{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:10:46Z","timestamp":1791220246916,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":5520,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.nurt.2008.05.010","type":"journal-article","created":{"date-parts":[[2008,7,13]],"date-time":"2008-07-13T04:34:29Z","timestamp":1215923669000},"page":"391-398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"title":["Inhibition and Modulation of \u03b3-Secretase for Alzheimer's Disease"],"prefix":"10.1016","volume":"5","author":[{"given":"Michael S.","family":"Wolfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nurt.2008.05.010_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/1565","article-title":"Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau","volume":"1","author":"Hardy","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.nurt.2008.05.010_bib2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.nurt.2008.05.010_bib3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nurt.2008.05.010_bib4","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","article-title":"The carboxy terminus of the \u03b2 amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease","volume":"32","author":"Jarrett","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.nurt.2008.05.010_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(94)90458-8","article-title":"Visualization of A\u03b242(43) and A\u03b240 in senile plaques with end-specific A\u03b2 monoclonals: evidence that an initially deposited species is A\u03b242(43)","volume":"13","author":"Iwatsubo","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.nurt.2008.05.010_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nurt.2008.05.010_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.nurt.2008.05.010_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","article-title":"Secreted amyloid \u03b2-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.nurt.2008.05.010_bib11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/383710a0","article-title":"Increased amyloid-\u03b242(43) in brains of mice expressing mutant presenilin 1","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib12","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nm1096-1146","article-title":"The E280A presenilin 1 Alzheimer mutation produces increased A\u03b242 deposition and severe cerebellar pathology","volume":"2","author":"Lemere","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.nurt.2008.05.010_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm0197-67","article-title":"Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid \u03b2-protein in both transfected cells and transgenic mice","volume":"3","author":"Citron","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.nurt.2008.05.010_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80291-3","article-title":"Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo","volume":"17","author":"Thinakaran","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.nurt.2008.05.010_bib15","doi-asserted-by":"crossref","first-page":"24536","DOI":"10.1074\/jbc.272.39.24536","article-title":"Endoproteolytic processing and stabilization of wild-type and mutant presenilin","volume":"272","author":"Ratovitski","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib16","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1074\/jbc.273.6.3205","article-title":"The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100\u201350-kDa molecular mass complex","volume":"273","author":"Capell","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","article-title":"Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/35017105","article-title":"Total inactivation of \u03b3-secretase activity in presenilin-deficient embryonic stem cells","volume":"2","author":"Herreman","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.nurt.2008.05.010_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/35017108","article-title":"Presenilins are required for \u03b3-secretase cleavage of \u03b2-APP and transmembrane cleavage of Notch-1","volume":"2","author":"Zhang","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.nurt.2008.05.010_bib20","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1021\/bi982562p","article-title":"Peptidomimetic probes and molecular modeling suggest Alzheimer's \u03b3-secretases are intramembrane-cleaving aspartyl proteases","volume":"38","author":"Wolfe","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.nurt.2008.05.010_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","article-title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and \u03b3-secretase activity","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib22","doi-asserted-by":"crossref","first-page":"11223","DOI":"10.1021\/bi991080q","article-title":"Are presenilins intramembrane-cleaving proteases?","volume":"38","author":"Wolfe","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.nurt.2008.05.010_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/35015085","article-title":"Photoactivated \u03b3-secretase inhibitors directed to the active site covalently label presenilin 1","volume":"405","author":"Li","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/35017062","article-title":"Transition-state analogue inhibitors of \u03b3-secretase bind directly to presenilin-1","volume":"2","author":"Esler","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.nurt.2008.05.010_bib25","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1073\/pnas.052436599","article-title":"Activity-dependent isolation of the presenilin\/\u03b3-secretase complex reveals nicastrin and a \u03b3 substrate","volume":"99","author":"Esler","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib26","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.1037392100","article-title":"\u03b3-Secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2","volume":"100","author":"Kimberly","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/35024009","article-title":"Nicastrin modulates presenilin-mediated notch\/glp-1 signal transduction and \u03b2APP processing","volume":"407","author":"Yu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.022523499","article-title":"APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos","volume":"99","author":"Goutte","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","article-title":"Aph-1 and Pen-2 are required for Notch pathway signaling, \u03b3-secretase cleavage of \u03b2APP, and presenilin protein