{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:00:19Z","timestamp":1790085619761,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010559","name":"Children's Hospital of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7-08-JF-27"],"award-info":[{"award-number":["7-08-JF-27"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000005"],"award-info":[{"award-number":["UL1TR000005"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 RR024153"],"award-info":[{"award-number":["UL1 RR024153"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007408","name":"Medical Center, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL114857"],"award-info":[{"award-number":["5R01HL114857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21DK083654-01A1"],"award-info":[{"award-number":["1R21DK083654-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.numecd.2026.104615","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:11:04Z","timestamp":1770826264000},"page":"104615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Individual variability in insulin sensitivity, visceral fat, and cardiorespiratory fitness in response to exercise in adolescents with obesity"],"prefix":"10.1016","volume":"36","author":[{"given":"Parmis","family":"Mirzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-6800","authenticated-orcid":false,"given":"SoJung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Arslanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Kuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.numecd.2026.104615_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjsem-2016-000143","article-title":"Update on the effects of physical activity on insulin sensitivity in humans","volume":"2","author":"Bird","year":"2017","journal-title":"BMJ Open Sport Exerc Med"},{"issue":"2","key":"10.1016\/j.numecd.2026.104615_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056415","article-title":"The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis","volume":"8","author":"Vissers","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2026.104615_bib3","article-title":"Physical activity and exercise within the context of obesity treatment: enhancing health beyond weight loss","author":"Jakicic","year":"2025","journal-title":"J Sport Health Sci"},{"issue":"5","key":"10.1016\/j.numecd.2026.104615_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/NNR.0b013e3182a0395c","article-title":"Meta-analysis of fitness outcomes from motivational physical activity interventions","volume":"62","author":"Chase","year":"2013","journal-title":"Nurs Res"},{"key":"10.1016\/j.numecd.2026.104615_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.mayocp.2022.09.011","article-title":"Physical activity and cardiorespiratory fitness as modulators of health outcomes: a compelling research-based case presented to the medical community","volume":"98","author":"Franklin","year":"2023","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"10.1016\/j.numecd.2026.104615_bib6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cmet.2023.12.025","article-title":"Understanding the variation in exercise responses to guide personalized physical activity prescriptions","volume":"36","author":"Noone","year":"2024","journal-title":"Cell Metab"},{"issue":"18","key":"10.1016\/j.numecd.2026.104615_bib7","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1136\/bjsports-2018-100328","article-title":"Precision exercise medicine: understanding exercise response variability","volume":"53","author":"Ross","year":"2019","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.numecd.2026.104615_bib8","doi-asserted-by":"crossref","first-page":"S446","DOI":"10.1097\/00005768-200106001-00013","article-title":"Individual differences in response to regular physical activity","volume":"33","author":"Bouchard","year":"2001","journal-title":"Med Sci Sports Exerc"},{"issue":"11","key":"10.1016\/j.numecd.2026.104615_bib10","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.2337\/db12-0214","article-title":"Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial","volume":"61","author":"Lee","year":"2012","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.numecd.2026.104615_bib11","doi-asserted-by":"crossref","first-page":"E1222","DOI":"10.1152\/ajpendo.00285.2013","article-title":"Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial","volume":"305","author":"Lee","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.numecd.2026.104615_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jpeds.2018.10.059","article-title":"Effects of exercise modality on insulin resistance and ectopic fat in adolescents with overweight and obesity: a randomized clinical trial","volume":"206","author":"Lee","year":"2019","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.numecd.2026.104615_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1753-4887.1981.tb06734.x","article-title":"Growth and maturation during adolescence","volume":"39","author":"Tanner","year":"1981","journal-title":"Nutr Rev"},{"issue":"246","key":"10.1016\/j.numecd.2026.104615_bib14","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","volume":"11","author":"Kuczmarski","year":"2002","journal-title":"Vital Health Stat"},{"issue":"1","key":"10.1016\/j.numecd.2026.104615_bib15","first-page":"66","article-title":"Glucose intolerance in Obese adolescents with polycystic ovary syndrome: roles of insulin resistance and \u03b2-Cell dysfunction and risk of cardiovascular