{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:16:28Z","timestamp":1791303388846,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":4696,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.nurt.2010.05.013","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T05:55:05Z","timestamp":1285653305000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Strategies for Treatment in Alexander Disease"],"prefix":"10.1016","volume":"7","author":[{"given":"Albee","family":"Messing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M. LaPash","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Hagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nurt.2010.05.013_bib1","series-title":"Astrocytes in (Patho) Physiology of the Nervous System","first-page":"591","article-title":"Alexander disease: a genetic disorder of astrocytes","author":"Brenner","year":"2009"},{"key":"10.1016\/j.nurt.2010.05.013_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/brain\/72.3.373","article-title":"Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant","volume":"72","author":"Alexander","year":"1949","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2010.05.013_bib3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/00005072-197010000-00002","article-title":"Light and electron microscopic observations on Rosenthal fibers in Alexander's disease and in multiple sclerosis","volume":"29","author":"Herndon","year":"1970","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.nurt.2010.05.013_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0092-8674(89)90173-6","article-title":"\u03b1B-Crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain","volume":"57","author":"Iwaki","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.nurt.2010.05.013_bib5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-2990.2000.00269.x","article-title":"Small heat shock proteins, the cytoskeleton, and inclusion body formation","volume":"26","author":"Head","year":"2000","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.nurt.2010.05.013_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/83679","article-title":"Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease","volume":"27","author":"Brenner","year":"2001","journal-title":"Nature Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib7","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.yexcr.2007.04.004","article-title":"GFAP and its role in Alexander disease","volume":"313","author":"Quinlan","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.nurt.2010.05.013_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/504411","article-title":"The Alexander disease-causing GFAP mutant, R416W, accumulates into Rosenthal fibers by a pathway involving filament aggregation and the association of \u03b1B-crystallin and HSP27","volume":"79","author":"Perng","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib9","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/01.wnl.0000198770.80743.37","article-title":"Alexander disease: ventricular garlands and abnormalities of the medulla and spinal cord","volume":"66","author":"van der Knaap","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2010.05.013_bib10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1212\/01.wnl.0000200905.43191.4d","article-title":"Alexander disease: not just a leukodystrophy anymore","volume":"66","author":"Barkovich","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nurt.2010.05.013_bib11","first-page":"541","article-title":"Alexander disease: diagnosis with MR imaging","volume":"22","author":"van der Knaap","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.nurt.2010.05.013_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.20381","article-title":"Unusual variants of Alexander disease","volume":"57","author":"van der Knaap","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2010.05.013_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.bmt.1700871","article-title":"Allogeneic bone marrow transplantation for Alexanders disease","volume":"20","author":"Staba","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.nurt.2010.05.013_bib14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.braindev.2006.05.001","article-title":"TRH therapy in a patient with juvenile Alexander disease","volume":"28","author":"Ishigaki","year":"2006","journal-title":"Brain Dev"},{"key":"10.1016\/j.nurt.2010.05.013_bib15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.pnpbp.2009.11.021","article-title":"Ceftriaxone has a therapeutic role in Alexander disease","volume":"34","author":"Sechi","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.nurt.2010.05.013_bib16","first-page":"801","article-title":"Intermediate filament proteins","volume":"2","author":"Quinlan","year":"1995","journal-title":"Protein Profile"},{"key":"10.1016\/j.nurt.2010.05.013_bib17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00018-003-3143-3","article-title":"Alexander disease: putative mechanisms of an astrocytic encephalopathy","volume":"61","author":"Mignot","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.nurt.2010.05.013_bib18","first-page":"391","article-title":"Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice","volume":"152","author":"Messing","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib19","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1523\/JNEUROSCI.3260-06.2006","article-title":"Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response","volume":"26","author":"Hagemann","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/glia.20486","article-title":"The murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance","volume":"55","author":"Tanaka","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.nurt.2010.05.013_bib21","doi-asserted-by":"crossref","first-page":"38634","DOI":"10.1074\/jbc.M604942200","article-title":"Synergistic effects of the SAPK\/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease","volume":"281","author":"Tang","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib22","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2353\/ajpath.2006.051028","article-title":"Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease","volume":"168","author":"Tian","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0002-9440(10)64369-6","article-title":"p62 is a common component of cytoplasmic inclusions in protein aggregation diseases","volume":"160","author":"Zatloukal","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1523\/JNEUROSCI.20-01-00034.2000","article-title":"Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop","volume":"20","author":"Fern","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib25","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1523\/JNEUROSCI.20-24-09235.2000","article-title":"NBQX