{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:07:34Z","timestamp":1781906854915,"version":"3.54.5"},"reference-count":10,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.numecd.2025.104206","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T02:40:12Z","timestamp":1750473612000},"page":"104206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["A new plasma ceramide 24-based risk score predicts overall mortality and nonfatal myocardial infarction in patients with suspected or known coronary artery disease"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-6329","authenticated-orcid":false,"given":"Alessandro","family":"Mantovani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonapace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Morandin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Lunardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Salgarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Molon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.numecd.2025.104206_bib1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41569-021-00536-1","article-title":"Ceramides and other sphingolipids as drivers of cardiovascular disease","volume":"18","author":"Choi","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.numecd.2025.104206_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.570628","article-title":"Ceramides and 2eramide scores: clinical applications for cardiometabolic risk stratification","volume":"11","author":"Hilvo","year":"2020","journal-title":"Front Endocrinol"},{"issue":"25","key":"10.1016\/j.numecd.2025.104206_bib3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/eurheartj\/ehw148","article-title":"Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol","volume":"37","author":"Laaksonen","year":"2016","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.numecd.2025.104206_bib4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jacl.2020.01.005","article-title":"Ceramides and risk of major adverse cardiovascular events: a meta-analysis of longitudinal studies","volume":"14","author":"Mantovani","year":"2020","journal-title":"J Clin Lipidol"},{"issue":"3","key":"10.1016\/j.numecd.2025.104206_bib5","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/dom.16156","article-title":"Ceramide-based risk score CERT-1 improves risk prediction for overall mortality and adverse cardiovascular outcomes in patients with and without cardiovascular disease: a prospective cohort study","volume":"27","author":"Mantovani","year":"2025","journal-title":"Diabetes Obes Metabol"},{"key":"10.1016\/j.numecd.2025.104206_bib6","article-title":"Basal and post-stress ceramide-based risk score CERT1 predicts all-cause mortality and nonfatal myocardial infarction in patients with suspected or established coronary artery disease undergoing stress myocardial perfusion scintigraphy","author":"Mantovani","year":"2024","journal-title":"Nutr Metab Cardiovasc Dis [Internet]"},{"issue":"9","key":"10.1016\/j.numecd.2025.104206_bib7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1194\/jlr.C088377","article-title":"The ceramide ratio: a predictor of cardiometabolic risk1","volume":"59","author":"Tippetts","year":"2018","journal-title":"J Lipid Res"},{"issue":"10","key":"10.1016\/j.numecd.2025.104206_bib8","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2337\/db23-0052","article-title":"Ceramides as risk markers for future cardiovascular events and all-cause mortality in long-standing type 1 diabetes","volume":"72","author":"Wretlind","year":"2023","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.numecd.2025.104206_bib9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s12325-025-03121-x","article-title":"Liver-kidney-metabolic health, sex, and menopause impact total scores and monovessel vs. Multivessel coronary artery calcification","volume":"42","author":"Bagheri Lankarani","year":"2025","journal-title":"Adv Ther"},{"issue":"11","key":"10.1016\/j.numecd.2025.104206_bib10","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/17474124.2024.2435504","article-title":"MASLD: predictive value for liver-related events and extra-hepatic complications","volume":"18","author":"Jamalinia","year":"2024","journal-title":"Expet Rev Gastroenterol Hepatol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325003606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325003606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T01:00:21Z","timestamp":1763600421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475325003606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0939475325003606"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104206","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new plasma ceramide 24-based risk score predicts overall mortality and nonfatal myocardial infarction in patients with suspected or known coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104206"}}