{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:00:15Z","timestamp":1790085615654,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00040\/01"],"award-info":[{"award-number":["MC_UU_00040\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2025349"],"award-info":[{"award-number":["GNT2025349"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["225790\/Z\/22\/Z"],"award-info":[{"award-number":["225790\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.numecd.2026.104624","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:43:28Z","timestamp":1770741808000},"page":"104624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenome-wide study on alcohol consumption provides genetic evidence for a causal association with multiple diseases and biomarkers"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-0671","authenticated-orcid":false,"given":"Nigussie","family":"Assefa Kassaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Mulugeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Hypp\u04e7nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2026.104624_bib1","series-title":"Global status report on alcohol and health 2018","year":"2018"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib2","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/S2468-2667(19)30231-2","article-title":"National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use: a comparative risk assessment study","volume":"5","author":"Shield","year":"2020","journal-title":"Lancet Public Health"},{"issue":"10152","key":"10.1016\/j.numecd.2026.104624_bib3","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2026.104624_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.859947","article-title":"Alcohol and health outcomes: an umbrella review of meta-analyses base on prospective cohort studies","volume":"10","author":"Zhong","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.numecd.2026.104624_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d671","article-title":"Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis","volume":"342","author":"Ronksley","year":"2011","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12916-021-02040-2","article-title":"Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women","volume":"19","author":"Ding","year":"2021","journal-title":"BMC Med"},{"key":"10.1016\/j.numecd.2026.104624_bib8","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for Clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.numecd.2026.104624_bib9","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"issue":"R1","key":"10.1016\/j.numecd.2026.104624_bib10","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/imm.12195","article-title":"The challenges, advantages and future of phenome-wide association studies","volume":"141","author":"Hebbring","year":"2014","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.numecd.2026.104624_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/bioinformatics\/btq126","article-title":"PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene\u2013disease associations","volume":"26","author":"Denny","year":"2010","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jama.2021.20356","article-title":"Phenome-wide association studies","volume":"327","author":"Bastarache","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.numecd.2026.104624_bib14","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/S2589-7500(19)30028-7","article-title":"A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK biobank","volume":"1","author":"Hypp\u00f6nen","year":"2019","journal-title":"Lancet Digit Health"},{"issue":"10183","key":"10.1016\/j.numecd.2026.104624_bib15","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(18)31772-0","article-title":"Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China","volume":"393","author":"Millwood","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.numecd.2026.104624_bib16","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/ijc.33917","article-title":"Alcohol metabolism genes and risks of site-specific cancers in Chinese adults: an 11-year prospective study","volume":"150","author":"Im","year":"2022","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib17","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/s41467-024-46927-z","article-title":"Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers","volume":"15","author":"Went","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.numecd.2026.104624_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105086","article-title":"A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals","volume":"103","author":"Jennings","year":"2024","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.numecd.2026.104624_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyae046","article-title":"Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study","volume":"53","author":"Kassaw","year":"2024","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.numecd.2026.104624_bib21","series-title":"Alcohol guidelines review\u2013report from the guidelines development group to the UK chief medical officers","year":"2016"},{"issue":"7","key":"10.1016\/j.numecd.2026.104624_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175508","article-title":"Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record","volume":"12","author":"Wei","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2026.104624_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100488","article-title":"Mendelian randomization case-control PheWAS in UK biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions","volume":"26","author":"King","year":"2020","journal-title":"eClinicalMedicine"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12859-018-2135-0","article-title":"A simulation study investigating power estimates in phenome-wide association studies","volume":"19","author":"Verma","year":"2018","journal-title":"BMC Bioinf"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use","volume":"51","author":"Liu","year":"2019","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Stat Soc B"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"4","key":"10.1016\/j.numecd.2026.104624_bib28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1016\/j.numecd.2026.104624_bib29","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.numecd.2026.104624_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.numecd.2026.104624_bib31","first-page":"1866","article-title":"Triangulation in aetiological epidemiology","volume":"45","author":"Lawlor","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"6","key":"10.1016\/j.numecd.2026.104624_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010823","article-title":"Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method","volume":"19","author":"Tian","year":"2023","journal-title":"PLoS Genet"},{"key":"10.1016\/j.numecd.2026.104624_bib33","doi-asserted-by":"crossref","DOI":"10.1007\/s10654-024-01121-9","article-title":"Towards more reliable non-linear mendelian randomization investigations","author":"Burgess","year":"2024","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2026.104624_bib34","doi-asserted-by":"crossref","DOI":"10.1007\/s10654-025-01208-x","article-title":"Non-linear Mendelian randomization: evaluation of effect modification in the residual and doubly-ranked methods with simulated and empirical examples","author":"Hamilton","year":"2025","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"10.1016\/j.numecd.2026.104624_bib35","first-page":"162","article-title":"An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the national epidemiologic survey on alcohol and related conditions","volume":"29","author":"Falk","year":"2006","journal-title":"Alcohol Res Health"},{"issue":"7","key":"10.1016\/j.numecd.2026.104624_bib36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/ajem.2002.35464","article-title":"Altered mental status: evaluation and etiology in the ED","volume":"20","author":"Kanich","year":"2002","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.numecd.2026.104624_bib37","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jad.2022.07.008","article-title":"Modifiable risk factors for incident dementia and cognitive impairment: an umbrella review of evidence","volume":"314","author":"Zhang","year":"2022","journal-title":"J Affect Disord"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib38","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1097\/j.pain.0000000000002360","article-title":"Alcohol, coffee consumption, and smoking in relation to migraine: a bidirectional Mendelian randomization study","volume":"163","author":"Yuan","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.numecd.2026.104624_bib39","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2741\/1857","article-title":"Alcohol intoxication and post-burn complications","volume":"11","author":"Choudhry","year":"2006","journal-title":"Front Biosci"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib40","doi-asserted-by":"crossref","DOI":"10.1097\/TA.0b013e318158a4ad","article-title":"Alcohol-induced alterations on host defense after traumatic injury","volume":"64","author":"Greiffenstein","year":"2008","journal-title":"J Trauma Acute Care Surg"},{"issue":"8","key":"10.1016\/j.numecd.2026.104624_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255801","article-title":"Alcohol use and cardiometabolic risk in the UK biobank: a Mendelian randomization study","volume":"16","author":"Lankester","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.numecd.2026.104624_bib42","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002814","article-title":"Alcohol consumption and cardiovascular disease: a mendelian randomization study","volume":"13","author":"Larsson","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"3","key":"10.1016\/j.numecd.2026.104624_bib43","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.3849","article-title":"Association of habitual alcohol intake with risk of cardiovascular disease","volume":"5","author":"Biddinger","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"12","key":"10.1016\/j.numecd.2026.104624_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003410","article-title":"Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: a multivariable Mendelian randomization study","volume":"17","author":"Rosoff","year":"2020","journal-title":"PLoS Med"},{"issue":"5","key":"10.1016\/j.numecd.2026.104624_bib45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4330\/wjc.v6.i5.245","article-title":"Alcohol-induced hypertension: mechanism and prevention","volume":"6","author":"Husain","year":"2014","journal-title":"World J Cardiol"},{"issue":"19","key":"10.1016\/j.numecd.2026.104624_bib46","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1161\/01.CIR.102.19.2347","article-title":"Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II","volume":"102","author":"De Oliveira e Silva","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib47","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.numecd.2026.104624_bib48","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84051","article-title":"Smoking, alcohol