{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:02:02Z","timestamp":1789783322903,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30-139468"],"award-info":[{"award-number":["33CS30-139468"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30-148401"],"award-info":[{"award-number":["33CS30-148401"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30_177535"],"award-info":[{"award-number":["33CS30_177535"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3247730_204523"],"award-info":[{"award-number":["3247730_204523"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss Personalized Health Network","award":["2018DRI01"],"award-info":[{"award-number":["2018DRI01"]}]},{"DOI":"10.13039\/501100024021","name":"Facult\u00e9 de Biologie et de M\u00e9decine, Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GSK plc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.numecd.2025.104201","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:35:41Z","timestamp":1750300541000},"page":"104201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physical activity trajectories and incidence of cardiovascular risk factors: a prospective study"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-6471","authenticated-orcid":false,"given":"Nour","family":"Naoum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.numecd.2025.104201_bib1","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1177\/2047487318795194","article-title":"Associations of leisure-time physical activity with cardiovascular mortality: a systematic review and meta-analysis of 44 prospective cohort studies","volume":"25","author":"Cheng","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2025.104201_bib2","article-title":"Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis","volume":"366","author":"Ekelund","year":"2019","journal-title":"Bmj"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41366-021-00970-8","article-title":"Joint associations between objectively measured physical activity volume and intensity with body fatness: the fenland study","volume":"46","author":"Lindsay","year":"2022","journal-title":"Int J Obes (Lond)."},{"issue":"7","key":"10.1016\/j.numecd.2025.104201_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002014","article-title":"Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials","volume":"4","author":"Lin","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"10.1016\/j.numecd.2025.104201_bib5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/HYPERTENSIONAHA.119.13786","article-title":"Dose-response association between level of physical activity and mortality in normal, elevated, and high blood pressure","volume":"74","author":"Joseph","year":"2019","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurjpc\/zwab154","article-title":"2021 esc guidelines on cardiovascular disease prevention in clinical practice","volume":"29","author":"Visseren","year":"2022","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/eurjpc\/zwab007","article-title":"Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how: a position statement from the secondary prevention and rehabilitation section of the European association of preventive cardiology","volume":"29","author":"Hansen","year":"2022","journal-title":"Eur J Prev Cardiol"},{"issue":"2","key":"10.1016\/j.numecd.2025.104201_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/eurpub\/ckz159","article-title":"The decline in physical activity in aging people is not modified by gender or the presence of cardiovascular disease","volume":"30","author":"Achttien","year":"2020","journal-title":"Eur J Publ Health"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19010504","article-title":"Changes in the frequency of moderate-to-vigorous physical activity and subsequent risk of all-cause and cardiovascular disease mortality","volume":"19","author":"Choi","year":"2022","journal-title":"Int J Environ Res Publ Health"},{"issue":"15","key":"10.1016\/j.numecd.2025.104201_bib10","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/eurheartj\/ehz768","article-title":"Changes in exercise frequency and cardiovascular outcomes in older adults","volume":"41","author":"Kim","year":"2020","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib11","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1186\/s12889-020-09747-6","article-title":"Long-term incidence of cardiovascular outcomes in the middle-aged and elderly with different patterns of physical activity: tehran lipid and glucose study","volume":"20","author":"Naseri","year":"2020","journal-title":"BMC Public Health"},{"issue":"15","key":"10.1016\/j.numecd.2025.104201_bib12","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1177\/2047487317721021","article-title":"Impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality: the Copenhagen city heart study","volume":"24","author":"Schnohr","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2025.104201_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2261-8-6","article-title":"The colaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome","volume":"8","author":"Firmann","year":"2008","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"10.1016\/j.numecd.2025.104201_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/oxfordjournals.aje.a009427","article-title":"Data-based approach for developing a physical activity frequency questionnaire","volume":"147","author":"Bernstein","year":"1998","journal-title":"Am