic vasculature and beyond","volume":"15","author":"Ramasamy","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.numecd.2025.103862_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pharmthera.2009.06.013","article-title":"RAGE, vascular tone and vascular disease","volume":"124","author":"Farmer","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.numecd.2025.103862_bib8","first-page":"960","article-title":"Soluble receptor for advanced glycation end-products (sRAGE) in childhood obesity: association with gene expression of RAGE and cardiometabolic markers","volume":"40","author":"Vega-Cardenas","year":"2023","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.numecd.2025.103862_bib9","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1096\/fj.08-109033","article-title":"A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)","volume":"22","author":"Raucci","year":"2008","journal-title":"Faseb J"},{"key":"10.1016\/j.numecd.2025.103862_bib10","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s00394-016-1291-0","article-title":"Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women","volume":"56","author":"Dozio","year":"2017","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.numecd.2025.103862_bib11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/jcm9020454","article-title":"Circulating irisin and esRAGE as early biomarkers of decline of metabolic Health","volume":"9","author":"Dozio","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.numecd.2025.103862_bib12","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.3390\/ijms20163942","article-title":"Association between advanced glycation end products, soluble RAGE receptor, and endothelium dysfunction, evaluated by circulating endothelial cells and endothelial progenitor cells in patients with mild and resistant hypertension","volume":"20","author":"Gryszczynska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.numecd.2025.103862_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0042-1756175","article-title":"Involvement of AGE and its receptors in the pathogenesis of hypertension in elderly people and its treatment","volume":"31","author":"Prasad","year":"2022","journal-title":"Int J Angiol"},{"key":"10.1016\/j.numecd.2025.103862_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/pedi.12095","article-title":"Soluble receptor for advanced glycation end products independently predicts cardiometabolic syndrome in Latino youth","volume":"15","author":"Brickey","year":"2014","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.numecd.2025.103862_bib15","article-title":"Soluble form of receptor for advanced glycation end products is associated with obesity and metabolic syndrome in adolescents","volume":"2014","author":"He","year":"2014","journal-title":"Internet J Endocrinol"},{"key":"10.1016\/j.numecd.2025.103862_bib16","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.2174\/1381612824666180813114127","article-title":"The possible impact of hyperuricemia on serum soluble receptor for advanced glycation end products (sRAGE) levels in teenagers: a case Control study","volume":"24","author":"Lemiesz","year":"2018","journal-title":"Curr Pharmaceut Des"},{"key":"10.1016\/j.numecd.2025.103862_bib17","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.numecd.2025.103862_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpeds.2007.09.021","article-title":"Obesity Study Group of the Italian Society of Pediatric E, Diabetology. Waist-to-height ratio, a useful index to identify high metabolic risk in overweight children","volume":"152","author":"Maffeis","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.numecd.2025.103862_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1753-4887.1981.tb06734.x","article-title":"Growth and maturation during adolescence","volume":"39","author":"Tanner","year":"1981","journal-title":"Nutr Rev"},{"key":"10.1016\/j.numecd.2025.103862_bib20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.S2.555","article-title":"National high blood pressure education Program working group on high blood pressure in C, adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"issue":"2016","key":"10.1016\/j.numecd.2025.103862_bib21","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1097\/HJH.0000000000001039","article-title":"European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents","volume":"34","author":"Lurbe","year":"2016","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2025.103862_bib22","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2025.103862_bib23","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3390\/nu14051034","article-title":"Impact of lifestyle modifications on alterations in lipid and glycemic profiles and uric acid values in a pediatric population","volume":"14","author":"Giussani","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.numecd.2025.103862_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fendo.2020.00027","article-title":"Cardiovascular risk factors associated with the metabolically healthy obese (MHO) phenotype compared to the metabolically unhealthy obese (MUO) phenotype in children","volume":"11","author":"Genovesi","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.numecd.2025.103862_bib25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2025.103862_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1542\/peds.89.3.495","article-title":"Highlights of the report of the Expert Panel on blood cholesterol levels in children and adolescents","volume":"89","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2025.103862_bib27","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.113.005666","article-title":"Effect of childhood obesity prevention programs on blood pressure: a systematic review and meta-analysis","volume":"129","author":"Cai","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2025.103862_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9845175","article-title":"Increased levels of sRAGE in diabetic CKD-G5D patients: a potential protective mechanism against AGE-related upregulation of fibroblast growth factor 23 and inflammation","volume":"2017","author":"Dozio","year":"2017","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.numecd.2025.103862_bib29","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1097\/01.hjh.0000177535.45785.64","article-title":"Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension","volume":"23","author":"Geroldi","year":"2005","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2025.103862_bib30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000501718","article-title":"Soluble receptor for advanced glycation end products and its correlation with vascular damage in adolescents with obesity","volume":"92","author":"Rodriguez-Mortera","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.numecd.2025.103862_bib31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1067\/mpd.2002.125228","article-title":"Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children","volume":"140","author":"Sorof","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.numecd.2025.103862_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0021-9150(96)05947-3","article-title":"Changes in biomechanical properties, composition of collagen and elastin, and advanced glycation endproducts of the rat aorta in relation to age","volume":"127","author":"Bruel","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2025.103862_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12933-017-0531-9","article-title":"Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells","volume":"16","author":"Ren","year":"2017","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.numecd.2025.103862_bib34","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3390\/nu16111580","article-title":"Lycopene in combination with insulin triggers antioxidant defenses and increases the expression of components that detoxify advanced glycation products in kidneys of diabetic rats","volume":"16","author":"Figueiredo","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.numecd.2025.103862_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105470","article-title":"Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy","volume":"163","author":"Ma","year":"2023","journal-title":"Neurochem Int"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532500016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532500016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:41:48Z","timestamp":1769182908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947532500016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S093947532500016X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.103862","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The soluble receptor for advanced glycation end products is independently associated with systolic blood pressure values and hypertension in children","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.103862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"103862"}}