{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:10:38Z","timestamp":1791378638567,"version":"4.3.2"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017336","name":"Government of Italy Commission for the Selection of Excellence University Departments","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.numecd.2026.104543","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:20:06Z","timestamp":1767658806000},"page":"104543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low density lipoprotein target achivement in very high and extreme cardiovascular risk patients during a cardiac rehabilitation program"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-6264","authenticated-orcid":false,"given":"Alessandro","family":"Maloberti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boma Patricia","family":"Diri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bellomare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tognola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atea","family":"Shkodra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Algeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Pio","family":"Prencipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Brollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Ruzzenenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Alloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Luongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Riccobono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giannattasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.numecd.2026.104543_bib1","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1093\/eurheartj\/ehae466","article-title":"European society of cardiology: the 2023 Atlas of cardiovascular disease statistics","volume":"45","author":"Timmis","year":"2024","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.numecd.2026.104543_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2019","journal-title":"Eur Heart J"},{"issue":"39","key":"10.1016\/j.numecd.2026.104543_bib3","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","article-title":"2016 ESC\/EAS guidelines for the management of dyslipidaemias","volume":"37","author":"Catapano","year":"2016","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.numecd.2026.104543_bib4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/eurjpc\/zwaa047","article-title":"EU-Wide cross-sectional observational study of lipid-modifying therapy use in secondary and primary care: the DA VINCI study","volume":"28","author":"Ray","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.numecd.2026.104543_bib5","article-title":"Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study","volume":"29","author":"Ray","year":"2023","journal-title":"Lancet Reg Health Europe"},{"issue":"10 Suppl 2","key":"10.1016\/j.numecd.2026.104543_bib6","first-page":"e17","article-title":"The rehabilitation phase. PubMed","volume":"20","author":"Pedretti","year":"2019"},{"key":"10.1016\/j.numecd.2026.104543_bib7","article-title":"Low awareness of cardiovascular risk factor among patients admitted in cardiac rehabilitation unit","volume":"28","author":"Conte","year":"2021","journal-title":"High Blood Pres Cardiovasc Prev"},{"issue":"23","key":"10.1016\/j.numecd.2026.104543_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11237057","article-title":"Achievement of low-density lipoprotein cholesterol targets in cardiac rehabilitation: impact of the 2019 ESC\/EAS Dyslipidaemia guidelines","volume":"11","author":"Haegele","year":"2022","journal-title":"J Clin Med"},{"issue":"6","key":"10.1016\/j.numecd.2026.104543_bib9","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s11845-021-02885-9","article-title":"Dyslipidaemia management in the cardiac rehabilitation clinic of a tertiary referral centre: analysis of the impact of new ESC guidance on LDL-C target achievement","volume":"191","author":"McCaughey","year":"2022","journal-title":"Ir J Med Sci"},{"issue":"19","key":"10.1016\/j.numecd.2026.104543_bib10","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/eurheartj\/ehab771","article-title":"Extreme cardiovascular risk - do we need a new risk category?","volume":"43","author":"Dyrbus","year":"2022","journal-title":"Eur Heart J"},{"issue":"18","key":"10.1016\/j.numecd.2026.104543_bib11","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"36","key":"10.1016\/j.numecd.2026.104543_bib12","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Christiaan","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2026.104543_bib13","series-title":"Modifica Registri di monitoraggio REPATHA E PRALUENT (INIBITORI DI PCSK-9)","year":"2022"},{"issue":"15","key":"10.1016\/j.numecd.2026.104543_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/eurjpc\/zwae199","article-title":"Use of combination therapy is associated with improved LDL-cholesterol management: 1-year follow-up results from the European observational SANTORINI study","volume":"31","author":"Ray","year":"2024","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.numecd.2026.104543_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.56095\/eaj.v2i1.26","article-title":"Lipid-lowering treatment and LDL-C goal attainment in high and very high cardiovascular risk patients: evidence from the SANTORINI study-the Italian experience","volume":"2","author":"Arca","year":"2023","journal-title":"Eur Atheroscl J"},{"key":"10.1016\/j.numecd.2026.104543_bib16","article-title":"Challenges in achieving LDL-C goals: insights from the Italian SANTORINI study cohort","author":"Arca","year":"2025","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2026.104543_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131659","article-title":"Achievement of target LDL-cholesterol level in patients with acute coronary syndrome undergoing percutaneous coronary intervention: the JET-LDL registry","volume":"397","author":"Ferlini","year":"2024","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.numecd.2026.104543_bib18","doi-asserted-by":"crossref","DOI":"10.5334\/gh.1170","article-title":"The effect of cardiac rehabilitation on lipid levels in patients with coronary heart disease. A systematic review and meta-analysis","volume":"17","author":"Wu","year":"2022","journal-title":"Global Heart"},{"issue":"2","key":"10.1016\/j.numecd.2026.104543_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.numecd.2024.08.006","article-title":"Secondary prevention and extreme cardiovascular risk evaluation (SEVERE-0): prevalence of extreme cardiovascular risk in cardiological rehabilitation patients and its impact on functional improvement","volume":"35","author":"Tognola","year":"2025","journal-title":"Nutr Metabol Cardiovasc Dis"},{"issue":"6","key":"10.1016\/j.numecd.2026.104543_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s40292-023-00607-z","article-title":"Secondary prevention and extreme cardiovascular risk evaluation (SEVERE-1), focus on prevalence and associated risk factors: the study protocol","volume":"30","author":"Maloberti","year":"2023","journal-title":"High Blood Pres Cardiovasc Prev"},{"issue":"8","key":"10.1016\/j.numecd.2026.104543_bib21","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s12325-024-02916-8","article-title":"Differential adherence to free and single-pill combination of Rosuvastatin\/Ezetimibe: findings from a real-world analysis in Italy","volume":"41","author":"Perez","year":"2024","journal-title":"Adv Ther"},{"issue":"7","key":"10.1016\/j.numecd.2026.104543_bib22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0002-9149(00)01519-8","article-title":"Improved treatment of coronary heart disease by implementation of a Cardiac Hospitalization Atherosclerosis management program (CHAMP)","volume":"87","author":"Fonarow","year":"2001","journal-title":"Am J Cardiol"},{"issue":"10","key":"10.1016\/j.numecd.2026.104543_bib23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.amjcard.2011.01.013","article-title":"Adherence to Statin therapy in elderly patients after hospitalization for coronary revascularization","volume":"107","author":"Kulik","year":"2011","journal-title":"Am J Cardiol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:26:54Z","timestamp":1773912414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475326000050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0939475326000050"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104543","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low density lipoprotein target achivement in very high and extreme cardiovascular risk patients during a cardiac rehabilitation program","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104543"}}