Disease1","volume":"86","author":"Arslanian","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"18","key":"10.1016\/j.numecd.2026.104615_bib16","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJM199610313351804","article-title":"Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects","volume":"335","author":"Perseghin","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2026.104615_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/159373","article-title":"Whole-body MRI and ethnic differences in adipose tissue and skeletal muscle distribution in overweight black and white adolescent boys","volume":"2011","author":"Lee","year":"2011","journal-title":"J Obes"},{"issue":"6","key":"10.1016\/j.numecd.2026.104615_bib18","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1152\/jappl.1996.81.6.2445","article-title":"Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men","volume":"81","author":"Ross","year":"1985","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.numecd.2026.104615_bib19","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/ajcn\/80.5.1215","article-title":"Relation between whole-body and regional measures of human skeletal muscle","volume":"80","author":"Lee","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.numecd.2026.104615_bib20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1249\/MSS.0000000000001504","article-title":"Interindividual responses of appetite to acute exercise: a replicated crossover study","volume":"50","author":"Goltz","year":"2018","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.numecd.2026.104615_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnut.2018.00041","article-title":"A statistical framework to interpret individual response to intervention: paving the way for personalized nutrition and exercise prescription","volume":"5","author":"Swinton","year":"2018","journal-title":"Front Nutr"},{"issue":"3","key":"10.1016\/j.numecd.2026.104615_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/2150131913520328","article-title":"Insulin sensitivity following exercise interventions: systematic review and meta-analysis of outcomes among healthy adults","volume":"5","author":"Conn","year":"2014","journal-title":"J Prim Care Community Health"},{"issue":"3","key":"10.1016\/j.numecd.2026.104615_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13666","article-title":"Effects of various exercise types on visceral adipose tissue in individuals with overweight and obesity: a systematic review and network meta-analysis of 84 randomized controlled trials","volume":"25","author":"Chen","year":"2024","journal-title":"Obes Rev"},{"issue":"7","key":"10.1016\/j.numecd.2026.104615_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002014","article-title":"Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta\u2010analysis of randomized controlled trials","volume":"4","author":"Lin","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.numecd.2026.104615_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1139\/apnm-2019-0088","article-title":"Interindividual variability and individual responses to exercise training in adolescents with obesity","volume":"45","author":"Walsh","year":"2020","journal-title":"Appl Physiol Nutr Metabol"},{"issue":"3","key":"10.1016\/j.numecd.2026.104615_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1249\/MSS.0b013e3181896c4e","article-title":"Volume of exercise and fitness nonresponse in sedentary, postmenopausal women","volume":"41","author":"Sisson","year":"2009","journal-title":"Med Sci Sports Exerc"},{"issue":"11","key":"10.1016\/j.numecd.2026.104615_bib27","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.mayocp.2015.07.024","article-title":"Separate effects of intensity and amount of exercise on interindividual cardiorespiratory fitness response","volume":"90","author":"Ross","year":"2015","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"10.1016\/j.numecd.2026.104615_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1139\/apnm-2020-0707","article-title":"Interindividual variation in cardiometabolic health outcomes following 6 months of endurance training in youth at risk of type 2 diabetes mellitus","volume":"46","author":"Hrubeniuk","year":"2021","journal-title":"Appl Physiol Nutr Metabol"},{"key":"10.1016\/j.numecd.2026.104615_bib29","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/jamapediatrics.2014.1392","article-title":"Effects of aerobic training, resistance training, or both on percentage body fat and cardiometabolic risk markers in obese adolescents: the healthy eating aerobic and resistance training in youth randomized clinical trial","volume":"168","author":"Sigal","year":"2014","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.numecd.2026.104615_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4093\/dmj.2011.35.4.418","article-title":"Effects of resistance training and aerobic exercise on insulin sensitivity in overweight Korean adolescents: a controlled randomized trial","volume":"35","author":"Suh","year":"2011","journal-title":"Diabetes Metab J"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:07:01Z","timestamp":1790082421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475326000773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0939475326000773"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104615","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individual variability in insulin sensitivity, visceral fat, and cardiorespiratory fitness in response to exercise in adolescents with obesity","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104615"}}