{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:25:26Z","timestamp":1780431926293,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004572","name":"National Health and Family Planning Commission of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005045","name":"Ministry of Finance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000087","name":"National Science Foundation Division of Polar Programs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.numecd.2025.104486","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:54:21Z","timestamp":1764662061000},"page":"104486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["High atherogenic index of plasma increased the risk of new-onset hypertension"],"prefix":"10.1016","volume":"36","author":[{"given":"Zhong-Yuan","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-Hu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Xian","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Lin","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2700","authenticated-orcid":false,"given":"Zhi-Yu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2025.104486_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.14","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"10.1016\/j.numecd.2025.104486_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2016.19043","article-title":"Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015","volume":"317","author":"Forouzanfar","year":"2017","journal-title":"JAMA, J Am Med Assoc"},{"issue":"9455","key":"10.1016\/j.numecd.2025.104486_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"LANCET (N AM ED)"},{"issue":"11","key":"10.1016\/j.numecd.2025.104486_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008888","article-title":"Trends in prevalence and control of hypertension according to the 2017 American college of cardiology\/american heart association (ACC\/AHA) guideline","volume":"7","author":"Dorans","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.numecd.2025.104486_bib5","first-page":"1","volume":"vol. 289","author":"Fryar","year":"2017"},{"issue":"22","key":"10.1016\/j.numecd.2025.104486_bib6","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","article-title":"Status of hypertension in China: results from the China hypertension survey, 2012-2015","volume":"137","author":"Wang","year":"2018","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.numecd.2025.104486_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0009-9120(01)00263-6","article-title":"The plasma parameter log (TG\/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apob-lipoprotein-depleted plasma (FER(HDL))","volume":"34","author":"Dobiasova","year":"2001","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12872-023-03451-0","article-title":"The association between atherogenic index of plasma and all-cause mortality and cardiovascular disease-specific mortality in hypertension patients: a retrospective cohort study of NHANES","volume":"23","author":"Duiyimuhan","year":"2023","journal-title":"BMC CARDIOVASC DISOR"},{"issue":"5","key":"10.1016\/j.numecd.2025.104486_bib9","article-title":"High-density lipoprotein (HDL) triglyceride and oxidized HDL: new lipid biomarkers of lipoprotein-related atherosclerotic cardiovascular disease","volume":"9","author":"Ito","year":"2020","journal-title":"ANTIOXIDANTS-BASEL"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12933-024-02330-y","article-title":"Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data","volume":"23","author":"Sun","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"20","key":"10.1016\/j.numecd.2025.104486_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13203249","article-title":"Atherogenic index of plasma predicts obstructive coronary artery disease in patients with stable angina pectoris","volume":"13","author":"Kurklu","year":"2023","journal-title":"Diagnostics"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12933-024-02375-z","article-title":"Association between the atherogenic index of plasma trajectory and risk of heart failure among hypertensive patients: a prospective cohort study","volume":"23","author":"Zheng","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.numecd.2025.104486_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1966680","article-title":"Association of systemic immune inflammation index with estimated pulse wave velocity, atherogenic index of plasma, triglyceride-glucose index, and cardiovascular disease: a large cross-sectional study","volume":"2023","author":"Xiao","year":"2023","journal-title":"Mediat Inflamm"},{"issue":"3","key":"10.1016\/j.numecd.2025.104486_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/00325481.2022.2039007","article-title":"Poorly controlled hypertension is associated with elevated serum uric acid to HDL-Cholesterol ratio: a cross-sectional cohort study","volume":"134","author":"Aktas","year":"2022","journal-title":"Postgrad Med J"},{"issue":"2","key":"10.1016\/j.numecd.2025.104486_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/03007995.2025.2463952","article-title":"The systemic immune inflammation index is a reliable and novel risk factor for metabolic dysfunction-associated fatty liver disease","volume":"41","author":"Kosekli","year":"2025","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2024.2303999","article-title":"The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China","volume":"46","author":"Yuan","year":"2024","journal-title":"Clin Exp Hypertens"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib17","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1038\/s41598-021-89307-z","article-title":"Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study","volume":"11","author":"Li","year":"2021","journal-title":"SCI REP-UK"},{"key":"10.1016\/j.numecd.2025.104486_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.938363","article-title":"Dyslipidemia and the prevalence of hypertension: a cross-sectional study based on Chinese adults without type 2 diabetes mellitus","volume":"9","author":"Cheng","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010200","article-title":"Protocol for the China PEACE (Patient-centered evaluative assessment of cardiac events) million persons project pilot","volume":"6","author":"Lu","year":"2016","journal-title":"BMJ Open"},{"issue":"6","key":"10.1016\/j.numecd.2025.104486_bib20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.numecd.2025.104486_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA, J