{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:21:39Z","timestamp":1774002099727,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173318"],"award-info":[{"award-number":["82173318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.numecd.2025.104530","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:28:00Z","timestamp":1766017680000},"page":"104530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of lipoprotein subclasses with risk of cardiovascular disease in individuals with MASLD"],"prefix":"10.1016","volume":"36","author":[{"given":"Shiru","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hancheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuya","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-8760","authenticated-orcid":false,"given":"Bin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib1","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1016\/j.jhep.2023.09.033","article-title":"Transitioning from NAFLD to MAFLD and MASLD: consistent prevalence and risk factors in a Chinese cohort","volume":"80","author":"Yang","year":"2024","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib2","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/gutjnl-2023-330595","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher","year":"2024","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.numecd.2025.104530_bib4","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1016\/j.jhep.2023.08.026","article-title":"99% of patients with NAFLD meet MASLD criteria and natural history is therefore identical","volume":"80","author":"Hagstrom","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2025.104530_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154433","article-title":"MAFLD and risk of CKD","volume":"115","author":"Sun","year":"2021","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.numecd.2025.104530_bib6","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jhep.2023.08.018","article-title":"Familial coaggregation of MASLD with hepatocellular carcinoma and adverse liver outcomes: nationwide multigenerational cohort study","volume":"79","author":"Ebrahimi","year":"2023","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.numecd.2025.104530_bib7","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.numecd.2025.104530_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12933-022-01697-0","article-title":"Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention","volume":"21","author":"Zhou","year":"2022","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"10.1016\/j.numecd.2025.104530_bib9","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.cgh.2020.12.022","article-title":"Metabolic dysfunction-associated fatty liver disease and incident cardiovascular disease risk: a nationwide cohort study","volume":"19","author":"Lee","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s12072-023-10543-8","article-title":"An international multidisciplinary consensus statement on MAFLD and the risk of CVD","volume":"17","author":"Zhou","year":"2023","journal-title":"Hepatol Int"},{"issue":"7","key":"10.1016\/j.numecd.2025.104530_bib11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/CIRCRESAHA.116.305485","article-title":"HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export","volume":"116","author":"Du","year":"2015","journal-title":"Circ Res"},{"issue":"20","key":"10.1016\/j.numecd.2025.104530_bib12","doi-asserted-by":"crossref","first-page":"11962","DOI":"10.1021\/acs.analchem.8b02412","article-title":"Quantitative lipoprotein subclass and low molecular weight metabolite analysis in human serum and plasma by (1)H NMR spectroscopy in a multilaboratory trial","volume":"90","author":"Jimenez","year":"2018","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.numecd.2025.104530_bib13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/CIRCGENETICS.114.000216","article-title":"Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics","volume":"8","author":"Soininen","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib14","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jhep.2020.10.019","article-title":"Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR-based lipoprotein profiling","volume":"74","author":"Xia","year":"2021","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.numecd.2025.104530_bib15","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1111\/dom.15224","article-title":"Associations of lipoprotein subclasses with risk of all-cause and cardiovascular disease mortality in individuals with type 2 diabetes: a prospective cohort study","volume":"25","author":"Li","year":"2023","journal-title":"Diabetes Obes Metabol"},{"issue":"4","key":"10.1016\/j.numecd.2025.104530_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2021.04.044","article-title":"Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis","volume":"75","author":"Selvaraj","year":"2021","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.numecd.2025.104530_bib17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population","volume":"186","author":"Fry","year":"2017","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.numecd.2025.104530_bib18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","volume":"81","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2025.104530_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-230X-6-33","article-title":"The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population","volume":"6","author":"Bedogni","year":"2006","journal-title":"BMC Gastroenterol"},{"issue":"5","key":"10.1016\/j.numecd.2025.104530_bib20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/EJE-14-0112","article-title":"External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals","volume":"171","author":"Cuthbertson","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"10.1016\/j.numecd.2025.104530_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2018.10.059","article-title":"High-density lipoprotein particle subfractions in heart failure with preserved or reduced ejection fraction","volume":"73","author":"Hunter","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2025.104530_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.atherosclerosis.2016.01.012","article-title":"High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort","volume":"246","author":"McGarrah","year":"2016","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1016\/j.numecd.2025.104530_bib24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.114.013116","article-title":"Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts","volume":"131","author":"Wurtz","year":"2015","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.numecd.2025.104530_bib25","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.113.002500","article-title":"Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study","volume":"129","author":"Stegemann","year":"2014","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.numecd.2025.104530_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001606","article-title":"Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons","volume":"11","author":"Fischer","year":"2014","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2025.104530_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101092","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"42","author":"Deprince","year":"2020","journal-title":"Mol Metabol"},{"issue":"9943","key":"10.1016\/j.numecd.2025.104530_bib28","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(14)61177-6","article-title":"Triglycerides and cardiovascular disease","volume":"384","author":"Nordestgaard","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2025.104530_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12933-014-0159-y","article-title":"Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor","volume":"13","author":"Tenenbaum","year":"2014","journal-title":"Cardiovasc Diabetol"},{"issue":"9841","key":"10.1016\/j.numecd.2025.104530_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials","volume":"380","author":"Cholesterol Treatment Trialists","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.numecd.2025.104530_bib31","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.5551\/jat.63937","article-title":"Association between intermediate-density lipoprotein particles and the progression of carotid atherosclerosis: a community-based cohort study","volume":"30","author":"Liu","year":"2023","journal-title":"J Atherosclerosis Thromb"},{"key":"10.1016\/j.numecd.2025.104530_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejim.2024.11.020","article-title":"Clarifications and enhancements for cardiovascular risk study in metabolic dysfunction-associated steatotic liver disease","volume":"132","author":"Wu","year":"2025","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.numecd.2025.104530_bib33","article-title":"Association of neutrophil-to-lymphocyte ratio and risk of all-cause and cardiovascular mortality in adults with metabolic dysfunction-associated steatotic liver disease: a population-based cohort study","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1016\/j.numecd.2025.104530_bib34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12933-024-02434-5","article-title":"Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk: a comprehensive review","volume":"23","author":"Zheng","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.numecd.2025.104530_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2024.09.009","article-title":"Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation","volume":"37","author":"Lam","year":"2025","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.numecd.2025.104530_bib37","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.clinthera.2021.07.012","article-title":"Current and emerging biomarkers and imaging modalities for nonalcoholic fatty liver disease: clinical and research applications","volume":"43","author":"Hydes","year":"2021","journal-title":"Clin Ther"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325006854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475325006854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:42:19Z","timestamp":1773992539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475325006854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0939475325006854"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104530","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of lipoprotein subclasses with risk of cardiovascular disease in individuals with MASLD","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2025.104530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104530"}}