{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:02:46Z","timestamp":1773889366004,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.numecd.2025.104457","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:27:41Z","timestamp":1762597661000},"page":"104457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of leukocyte count with atherosclerotic cardiovascular disease in patients with genetically defined familial hypercholesterolaemia"],"prefix":"10.1016","volume":"36","author":[{"given":"Seyed Saeed","family":"Tamehri Zadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7658-5197","authenticated-orcid":false,"given":"Dick C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald F.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2025.104457_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41569-023-00892-0","article-title":"International Atherosclerosis society guidance for implementing best practice in the care of familial hypercholesterolaemia","volume":"20","author":"Watts","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.numecd.2025.104457_bib2","first-page":"2525","article-title":"Inflammation during the life cycle of the atherosclerotic plaque","volume":"117","author":"Libby","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.numecd.2025.104457_bib3","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1093\/eurheartj\/ehad649","article-title":"Neutrophil counts and cardiovascular disease","volume":"44","author":"Luo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2025.104457_bib4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12933-025-02721-9","article-title":"Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort","volume":"24","author":"Qin","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.numecd.2025.104457_bib5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/ATVBAHA.118.310945","article-title":"Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK biobank","volume":"38","author":"Welsh","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.numecd.2025.104457_bib6","article-title":"White blood cells and coronary heart disease: a mendelian randomization study","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.numecd.2025.104457_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ijcard.2015.08.146","article-title":"Elevated lipoprotein (a), hypertension and renal insufficiency as predictors of coronary artery disease in patients with genetically confirmed heterozygous familial hypercholesterolemia","volume":"201","author":"Chan","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.numecd.2025.104457_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejim.2024.12.002","article-title":"Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis","volume":"132","author":"Bosco","year":"2025","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.numecd.2025.104457_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14326","article-title":"Hypercholesterolemia and inflammation\u2014Cooperative cardiovascular risk factors","volume":"55","author":"Gallo","year":"2025","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.numecd.2025.104457_bib10","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.jacc.2023.03.401","article-title":"Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease","volume":"81","author":"Gumuser","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2025.104457_bib11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/joim.20080","article-title":"Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases","volume":"297","author":"Wu","year":"2025","journal-title":"J Intern Med"},{"key":"10.1016\/j.numecd.2025.104457_bib12","article-title":"Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data","volume":"342","author":"Wensley","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.numecd.2025.104457_bib13","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/ijms25021082","article-title":"The role of pro-inflammatory cytokines in the pathogenesis of cardiovascular disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.numecd.2025.104457_bib14","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1093\/cvr\/cvad069","article-title":"Monocyte heterogeneity in cardiovascular disease","volume":"119","author":"Ruder","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.numecd.2025.104457_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s40119-024-00376-3","article-title":"Recent advances in targeted management of inflammation in atherosclerosis: a narrative review","volume":"13","author":"Zubir\u00e1n","year":"2024","journal-title":"Cardiol Ther"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532500612X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947532500612X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:09:51Z","timestamp":1773875391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947532500612X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S093947532500612X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104457","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of leukocyte count with atherosclerotic cardiovascular disease in patients with genetically defined familial hypercholesterolaemia","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104457"}}