consumption, and 24 gastrointestinal diseases: mendelian randomization analysis","volume":"12","author":"Yuan","year":"2023","journal-title":"eLife"},{"issue":"10","key":"10.1016\/j.numecd.2026.104624_bib49","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.14309\/ajg.0000000000000340","article-title":"Alcohol consumption and risk of liver cirrhosis: a systematic review and meta-analysis","volume":"114","author":"Roerecke","year":"2019","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/0976-9668.149091","article-title":"Clinicopathological study and management of liver abscess in a tertiary care center","volume":"6","author":"Jha","year":"2015","journal-title":"J Nat Sci Biol Med"},{"issue":"4","key":"10.1016\/j.numecd.2026.104624_bib51","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.5455\/2320-6012.ijrms20141113","article-title":"Role of alcoholism in liver abscess","volume":"2","author":"Raja","year":"2017","journal-title":"International Journal of Research in Medical Sciences"},{"issue":"21","key":"10.1016\/j.numecd.2026.104624_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214529","article-title":"Alcohol drinking patterns and laboratory indices of health: does type of alcohol preferred make a difference?","volume":"14","author":"Niemel\u00e4","year":"2022","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.numecd.2026.104624_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188574","article-title":"Where should the safe limits of alcohol consumption stand in light of liver enzyme abnormalities in alcohol consumers?","volume":"12","author":"Niemel\u00e4","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib54","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12937-016-0180-y","article-title":"Assessing alcohol intake & its dose-dependent effects on liver enzymes by 24-h recall and questionnaire using NHANES 2001-2010 data","volume":"15","author":"Agarwal","year":"2016","journal-title":"Nutr J"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.35946\/arcr.v38.2.08","article-title":"Pathophysiology of the effects of alcohol abuse on the endocrine system","volume":"38","author":"Rachdaoui","year":"2017","journal-title":"Alcohol Res"},{"key":"10.1016\/j.numecd.2026.104624_bib56","series-title":"Electrolytes. In: StatPearls [Internet]. Treasure island (FL): Statpearls publishing copyright \u00a9 2023","author":"Shrimanker","year":"2023"},{"issue":"5","key":"10.1016\/j.numecd.2026.104624_bib57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/003655101316911459","article-title":"Moderate alcohol consumption and urinary excretion of magnesium and calcium","volume":"61","author":"Rylander","year":"2001","journal-title":"Scand J Clin Lab Invest"},{"issue":"6","key":"10.1016\/j.numecd.2026.104624_bib58","article-title":"Magnesium, calcium, potassium, sodium, Phosphorus, selenium, zinc, and chromium levels in alcohol use disorder: a review","volume":"9","author":"Baj","year":"2020","journal-title":"Journal of Clinical Medicine [Internet]"},{"issue":"2","key":"10.1016\/j.numecd.2026.104624_bib59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/0300-1652.129631","article-title":"Kidney injury, fluid, electrolyte and acid-base abnormalities in alcoholics","volume":"55","author":"Adewale","year":"2014","journal-title":"Niger Med J"},{"issue":"27","key":"10.1016\/j.numecd.2026.104624_bib60","article-title":"Self-fluid management in prevention of kidney stones: a PRISMA-Compliant systematic review and dose-response meta-analysis of observational studies","volume":"94","author":"Xu","year":"2015","journal-title":"Medicine (United States)"},{"issue":"4","key":"10.1016\/j.numecd.2026.104624_bib61","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.euf.2019.05.002","article-title":"Fluid intake and dietary factors and the risk of incident kidney stones in UK biobank: a population-based prospective cohort study","volume":"6","author":"Littlejohns","year":"2020","journal-title":"European Urology Focus"},{"key":"10.1016\/j.numecd.2026.104624_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1268720","article-title":"The causal association between smoking, alcohol consumption and risk of upper urinary calculi: insights from a Mendelian randomization study","volume":"14","author":"Wang","year":"2023","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.numecd.2026.104624_bib63","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/s41598-021-81777-5","article-title":"Effect of alcohol consumption on kidney function: population-based cohort study","volume":"11","author":"Lee","year":"2021","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.numecd.2026.104624_bib64","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10654-024-01113-9","article-title":"Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, vitamin D and LDL cholesterol","volume":"39","author":"Hamilton","year":"2024","journal-title":"Eur J Epidemiol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326000864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:05:57Z","timestamp":1790082357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475326000864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0939475326000864"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104624","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenome-wide study on alcohol consumption provides genetic evidence for a causal association with multiple diseases and biomarkers","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.","name":"copyright","label":"Copyright"}],"article-number":"104624"}}