{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:42:35Z","timestamp":1762332155621,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.numecd.2025.103906","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T11:10:20Z","timestamp":1739013020000},"page":"103906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediating role of blood metabolites in the relationship between arrhythmia and hyperthyroidism in East Asian populations"],"prefix":"10.1016","volume":"35","author":[{"given":"XueDing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiGuang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AiFang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaLing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JianPing","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YongFeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-2098","authenticated-orcid":false,"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MiaoLong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.numecd.2025.103906_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrcardio.2016.174","article-title":"Thyroid hormones and cardiovascular disease","volume":"14","author":"Jabbar","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"Suppl 2","key":"10.1016\/j.numecd.2025.103906_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00059-014-4123-0","article-title":"Arrhythmia and thyroid dysfunction","volume":"40","author":"Marrakchi","year":"2015","journal-title":"Herz"},{"issue":"16","key":"10.1016\/j.numecd.2025.103906_bib3","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2018.02.045","article-title":"Thyroid hormones and cardiovascular function and diseases","volume":"71","author":"Razvi","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.numecd.2025.103906_bib4","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/cvr\/cvab292","article-title":"Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications","volume":"118","author":"Gawa\u0142ko","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.numecd.2025.103906_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/febs.17403","article-title":"Fatty-acid amide hydrolase inhibition mitigates Alzheimer\u2019s disease progression in mouse models of amyloidosis","author":"Oddi","year":"2025","journal-title":"FEBS J"},{"issue":"2","key":"10.1016\/j.numecd.2025.103906_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14283","article-title":"Understanding glucose metabolism and insulin action at the blood-brain barrier: implications for brain health and neurodegenerative diseases","volume":"241","author":"Zhu","year":"2025","journal-title":"Acta Physiol (Oxf)"},{"issue":"6","key":"10.1016\/j.numecd.2025.103906_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104108","article-title":"Oestrogen promotes the progression of adenomyosis by inhibiting CITED2 through miR-145","volume":"49","author":"Zhang","year":"2024","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"10.1016\/j.numecd.2025.103906_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70172","article-title":"Single-cell RNA-sequencing and spatial transcriptomic analysis reveal a distinct population of APOE(-) cells yielding pathological lymph node metastasis in papillary thyroid cancer","volume":"15","author":"Xiao","year":"2025","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.numecd.2025.103906_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100740","article-title":"Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD","author":"Qin","year":"2025","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.numecd.2025.103906_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2018.4635","article-title":"Assessment of the relationship between genetic determinants of thyroid function and atrial fibrillation: a mendelian randomization study","volume":"4","author":"Ellervik","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.numecd.2025.103906_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10654-021-00721-z","article-title":"Thyroid function, sex hormones and sexual function: a Mendelian randomization study","volume":"36","author":"Kjaergaard","year":"2021","journal-title":"Eur J Epidemiol"},{"issue":"8","key":"10.1016\/j.numecd.2025.103906_bib12","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/clinem\/dgaa239","article-title":"Thyroid function affects the risk of stroke via atrial fibrillation: a mendelian randomization study","volume":"105","author":"Marouli","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.numecd.2025.103906_bib13","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.numecd.2025.103906_bib14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"issue":"34","key":"10.1016\/j.numecd.2025.103906_bib15","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1093\/eurheartj\/ehab454","article-title":"Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies","volume":"42","author":"Kim","year":"2021","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.numecd.2025.103906_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41588-021-00968-y","article-title":"Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome","volume":"54","author":"Liu","year":"2022","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.numecd.2025.103906_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2023.07.012","article-title":"Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma","volume":"35","author":"Benson","year":"2023","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.numecd.2025.103906_bib18","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.numecd.2025.103906_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.numecd.2025.103906_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1089\/105072502760143863","article-title":"Hyperthyroidism and the management of atrial fibrillation","volume":"12","author":"Shimizu","year":"2002","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.numecd.2025.103906_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000490384","article-title":"European thyroid association guideline for the management of Graves' hyperthyroidism","volume":"7","author":"Kahaly","year":"2018","journal-title":"Eur Thyroid J"},{"issue":"5","key":"10.1016\/j.numecd.2025.103906_bib22","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1210\/er.2003-0033","article-title":"Thyroid hormone action in the heart","volume":"26","author":"Kahaly","year":"2005","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.numecd.2025.103906_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12020-015-0556-3","article-title":"Autoantibodies of \u03b2-adrenergic and M2 cholinergic receptors: atrial fibrillation in hyperthyroidism","volume":"49","author":"Jia","year":"2015","journal-title":"Endocrine"},{"issue":"24","key":"10.1016\/j.numecd.2025.103906_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells11244047","article-title":"Mechanisms and management of thyroid disease and atrial fibrillation: impact of atrial electrical remodeling and cardiac fibrosis","volume":"11","author":"Takawale","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.numecd.2025.103906_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2017.01.018","article-title":"Hypothalamic effects of thyroid hormone","volume":"458","author":"Zhang","year":"2017","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"10.1016\/j.numecd.2025.103906_bib26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ihj.2017.07.004","article-title":"Atrial fibrillation and hyperthyroidism: a literature review","volume":"69","author":"Reddy","year":"2017","journal-title":"Indian Heart J"},{"issue":"7","key":"10.1016\/j.numecd.2025.103906_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein","year":"2001","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.numecd.2025.103906_bib28","first-page":"327","article-title":"Amiodarone and thyroid dysfunction","volume":"61","author":"Medi\u0107","year":"2022","journal-title":"Acta Clin Croat"},{"key":"10.1016\/j.numecd.2025.103906_bib29","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJM196505202722004","article-title":"Dietary protein and renal failure","volume":"272","author":"McCracken","year":"1965","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.numecd.2025.103906_bib30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ejhf.62","article-title":"Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology","volume":"16","author":"Tarone","year":"2014","journal-title":"Eur J Heart Fail"},{"issue":"7","key":"10.1016\/j.numecd.2025.103906_bib31","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.bjp.0702944","article-title":"Novel cardiac protective effects of urea: from shark to rat","volume":"128","author":"Wang","year":"1999","journal-title":"Br J Pharmacol"},{"issue":"11","key":"10.1016\/j.numecd.2025.103906_bib32","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2005.02.068","article-title":"Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates","volume":"45","author":"Kirtane","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.numecd.2025.103906_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2362.1997.00101.x","article-title":"Moderate hyperthyroidism reduces liver amino nitrogen conversion, muscle nitrogen contents and overall nitrogen balance in rats","volume":"27","author":"Grofte","year":"1997","journal-title":"Eur J Clin Invest"},{"issue":"11","key":"10.1016\/j.numecd.2025.103906_bib34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1055\/s-2007-1012432","article-title":"An elevation of BUN\/creatinine ratio in patients with hyperthyroidism","volume":"18","author":"Aizawa","year":"1986","journal-title":"Horm Metab Res"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:37:41Z","timestamp":1762331861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475325000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0939475325000602"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.103906","relation":{},"ISSN":["0939-4753"],"issn-type":[{"type":"print","value":"0939-4753"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mediating role of blood metabolites in the relationship between arrhythmia and hyperthyroidism in East Asian populations","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.103906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103906"}}