{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:23:38Z","timestamp":1792193018643,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":5977,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.nurt.2007.01.014","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T07:19:14Z","timestamp":1175066354000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":163,"title":["Episodic Ataxia Type 2"],"prefix":"10.1016","volume":"4","author":[{"given":"Michael","family":"Strupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zwergal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nurt.2007.01.014_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng1094-136","article-title":"Episodic ataxia\/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1","volume":"8","author":"Browne","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib2","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1523\/JNEUROSCI.22-12-04786.2002","article-title":"Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKv\u03b21-induced N-type inactivation","volume":"22","author":"Maylie","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2007.01.014_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/mds.870060218","article-title":"Hereditary paroxysmal ataxia with neuromyotonia","volume":"6","author":"Vaamonde","year":"1991","journal-title":"Mov Disord"},{"key":"10.1016\/j.nurt.2007.01.014_bib4","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1212\/WNL.57.8.1499","article-title":"An autosomal dominant disorder with episodic ataxia, vertigo, and tinnitus","volume":"57","author":"Steckley","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archneur.1963.00460050021002","article-title":"Vestibulocerebellar ataxia: a newly defined hereditary syndrome with periodic manifestations","volume":"8","author":"Farmer","year":"1963","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib6","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1086\/302909","article-title":"Coding and noncoding variation of the human calcium-channel \u03b24-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia","volume":"66","author":"Escayg","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000172638.58172.5a","article-title":"Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures","volume":"65","author":"Jen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/geno.1996.0013","article-title":"A gene for autosomal dominant paroxysmal choreoathetosis\/spasticity (CSE) maps to the vicinity of a potassium channel gene cluster on chromosome 1p, probably within 2 cM between D1S443 and D1S197","volume":"31","author":"Auburger","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.nurt.2007.01.014_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.410370302","article-title":"Episodic ataxias as channelopathies","volume":"37","author":"Griggs","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","article-title":"Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4","volume":"87","author":"Ophoff","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nurt.2007.01.014_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000259262","article-title":"Episodic ataxia type 1 and 2 (familial periodic ataxia\/vertigo)","volume":"2","author":"Brandt","year":"1997","journal-title":"Audiol Neurootol"},{"key":"10.1016\/j.nurt.2007.01.014_bib12","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1212\/01.wnl.0000176069.64200.28","article-title":"Late-onset episodic ataxia type 2 due to an in-frame insertion in CACNA1A","volume":"65","author":"Imbrici","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/mds.870010404","article-title":"Autosomal dominant episodic ataxia: a heterogeneous syndrome","volume":"1","author":"Gancher","year":"1986","journal-title":"Mov Disord"},{"key":"10.1016\/j.nurt.2007.01.014_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1212\/01.WNL.0000101675.61074.50","article-title":"Clinical spectrum of episodic ataxia type 2","volume":"62","author":"Jen","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1743-5013.2006.00027.x","article-title":"Migraine and vertigo: Classification, clinical features and special treatment considerations","volume":"3","author":"Brandt","year":"2006","journal-title":"Headache Currents"},{"key":"10.1016\/j.nurt.2007.01.014_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.1294","article-title":"Familial benign recurrent vertigo","volume":"100","author":"Oh","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ncl.2005.01.003","article-title":"Migrainous vertigo","volume":"23","author":"Lempert","year":"2005","journal-title":"Neurol Clin"},{"key":"10.1016\/j.nurt.2007.01.014_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00415-003-0994-3","article-title":"Neurotological findings in a family with episodic ataxia","volume":"250","author":"Sasaki","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1196\/annals.1325.070","article-title":"Internuclear ophthalmoparesis in episodic ataxia type 2","volume":"1039","author":"Rucker","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.nurt.2007.01.014_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00401-004-0899-y","article-title":"Hereditary paroxysmal ataxia with mental retardation: a clinicopathological study in relation to episodic ataxia type 2","volume":"108","author":"Mochizuki","year":"2004","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.nurt.2007.01.014_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/archneur.62.2.314","article-title":"Two novel CACNA1A gene mutations associated with episodic ataxia type 2 and interictal dystonia","volume":"62","author":"Spacey","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0987-7053(97)85101-5","article-title":"EEG findings in acetazolamide-responsive hereditary paroxysmal ataxia","volume":"26","author":"Van Bogaert","year":"1996","journal-title":"Neurophysiol Clin"},{"key":"10.1016\/j.nurt.2007.01.014_bib23","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1093\/brain\/awh301","article-title":"Dysfunction of the brain calcium channel Cav2.1 in absence epilepsy and episodic ataxia","volume":"127","author":"Imbrici","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2007.01.014_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1001\/archneur.1988.00520290083018","article-title":"Magnetic