accumulation","volume":"3","author":"Francis","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.nurt.2008.05.010_bib30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","article-title":"The role of presenilin cofactors in the \u03b3-secretase complex","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ncb960","article-title":"Reconstitution of \u03b3-secretase activity","volume":"5","author":"Edbauer","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.nurt.2008.05.010_bib32","doi-asserted-by":"crossref","first-page":"9774","DOI":"10.1021\/bi0494976","article-title":"Purification and characterization of the human \u03b3-secretase complex","volume":"43","author":"Fraering","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.nurt.2008.05.010_bib33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2005.05.022","article-title":"Nicastrin functions as a \u03b3-secretase-substrate receptor","volume":"122","author":"Shah","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nurt.2008.05.010_bib34","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1073\/pnas.0502768102","article-title":"CD147 is a regulatory subunit of the \u03b3-secretase complex in Alzheimer's disease amyloid \u03b2-peptide production","volume":"102","author":"Zhou","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib35","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1126\/science.1070925","article-title":"Identification of signal peptide peptidase, a presenilin-type aspartic protease","volume":"296","author":"Weihofen","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nurt.2008.05.010_bib36","doi-asserted-by":"crossref","first-page":"37213","DOI":"10.1074\/jbc.M303941200","article-title":"Assembly of the \u03b3-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin","volume":"278","author":"LaVoie","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib37","doi-asserted-by":"crossref","first-page":"43284","DOI":"10.1074\/jbc.M305685200","article-title":"The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the \u03b3-secretase complex","volume":"278","author":"Morais","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib38","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1471-4159.2004.02447.x","article-title":"Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1","volume":"89","author":"Shirotani","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2008.05.010_bib39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.200304014","article-title":"Different cofactor activities in \u03b3-secretase assembly: evidence for a nicastrin\u2013Aph-1 subcomplex","volume":"161","author":"Hu","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nurt.2008.05.010_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1021\/bi035748j","article-title":"Detergent-dependent dissociation of active \u03b3-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex","volume":"43","author":"Fraering","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.nurt.2008.05.010_bib41","doi-asserted-by":"crossref","first-page":"41967","DOI":"10.1074\/jbc.M509066200","article-title":"Pen-2 is incorporated into the \u03b3-secretase complex through binding to transmembrane domain 4 of presenilin 1","volume":"280","author":"Watanabe","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib42","doi-asserted-by":"crossref","first-page":"41953","DOI":"10.1074\/jbc.M509070200","article-title":"Evidence that the \u201cNF\u201d motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2","volume":"280","author":"Kim","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib43","doi-asserted-by":"crossref","first-page":"11794","DOI":"10.1021\/ja037131v","article-title":"Designed helical peptides inhibit an intramembrane protease","volume":"125","author":"Das","year":"2003","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.nurt.2008.05.010_bib44","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1021\/jm049788c","article-title":"Discovery of a subnanomolar helical d-tridecapeptide inhibitor of \u03b3-secretase","volume":"47","author":"Bihel","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib45","doi-asserted-by":"crossref","first-page":"16470","DOI":"10.1074\/jbc.C300019200","article-title":"Differential effects of inhibitors on the \u03b3-secretase complex: mechanistic implications","volume":"278","author":"Kornilova","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib46","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1073\/pnas.0407640102","article-title":"The initial substrate-binding site of \u03b3-secretase is located on presenilin near the active site","volume":"102","author":"Kornilova","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib47","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.26.041002.131334","article-title":"Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration","volume":"26","author":"Selkoe","year":"2003","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.nurt.2008.05.010_bib48","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","article-title":"Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/19083","article-title":"A presenilin-1-dependent \u03b3-secretase-like protease mediates release of Notch intracellular domain","volume":"398","author":"De Strooper","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/387288a0","article-title":"Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm","volume":"387","author":"Wong","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib51","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(00)80244-5","article-title":"Skeletal and CNS defects in presenilin-1-deficient mice","volume":"89","author":"Shen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.nurt.2008.05.010_bib52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1471-4159.2001.00012.x","article-title":"Functional \u03b3-secretase inhibitors reduce \u03b2-amyloid peptide levels in brain","volume":"76","author":"Dovey","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2008.05.010_bib53","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1124\/jpet.102.048280","article-title":"The \u03b3-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester reduces A\u03b2 levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice","volume":"305","author":"Lanz","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nurt.2008.05.010_bib54","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1124\/jpet.104.075408","article-title":"Dynamics of \u03b2-amyloid reductions