Am Med Assoc"},{"issue":"7","key":"10.1016\/j.numecd.2025.104486_bib22","first-page":"579","article-title":"[2010 Chinese guidelines for the management of hypertension]","volume":"39","author":"Liu","year":"2011","journal-title":"Zhonghua Xinxueguanbing Zazhi"},{"key":"10.1016\/j.numecd.2025.104486_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2288-12-70","article-title":"Evaluation of the propensity score methods for estimating marginal odds ratios in case of small sample size","volume":"12","author":"Pirracchio","year":"2012","journal-title":"BMC Med Res Methodol"},{"issue":"5","key":"10.1016\/j.numecd.2025.104486_bib24","first-page":"9","article-title":"A study of effects of MultiCollinearity in the multivariable analysis","volume":"4","author":"Yoo","year":"2014","journal-title":"Int J Appl Sci Technol"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12874-021-01426-3","article-title":"Mediation analysis methods used in observational research: a scoping review and recommendations","volume":"21","author":"Rijnhart","year":"2021","journal-title":"BMC Med Res Methodol"},{"issue":"21","key":"10.1016\/j.numecd.2025.104486_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.21037\/atm.2016.11.11","article-title":"Causal mediation analysis in the context of clinical research","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med"},{"issue":"3","key":"10.1016\/j.numecd.2025.104486_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/HYPERTENSIONAHA.117.10476","article-title":"Central and brachial blood pressures, statins, and low-density lipoprotein cholesterol: a mediation analysis","volume":"71","author":"Lamarche","year":"2018","journal-title":"Hypertension"},{"issue":"9841","key":"10.1016\/j.numecd.2025.104486_bib28","first-page":"581","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials","volume":"380","author":"Mihaylova","year":"2012","journal-title":"LANCET (N AM ED)"},{"key":"10.1016\/j.numecd.2025.104486_bib29","article-title":"Differences in lipid profiles and atherogenic indices between hypertensive and normotensive populations: a cross-sectional study of 11 Chinese cities","volume":"9","author":"Cheng","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.numecd.2025.104486_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/08037051.2019.1583060","article-title":"Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects","volume":"28","author":"Choudhary","year":"2019","journal-title":"Blood Press"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12944-021-01505-w","article-title":"Visceral adiposity index and atherogenic index of plasma as useful predictors of risk of cardiovascular diseases: evidence from a cohort study in Iran","volume":"20","author":"Hamzeh","year":"2021","journal-title":"Lipids Health Dis"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12944-023-01853-9","article-title":"Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional study","volume":"22","author":"Tan","year":"2023","journal-title":"Lipids Health Dis"},{"issue":"2","key":"10.1016\/j.numecd.2025.104486_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacl.2010.02.005","article-title":"\"Atherogenic index of plasma\" (log10 triglyceride\/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events","volume":"4","author":"Onat","year":"2010","journal-title":"J Clin LipidoL"},{"issue":"3","key":"10.1016\/j.numecd.2025.104486_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20032532","article-title":"Smoke exposure reduces the protective effect of physical activity on hypertension: evidence from the national health and nutrition examination survey (NHANES) 2013-2018","volume":"20","author":"Li","year":"2023","journal-title":"Int J Environ Res Publ Health"},{"issue":"10","key":"10.1016\/j.numecd.2025.104486_bib35","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1097\/HJH.0000000000002478","article-title":"Association between secondhand smoke exposure and hypertension: nearly as large as smoking","volume":"38","author":"Skipina","year":"2020","journal-title":"J Hypertens"},{"issue":"22","key":"10.1016\/j.numecd.2025.104486_bib36","article-title":"The relationship between atherogenic index of plasma and obesity among adults in Taiwan","volume":"19","author":"Zhang","year":"2022","journal-title":"Int J Environ Res Publ Health"},{"issue":"1","key":"10.1016\/j.numecd.2025.104486_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12944-018-0686-8","article-title":"Atherogenic index of plasma is a novel and better biomarker associated with obesity: a population-based cross-sectional study in China","volume":"17","author":"Zhu","year":"2018","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.numecd.2025.104486_bib38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40885-019-0111-2","article-title":"The effect of body mass index and its interaction with family history on hypertension: a case-control study","volume":"25","author":"Li","year":"2019","journal-title":"CLIN HYPERTENS"},{"key":"10.1016\/j.numecd.2025.104486_bib39","article-title":"Dose-response relationship between body mass index and hypertension: a cross-sectional study from eastern China","volume":"46","author":"Yuan","year":"2024","journal-title":"Prev Med Rep"},{"issue":"4","key":"10.1016\/j.numecd.2025.104486_bib40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.123.21719","article-title":"Obesity in hypertension: the role of the expanding waistline over the years and insights into the future","volume":"81","author":"Jia","year":"2024","journal-title":"Hypertension"},{"issue":"20","key":"10.1016\/j.numecd.2025.104486_bib41","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000001186","article-title":"A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American heart association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325006416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325006416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:39:19Z","timestamp":1773952759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475325006416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0939475325006416"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104486","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High atherogenic index of plasma increased the risk of new-onset hypertension","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104486"}}