resonance imaging in familial paroxysmal ataxia","volume":"45","author":"Vighetto","year":"1988","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/jnnp.55.3.212","article-title":"Familial paroxysmal ataxia: report of a family","volume":"55","author":"Hawkes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nurt.2007.01.014_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.410310205","article-title":"Familial periodic cerebellar ataxia: a problem of cerebellar intracellular pH homeostasis","volume":"31","author":"Bain","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/01.WNL.0000150589.26350.3D","article-title":"Decreased cerebellar total creatine in episodic ataxia type 2: a 1H MRS study","volume":"64","author":"Harno","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ana.410370304","article-title":"A gene for hereditary paroxysmal cerebellar ataxia maps to chromosome 19p","volume":"37","author":"Vahedi","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/hmg\/4.2.279","article-title":"Mapping the gene for acetazolamide responsive hereditary paryoxysmal cerebellar ataxia to chromosome 19p","volume":"4","author":"von Brederlow","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib30","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/S0024-3205(01)01042-6","article-title":"Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons","volume":"68","author":"Shapiro","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.nurt.2007.01.014_bib31","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1212\/01.wnl.0000169020.82223.dd","article-title":"New calcium channel mutations predict aberrant RNA splicing in episodic ataxia","volume":"65","author":"Eunson","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib32","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1212\/01.WNL.0000167409.59089.C0","article-title":"CACNA1A mutations causing episodic and progressive ataxia alter channel trafficking and kinetics","volume":"64","author":"Wan","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1086\/318804","article-title":"Complete loss of P\/Q calcium channel activity caused by a CACNA1A missense mutation carried by patients with episodic ataxia type 2","volume":"68","author":"Guida","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib34","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1074\/jbc.M110948200","article-title":"Functional consequences of P\/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia","volume":"277","author":"Wappl","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2007.01.014_bib35","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/hmg\/6.11.1973","article-title":"Episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) due to CAG repeat expansion in the CACNA1A gene on chromosome 19p","volume":"6","author":"Jodice","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib36","doi-asserted-by":"crossref","first-page":"13284","DOI":"10.1073\/pnas.192242399","article-title":"Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons","volume":"99","author":"Tottene","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2007.01.014_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0197-62","article-title":"Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the \u03b11A-voltage-dependent calcium channel","volume":"15","author":"Zhuchenko","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.nurt.2007.01.014_bib38","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/01.WNL.0000099748.41130.9A","article-title":"Presynaptic failure of neuromuscular transmission and synaptic remodeling in EA2","volume":"61","author":"Maselli","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1648","article-title":"Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia","volume":"9","author":"Walter","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.nurt.2007.01.014_bib40","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1212\/01.WNL.0000125691.74109.53","article-title":"Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine","volume":"62","author":"Strupp","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib41","first-page":"187","article-title":"A family of episodic ataxia type 2: no evidence of genetic linkage to the CACNA1A gene","volume":"11","author":"Hirose","year":"2003","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nurt.2007.01.014_bib42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1212\/01.wnl.0000167186.05465.7c","article-title":"A genome-wide screen and linkage mapping for a large pedigree with episodic ataxia","volume":"65","author":"Cader","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib43","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fasebj.13.11.1335","article-title":"Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K+ channel function","volume":"13","author":"D\u2019Adamo","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.nurt.2007.01.014_bib44","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/1531-8249(199908)46:2<256::AID-ANA17>3.0.CO;2-6","article-title":"Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2","volume":"46","author":"Sappey-Marinier","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib45","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0092-8674(00)81381-1","article-title":"Absence epilepsy in tottering mutant mice is associated with calcium channel defects","volume":"87","author":"Fletcher","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nurt.2007.01.014_bib46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.nbd.2005.03.004","article-title":"Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy","volume":"20","author":"Fureman","year":"2005","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nurt.2007.01.014_bib47","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1523\/JNEUROSCI.0098-05.2005","article-title":"Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering","volume":"25","author":"Weisz","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2007.01.014_bib48","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1523\/JNEUROSCI.18-12-04482.1998","article-title":"Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner","volume":"18","author":"Lorenzon","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2007.01.014_bib49","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1523\/JNEUROSCI.20-15-05654.2000","article-title":"Reduced