{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:13:09Z","timestamp":1788592389523,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100020207","name":"Sichuan Province Health Commission","doi-asserted-by":"publisher","award":["23LCYJ045"],"award-info":[{"award-number":["23LCYJ045"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFFK0284"],"award-info":[{"award-number":["2024YFFK0284"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.numecd.2026.104773","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:42:13Z","timestamp":1777131733000},"page":"104773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Residual cardiovascular risk factors and incident myocardial infarction in individuals with low levels of baseline low-density lipoprotein cholesterol: a cohort study"],"prefix":"10.1016","volume":"36","author":[{"given":"Chi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-888X","authenticated-orcid":false,"given":"Long","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2026.104773_bib1","first-page":"e41","article-title":"Heart disease and stroke statistics: a report of US and global data from the American heart association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2026.104773_bib2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIR.0b013e3182285a81","article-title":"Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American heart association","volume":"124","author":"Weintraub","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2026.104773_bib3","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.jacc.2018.11.002","article-title":"AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: executive summary: a report of the American college of cardiology\/american heart association task force on clinical practice guidelines","volume":"73","author":"Grundy","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2026.104773_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2026.104773_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/clinchem\/hvaa252","article-title":"Residual cardiovascular risk at low LDL: remnants, lipoprotein(a), and inflammation","volume":"67","author":"Hoogeveen","year":"2021","journal-title":"Clin Chem"},{"key":"10.1016\/j.numecd.2026.104773_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11883-011-0219-7","article-title":"Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges","volume":"14","author":"Sampson","year":"2012","journal-title":"CURR ATHEROSCLER REP"},{"key":"10.1016\/j.numecd.2026.104773_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tcm.2021.04.002","article-title":"Coronary heart disease risk: low-density lipoprotein and beyond","volume":"32","author":"Shaya","year":"2022","journal-title":"TRENDS CARDIOVAS MED"},{"key":"10.1016\/j.numecd.2026.104773_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12967-022-03448-x","article-title":"Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome","volume":"20","author":"Liu","year":"2022","journal-title":"J Transl Med"},{"key":"10.1016\/j.numecd.2026.104773_bib9","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1093\/eurheartj\/ehab705","article-title":"Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study","volume":"43","author":"Wadstr\u00f6m","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2026.104773_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2023.03.012","article-title":"Association of remnant cholesterol with risk of cardiovascular disease events, stroke, and mortality: a systemic review and meta-analysis","volume":"371","author":"Yang","year":"2023","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2026.104773_bib11","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1161\/ATVBAHA.123.319297","article-title":"Independent causal effect of remnant cholesterol on atherosclerotic cardiovascular outcomes: a mendelian randomization study","volume":"43","author":"Navarese","year":"2023","journal-title":"ARTERIOSCL THROM VAS"},{"key":"10.1016\/j.numecd.2026.104773_bib12","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically elevated lipoprotein(a) and increased risk of myocardial infarction","volume":"301","author":"Kamstrup","year":"2009","journal-title":"JAMA, J Am Med Assoc"},{"key":"10.1016\/j.numecd.2026.104773_bib13","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.jacc.2025.02.032","article-title":"Prevalence of elevated lipoprotein(a) and its association with subclinical atherosclerosis in 2.9 million Chinese adults","volume":"85","author":"Man","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2026.104773_bib14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"NEW ENGL J MED"},{"key":"10.1016\/j.numecd.2026.104773_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/CIRCULATIONAHA.118.034032","article-title":"Inflammatory and cholesterol risk in the FOURIER trial","volume":"138","author":"Bohula","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2026.104773_bib16","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/jamacardio.2022.0987","article-title":"Lipoprotein(a) and its significance in cardiovascular disease: a review","volume":"7","author":"Duarte","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.numecd.2026.104773_bib17","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCULATIONAHA.113.003008","article-title":"Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation","volume":"128","author":"Varbo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2026.104773_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2026.104773_bib19","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1016\/S2468-2667(24)00028-8","article-title":"Socioeconomic