{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:00:07Z","timestamp":1790085607440,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000139","name":"United States Environmental Protection Agency","doi-asserted-by":"publisher","award":["RD83543601"],"award-info":[{"award-number":["RD83543601"]}],"id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["K01 HL151673"],"award-info":[{"award-number":["K01 HL151673"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES014930"],"award-info":[{"award-number":["R01 ES014930"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES007821"],"award-info":[{"award-number":["R01 ES007821"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35 ES031686"],"award-info":[{"award-number":["R35 ES031686"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES013744"],"award-info":[{"award-number":["R01 ES013744"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1U2C ES026553"],"award-info":[{"award-number":["1U2C ES026553"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P01 ES02284401"],"award-info":[{"award-number":["P01 ES02284401"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100025940","name":"National Network of Public Health Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100025940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.numecd.2026.104574","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:13:51Z","timestamp":1769184831000},"page":"104574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic age acceleration in adolescence: cross-sectional associations with dietary intake and prospective associations with cardiometabolic risk indicators in a Mexico City cohort"],"prefix":"10.1016","volume":"36","author":[{"given":"Jennifer T.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn M.","family":"Goodrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C.","family":"Dolinoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"T\u00e9llez-Rojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Cantoral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libni A.","family":"Torres-Olascoaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricruz","family":"Tolentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Ruiz-Narv\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-3729","authenticated-orcid":false,"given":"Erica C.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10053","key":"10.1016\/j.numecd.2026.104574_bib1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(16)31679-8","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: a systematic analysis for the global burden of disease study 2015","volume":"388","author":"Forouzanfar","year":"2016","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.numecd.2026.104574_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s42255-020-0183-z","article-title":"Childhood obesity and the associated rise in cardiometabolic complications","volume":"2","author":"Caprio","year":"2020","journal-title":"Nat Metab"},{"issue":"6","key":"10.1016\/j.numecd.2026.104574_bib3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"10","key":"10.1016\/j.numecd.2026.104574_bib13","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"issue":"7","key":"10.1016\/j.numecd.2026.104574_bib14","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.18632\/aging.101508","article-title":"Epigenetic clock for skin and blood cells applied to hutchinson gilford progeria syndrome and ex vivo studies","volume":"10","author":"Horvath","year":"2018","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.numecd.2026.104574_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.numecd.2026.104574_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging"},{"issue":"38","key":"10.1016\/j.numecd.2026.104574_bib17","doi-asserted-by":"crossref","first-page":"23329","DOI":"10.1073\/pnas.1820843116","article-title":"The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells","volume":"117","author":"McEwen","year":"2020","journal-title":"Proc Natl Acad Sci"},{"issue":"22","key":"10.1016\/j.numecd.2026.104574_bib18","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.18632\/aging.102399","article-title":"DNA methylation profile is a quantitative measure of biological aging in children","volume":"11","author":"Wu","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.numecd.2026.104574_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13148-019-0656-7","article-title":"The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis","volume":"11","author":"Fransquet","year":"2019","journal-title":"Clin Epigenet"},{"issue":"1","key":"10.1016\/j.numecd.2026.104574_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/ajcn\/nqab307","article-title":"Healthy eating patterns and epigenetic measures of biological age","volume":"115","author":"Kresovich","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2026.104574_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clnu.2024.12.018","article-title":"Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: a study with twins","volume":"45","author":"Ravi","year":"2025","journal-title":"Clin Nutr"},{"issue":"8","key":"10.1016\/j.numecd.2026.104574_bib7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jnutbio.2012.03.003","article-title":"Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation","volume":"23","author":"Anderson","year":"2012","journal-title":"J Nutr Biochem"},{"issue":"4","key":"10.1016\/j.numecd.2026.104574_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae026","article-title":"Body size, diet quality, and epigenetic aging: cross-sectional and longitudinal analyses","volume":"79","author":"Li","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"10.1016\/j.numecd.2026.104574_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13148-021-01065-x","article-title":"Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the generation R study","volume":"13","author":"Monasso","year":"2021","journal-title":"Clin Epigenet"},{"issue":"4","key":"10.1016\/j.numecd.2026.104574_bib10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.tjnut.2023.01.028","article-title":"Maternal and paternal dietary quality and dietary inflammation associations with offspring DNA methylation and epigenetic biomarkers of aging in the lifeways cross-generation study","volume":"153","author":"Lecorguill\u00e9","year":"2023","journal-title":"J Nutr"},{"issue":"1","key":"10.1016\/j.numecd.2026.104574_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13330","article-title":"Nutrition in adolescents: physiology, metabolism, and nutritional needs","volume":"1393","author":"Das","year":"2017","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"10.1016\/j.numecd.2026.104574_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030427","article-title":"Early life exposure in Mexico to ENvironmental toxicants (ELEMENT) project","volume":"9","author":"Perng","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.numecd.2026.104574_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.appet.2019.104542","article-title":"Exploring dietary patterns in a Mexican adolescent population: a mixed methods approach","volume":"147","author":"Jansen","year":"2020","journal-title":"Appetite"},{"issue":"6","key":"10.1016\/j.numecd.2026.104574_bib20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.21149\/spm.v58i6.7862","article-title":"Validity of a food frequency questionnaire to assess food intake in Mexican adolescent and adult population","volume":"58","author":"Denova-Guti\u00e9rrez","year":"2016","journal-title":"Salud Publica Mex"},{"key":"10.1016\/j.numecd.2026.104574_bib22","doi-asserted-by":"crossref","DOI":"10.1249\/MSS.0000000000003498","article-title":"Associations between sleep and physical activity behavior clusters and epigenetic age acceleration in Mexican adolescents","author":"Banker","year":"2024","journal-title":"Med Sci Sports Exerc"},{"issue":"13","key":"10.1016\/j.numecd.2026.104574_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.13.e65","article-title":"Bisulfite genomic sequencing: systematic investigation of critical experimental parameters","volume":"29","author":"Grunau","year":"2001","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.numecd.2026.104574_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/epi.15.114","article-title":"Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences","volume":"8","author":"Moran","year":"2016","journal-title":"Epigenomics"},{"issue":"10","key":"10.1016\/j.numecd.2026.104574_bib25","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.numecd.2026.104574_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12864-016-3426-3","article-title":"RELIC: a novel dye-bias correction method for illumina methylation BeadChip","volume":"18","author":"Xu","year":"2017","journal-title":"BMC Genom"},{"key":"10.1016\/j.numecd.2026.104574_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol"},{"issue":"12","key":"10.1016\/j.numecd.2026.104574_bib28","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/bioinformatics\/btaa825","article-title":"Methylclock : a bioconductor package to estimate DNA methylation age","volume":"37","author":"Peleg\u00ed-Sis\u00f3","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.numecd.2026.104574_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.nutres.2020.08.005","article-title":"Greater cumulative exposure to a pro\u2010inflammatory diet is associated with higher metabolic syndrome score and blood pressure in young Mexican adults","volume":"81","author":"Betanzos-Robledo","year":"2020","journal-title":"Nutr Res"},{"issue":"10","key":"10.1016\/j.numecd.2026.104574_bib30","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3945\/jn.117.256669","article-title":"Dietary patterns exhibit sex-specific associations with adiposity and metabolic risk in a cross-sectional study in urban Mexican adolescents","volume":"147","author":"Perng","year":"2017","journal-title":"J Nutr"},{"key":"10.1016\/j.numecd.2026.104574_bib31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12966-017-0591-y","article-title":"Externalizing behavior is prospectively associated with intake of added sugar and sodium among low socioeconomic status preschoolers in a sex-specific manner","volume":"14","author":"Jansen","year":"2017","journal-title":"Int J Behav Nutr Phys Activ"},{"issue":"2","key":"10.1016\/j.numecd.2026.104574_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/ijpo.12033","article-title":"Classification of physical activity intensities using a wrist-worn accelerometer in 8\u201312-year-old children","volume":"11","author":"Chandler","year":"2016","journal-title":"Pediatr Obes"},{"issue":"23","key":"10.1016\/j.numecd.2026.104574_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800092","article-title":"Dietary intervention modifies DNA methylation age assessed by the epigenetic clock","volume":"62","author":"Sae\u2010Lee","year":"2018","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"10.1016\/j.numecd.2026.104574_bib34","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.genm.2012.10.001","article-title":"Sex and life expectancy","volume":"9","author":"Seifarth","year":"2012","journal-title":"Gend Med"},{"issue":"6","key":"10.1016\/j.numecd.2026.104574_bib35","doi-asserted-by":"crossref","first-page":"E327","DOI":"10.1016\/S2666-7568(21)00087-8","article-title":"Epigenetic age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: the population based cross-sectional RODAM study","volume":"2","author":"Chilunga","year":"2021","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.numecd.2026.104574_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13148-015-0154-5","article-title":"The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects","volume":"7","author":"Kok","year":"2015","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.numecd.2026.104574_bib37","doi-asserted-by":"crossref","unstructured":"Michels KB, Binder AM. Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals \u2013 a randomized intervention trial. Epigenetics. 19(1):2293410. doi:10.1080\/15592294.2023.2293410.","DOI":"10.1080\/15592294.2023.2293410"},{"key":"10.1016\/j.numecd.2026.104574_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.semcdb.2019.09.008","article-title":"Epigenetics and the developmental origins of health and disease: parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype","volume":"97","author":"Safi-Stibler","year":"2020","journal-title":"Semin Cell Dev Biol"},{"issue":"24","key":"10.1016\/j.numecd.2026.104574_bib38","doi-asserted-by":"crossref","first-page":"R1038","DOI":"10.1016\/j.cub.2004.11.039","article-title":"A marker for the end of adolescence","volume":"14","author":"Roenneberg","year":"2004","journal-title":"Curr Biol"},{"issue":"7","key":"10.1016\/j.numecd.2026.104574_bib41","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/jc.2018-02076","article-title":"Epigenetic age acceleration in adolescence associates with BMI, inflammation, and risk score for middle age cardiovascular disease","volume":"104","author":"Huang","year":"2019","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:05:09Z","timestamp":1790082309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475326000360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0939475326000360"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104574","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic age acceleration in adolescence: cross-sectional associations with dietary intake and prospective associations with cardiometabolic risk indicators in a Mexico City cohort","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104574","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104574"}}