voltage sensitivity of activation of P\/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tgrol)","volume":"20","author":"Mori","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2007.01.014_bib50","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/brain\/120.5.805","article-title":"Acetazolamide-responsive episodic ataxia in an Italian family refines gene mapping on chromosome 19p13","volume":"120","author":"Calandriello","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2007.01.014_bib51","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1212\/WNL.28.12.1259","article-title":"Hereditary paroxysmal ataxia: response to acetazolamide","volume":"28","author":"Griggs","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib52","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00415-004-0299-1","article-title":"Acetazolamide improves neurotological abnormalities in a family with episodic ataxia type 2 (EA-2)","volume":"251","author":"Harno","year":"2004","journal-title":"J Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7326\/0003-4819-73-1-39","article-title":"Acetazolamide treatment of hypokalemic periodic paralysis: prevention of attacks and improvement of persistent weakness","volume":"73","author":"Griggs","year":"1970","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nurt.2007.01.014_bib54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/archneur.1975.00490480051006","article-title":"Acetazolamide treatment of hypokalemic periodic paralysis: probable mechanism of action","volume":"32","author":"Vroom","year":"1975","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1600-0404.1977.tb01458.x","article-title":"Effect upon serum insulin, glucose and potassium concentrations of acetazolamide during attacks of familial periodic hypokalemic paralysis","volume":"56","author":"Johnsen","year":"1977","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.nurt.2007.01.014_bib56","first-page":"655","article-title":"Periodic familial paralysis with hypokalemia: hemodynamic and metabolic studies: favorable effect of acetazolamide","volume":"134","author":"Goulon","year":"1978","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.nurt.2007.01.014_bib57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/archneur.1979.00500450062011","article-title":"Familial periodic ataxia","volume":"36","author":"Donat","year":"1979","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib58","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1212\/WNL.33.9.1212","article-title":"Acetazolamide-responsive episodic ataxia syndrome","volume":"33","author":"Zasorin","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib59","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/brain\/awf071","article-title":"Enhanced inactivation and pH sensitivity of Na+ channel mutations causing hypokalaemic periodic paralysis type II","volume":"125","author":"Kuzmenkin","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2007.01.014_bib60","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1085\/jgp.61.6.687","article-title":"Ionic blockage of sodium channels in nerve","volume":"61","author":"Woodhull","year":"1973","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.nurt.2007.01.014_bib61","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ana.20169","article-title":"Functional implications of a novel EA2 mutation in the P\/Q-type calcium channel","volume":"56","author":"Spacey","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib62","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/113.5.1361","article-title":"Familial paroxysmal kinesigenic ataxia and continuous myokymia","volume":"113","author":"Brunt","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2007.01.014_bib63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1017\/S0317167100004728","article-title":"CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid","volume":"33","author":"Scoggan","year":"2006","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.nurt.2007.01.014_bib64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1212\/01.WNL.0000078893.41040.56","article-title":"Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study","volume":"61","author":"Strupp","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2007.01.014_bib65","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s002210100788","article-title":"Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells","volume":"139","author":"Etzion","year":"2001","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.nurt.2007.01.014_bib66","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(02)00071-6","article-title":"Neurological disorders caused by inherited ion-channel mutations","volume":"1","author":"Kullmann","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nurt.2007.01.014_bib67","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.nurt.2007.01.003","article-title":"Molecular pathogenesis of spinocerbellar ataxia type 6","volume":"4","author":"Kordasiewicz","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nurt.2007.01.014_bib68","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nurt.2007.01.010","article-title":"Episodic ataxia type 1: A neuronal potassium channelopathy","volume":"4","author":"Rajakulendran","year":"2007","journal-title":"Neurotherapeutics"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923006694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923006694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1016\/j.nurt.2007.01.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:38:35Z","timestamp":1761806315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923006694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S1878747923006694"],"URL":"https:\/\/doi.org\/10.1016\/j.nurt.2007.01.014","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Episodic Ataxia Type 2","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nurt.2007.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}