inequalities in accumulation of multimorbidity in England from 2019 to 2049: a microsimulation projection study","volume":"9","author":"Head","year":"2024","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.numecd.2026.104773_bib20","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/dom.16132","article-title":"The predictive value of estimated glucose disposal rate and its association with myocardial infarction, heart failure, atrial fibrillation and ischemic stroke","volume":"27","author":"Huang","year":"2025","journal-title":"DIABETES OBES METAB"},{"key":"10.1016\/j.numecd.2026.104773_bib21","first-page":"1498","article-title":"Association of triglyceride-glucose index and its combination with adiposity-related indices with the incidence of myocardial infarction: a cohort study from the UK biobank","volume":"48","author":"Zhou","year":"2024","journal-title":"INT J OBESITY"},{"key":"10.1016\/j.numecd.2026.104773_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ije\/dym276","article-title":"The UK biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine","volume":"37","author":"Elliott","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.numecd.2026.104773_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/j.ajkd.2021.08.003","article-title":"A unifying approach for GFR estimation: recommendations of the NKF-ASN task force on reassessing the inclusion of race in diagnosing kidney disease","volume":"79","author":"Delgado","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.numecd.2026.104773_bib24","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1016\/j.jacc.2020.10.008","article-title":"Remnant cholesterol, not LDL cholesterol, is associated with incident cardiovascular disease","volume":"76","author":"Casta\u00f1er","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2026.104773_bib25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12933-022-01667-6","article-title":"Remnant cholesterol and the risk of cardiovascular disease in type 2 diabetes: a nationwide longitudinal cohort study","volume":"21","author":"Huh","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.numecd.2026.104773_bib26","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1007\/s00125-023-06016-0","article-title":"Elevated remnant cholesterol and atherosclerotic cardiovascular disease in diabetes: a population-based prospective cohort study","volume":"66","author":"Wadstr\u00f6m","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2026.104773_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.atherosclerosis.2021.11.018","article-title":"Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population","volume":"349","author":"Loh","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2026.104773_bib28","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1161\/CIRCULATIONAHA.118.034311","article-title":"Lipoprotein(a) levels and the risk of myocardial infarction among 7 ethnic groups","volume":"139","author":"Par\u00e9","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2026.104773_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/eurheartj\/ehaa099","article-title":"Targeting cardiovascular inflammation: next steps in clinical translation","volume":"42","author":"Lawler","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2026.104773_bib30","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"NEW ENGL J MED"},{"key":"10.1016\/j.numecd.2026.104773_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105786","article-title":"The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20 years","volume":"117","author":"Hartley","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.numecd.2026.104773_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"LANCET (N AM ED)"},{"key":"10.1016\/j.numecd.2026.104773_bib33","article-title":"Combined effect of D-dimer, hs-CRP, and Lp(a) on 5-year clinical outcomes after percutaneous coronary intervention: a large real-world study in China","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.numecd.2026.104773_bib34","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1056\/NEJMoa2405182","article-title":"Inflammation, cholesterol, lipoprotein(a), and 30-Year cardiovascular outcomes in women","volume":"391","author":"Ridker","year":"2024","journal-title":"NEW ENGL J MED"},{"key":"10.1016\/j.numecd.2026.104773_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehaf209","article-title":"Low-density lipoprotein cholesterol, C-reactive protein, and lipoprotein(a) universal one-time screening in primary prevention: the EPIC-norfolk study","author":"Kraaijenhof","year":"2025","journal-title":"Eur Heart J"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326002358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475326002358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:02:38Z","timestamp":1788591758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475326002358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0939475326002358"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104773","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Residual cardiovascular risk factors and incident myocardial infarction in individuals with low levels of baseline low-density lipoprotein cholesterol: a cohort study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2026.104773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104773"}}