J Epidemiol"},{"issue":"6","key":"10.1016\/j.numecd.2025.104201_bib15","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2105\/AJPH.89.6.862","article-title":"Definition and prevalence of sedentarism in an urban population","volume":"89","author":"Bernstein","year":"1999","journal-title":"Am J Publ Health"},{"key":"10.1016\/j.numecd.2025.104201_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ypmed.2013.11.005","article-title":"Eleven-year physical activity trends in a Swiss urban area","volume":"59","author":"Guessous","year":"2014","journal-title":"Prev Med"},{"issue":"9","key":"10.1016\/j.numecd.2025.104201_bib17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00592-018-1161-8","article-title":"Accelerometer-derived physical activity in those with cardio-metabolic disease compared to healthy adults: a UK biobank study of 52,556 participants","volume":"55","author":"Cassidy","year":"2018","journal-title":"Acta Diabetol"},{"issue":"6","key":"10.1016\/j.numecd.2025.104201_bib18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1249\/MSS.0b013e31820513be","article-title":"Validation of the genea accelerometer","volume":"43","author":"Esliger","year":"2011","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib19","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1038\/s41598-023-29872-7","article-title":"Comparison of different software for processing physical activity measurements with accelerometry","volume":"13","author":"Verhoog","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.numecd.2025.104201_bib20","first-page":"188","article-title":"Ggir: a research community\u2013driven open source R package for generating physical activity and sleep outcomes from multi-day raw accelerometer data","volume":"2","author":"Migueles","year":"2019","journal-title":"JMPB"},{"issue":"4","key":"10.1016\/j.numecd.2025.104201_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061691","article-title":"Separating movement and gravity components in an acceleration signal and implications for the assessment of human daily physical activity","volume":"8","author":"van Hees","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.numecd.2025.104201_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167472","article-title":"Estimation of physical activity energy expenditure during free-living from wrist accelerometry in UK adults","volume":"11","author":"White","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12966-023-01540-z","article-title":"Trajectories of physical activity from mid to older age in women: 21 Years of data from the Australian longitudinal study on women's health","volume":"21","author":"Nemoto","year":"2024","journal-title":"Int J Behav Nutr Phys Activ"},{"issue":"5","key":"10.1016\/j.numecd.2025.104201_bib24","first-page":"335","article-title":"[Inverse probability weighting (Ipw) for evaluating and \"correcting\" selection bias]","volume":"38","author":"Narduzzi","year":"2014","journal-title":"Epidemiol Prev"},{"issue":"2","key":"10.1016\/j.numecd.2025.104201_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-057692","article-title":"Concurrent changes in physical activity and body mass index among 66 852 public sector employees over a 16-year follow-up: multitrajectory analysis of a cohort study in Finland","volume":"12","author":"Tiusanen","year":"2022","journal-title":"BMJ Open"},{"issue":"12","key":"10.1016\/j.numecd.2025.104201_bib26","article-title":"Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus","volume":"12","author":"Hemmingsen","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.numecd.2025.104201_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112611","article-title":"Prevention of type 2 diabetes by lifestyle changes: a systematic review and meta-analysis","volume":"11","author":"Uusitupa","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.numecd.2025.104201_bib28","article-title":"Effect of leisure-time physical activity on blood pressure in people with hypertension: a systematic review and meta-analysis","volume":"13","author":"Shariful","year":"2023","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.numecd.2025.104201_bib29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/HYPERTENSIONAHA.116.08994","article-title":"Dose-response association between physical activity and incident hypertension: a systematic review and meta-analysis of cohort studies","volume":"69","author":"Liu","year":"2017","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.numecd.2025.104201_bib30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41366-021-01033-8","article-title":"Associations of changes in physical activity and discretionary screen time with incident obesity and adiposity changes: longitudinal findings from the UK biobank","volume":"46","author":"Paudel","year":"2022","journal-title":"Int J Obes (Lond)."}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325003552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325003552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:17:58Z","timestamp":1760221078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475325003552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0939475325003552"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104201","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical activity trajectories and incidence of cardiovascular risk factors: a prospective study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104201"}}