in brain, cerebrospinal fluid, and plasma of \u03b2-amyloid precursor protein transgenic mice treated with a \u03b3-secretase inhibitor","volume":"312","author":"Barten","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nurt.2008.05.010_bib55","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2004.11.015","article-title":"Reductions in \u03b2-amyloid concentrations in vivo by the \u03b3-secretase inhibitors BMS-289948 and BMS-299897","volume":"69","author":"Anderson","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nurt.2008.05.010_bib56","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1124\/jpet.104.081174","volume":"313","author":"Best","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nurt.2008.05.010_bib57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.wnf.0000167360.27670.29","article-title":"Safety, tolerability, and changes in amyloid \u03b2 concentrations after administration of a \u03b3-secretase inhibitor in volunteers","volume":"28","author":"Siemers","year":"2005","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.nurt.2008.05.010_bib58","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1212\/01.WNL.0000198762.41312.E1","article-title":"Effects of a \u03b3-secretase inhibitor in a randomized study of patients with Alzheimer disease","volume":"66","author":"Siemers","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2008.05.010_bib59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/WNF.0b013e31805b7660","article-title":"Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-\u03b2 after inhibition of \u03b3-secretase","volume":"30","author":"Siemers","year":"2007","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.nurt.2008.05.010_bib60","doi-asserted-by":"crossref","first-page":"46107","DOI":"10.1074\/jbc.M307757200","article-title":"Adipsin: a biomarker of gastrointestinal toxicity mediated by a functional \u03b3 secretase inhibitor","volume":"278","author":"Searfoss","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib61","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1074\/jbc.M311652200","article-title":"Chronic treatment with the \u03b3-secretase inhibitor LY-411,575 inhibits \u03b2-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation","volume":"279","author":"Wong","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib62","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/35102591","article-title":"A subset of NSAIDs lower amyloidogenic A\u03b242 independently of cyclooxygenase activity","volume":"414","author":"Weggen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2008.05.010_bib63","doi-asserted-by":"crossref","first-page":"31831","DOI":"10.1074\/jbc.M303592200","article-title":"Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid \u03b242 production by direct modulation of \u03b3-secretase activity","volume":"278","author":"Weggen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib64","doi-asserted-by":"crossref","first-page":"43419","DOI":"10.1074\/jbc.M404937200","article-title":"Selected non-steroidal anti-inflammatory drugs and their derivatives target \u03b3-secretase at a novel site: evidence for an allosteric mechanism","volume":"279","author":"Beher","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib65","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.1074\/jbc.M513250200","article-title":"Secretion of the Notch-1 A\u03b2-like peptide during Notch signaling","volume":"281","author":"Okochi","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1172\/JCI18162","article-title":"NSAIDs and enantiomers of flurbiprofen target \u03b3-secretase and lower A\u03b2 42 in vivo","volume":"112","author":"Eriksen","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nurt.2008.05.010_bib67","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2202-8-54","article-title":"Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice","volume":"8","author":"Kukar","year":"2007","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.nurt.2008.05.010_bib68","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/WAD.0b013e31815d1048","article-title":"Safety, tolerability, pharmacokinetics, and A\u03b2 levels after short-term administration of R-flurbiprofen in healthy elderly individuals","volume":"21","author":"Galasko","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.nurt.2008.05.010_bib69","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1124\/jpet.107.129007","article-title":"1-(3\u2032,4\u2032-dichloro-2-fluoro[1,1\u2032-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel \u03b3-secretase modulator, reduces brain \u03b2-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity","volume":"323","author":"Imbimbo","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nurt.2008.05.010_bib70","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1523\/JNEUROSCI.22-06-02246.2002","article-title":"Microglial activation and \u03b2-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice","volume":"22","author":"Jantzen","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2008.05.010_bib71","doi-asserted-by":"crossref","first-page":"12444","DOI":"10.1073\/pnas.1534745100","article-title":"Gleevec inhibits \u03b2-amyloid production but not Notch cleavage","volume":"100","author":"Netzer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nurt.2008.05.010_bib72","doi-asserted-by":"crossref","first-page":"41987","DOI":"10.1074\/jbc.M501368200","article-title":"\u03b3-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide binding site","volume":"280","author":"Fraering","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2008.05.010_bib73","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm1406","article-title":"\u03b3-Secretase: proteasome of the membrane?","volume":"5","author":"Kopan","year":"2004","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923004968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747923004968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1016\/j.nurt.2008.05.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:38:08Z","timestamp":1761806288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747923004968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1878747923004968"],"URL":"https:\/\/doi.org\/10.1016\/j.nurt.2008.05.010","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition and Modulation of \u03b3-Secretase for Alzheimer's Disease","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nurt.2008.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}