attenuates excitotoxic injury in developing white matter","volume":"20","author":"Follett","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib26","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1523\/JNEUROSCI.20-03-01190.2000","article-title":"Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter","volume":"20","author":"Li","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib27","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nature04474","article-title":"NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia","volume":"439","author":"Micu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2010.05.013_bib28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/NEN.0b013e3181d3cb52","article-title":"Alexander disease mutant GFAP compromises glutamate transport in astrocytes","volume":"69","author":"Tian","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.nurt.2010.05.013_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/glia.440110213","article-title":"Neurotransmitter-mediated signaling between axons and glial cells","volume":"11","author":"Chiu","year":"1994","journal-title":"Glia"},{"key":"10.1016\/j.nurt.2010.05.013_bib30","doi-asserted-by":"crossref","first-page":"RC16","DOI":"10.1523\/JNEUROSCI.19-14-j0002.1999","article-title":"Novel injury mechanism in anoxia and trauma of spinal cord white matter: glutamate release via reverse Na+-dependent glutamate transport","volume":"19","author":"Li","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-5728(94)90125-2","article-title":"Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumour necrosis factor","volume":"51","author":"Butt","year":"1994","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.nurt.2010.05.013_bib32","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/hmg\/ddi248","article-title":"Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction","volume":"14","author":"Hagemann","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib33","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1523\/JNEUROSCI.0341-09.2009","article-title":"Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation","volume":"29","author":"Lutz","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0896-6273(95)90238-4","article-title":"Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions","volume":"14","author":"Gomi","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.nurt.2010.05.013_bib35","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/j.1460-2075.1995.tb07147.x","article-title":"Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally","volume":"14","author":"Pekny","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.nurt.2010.05.013_bib36","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1073\/pnas.93.13.6361","article-title":"Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology","volume":"93","author":"McCall","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib37","first-page":"251","article-title":"Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion","volume":"152","author":"Liedtke","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib38","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1128\/IAI.73.12.7836-7843.2005","article-title":"Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response","volume":"73","author":"Kadurugamuwa","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.nurt.2010.05.013_bib39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1471-4159.2009.06146.x","article-title":"Dual transgenic reporter mice as a tool for monitoring expression of GFAP","volume":"110","author":"Cho","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2010.05.013_bib39a","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1093\/hmg\/ddq227","article-title":"Drug screening to identify suppressors of GFAP expression","volume":"19","author":"Cho","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib40","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2174\/092986709787581860","article-title":"Proteasome regulators: activators and inhibitors","volume":"16","author":"Huang","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib41","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/hmg\/ddn042","article-title":"Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38\/MAPK and mTOR signaling pathways","volume":"17","author":"Tang","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nature Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib43","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1523\/JNEUROSCI.0955-08.2008","article-title":"Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function","volume":"28","author":"Meikle","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.21331","article-title":"Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex","volume":"63","author":"Zeng","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nurt.2010.05.013_bib45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/brain\/awp292","article-title":"Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3","volume":"133","author":"Menzies","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nurt.2010.05.013_bib46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2010.05.013_bib47","doi-asserted-by":"crossref","first-page":"33791","DOI":"10.1074\/jbc.M204861200","article-title":"Glycogen synthase kinase-3 beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation","volume":"277","author":"Carmichael","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib48","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.200504035","article-title":"Lithium induces autophagy by inhibiting inositol monophosphatase","volume":"17","author":"Sarkar","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nurt.2010.05.013_bib49","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1073\/pnas.0708022105","article-title":"Lithium delays progression of amyotrophic lateral sclerosis","volume":"105","author":"Fornai","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib50","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1093\/hmg\/ddi331","article-title":"Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway","volume":"14","author":"Berger","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib51","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1073\/pnas.0500466102","article-title":"Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo","volume":"102","author":"Noble","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/hmg\/ddm294","article-title":"A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin","volume":"17","author":"Sarkar","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib53","first-page":"487","article-title":"Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers","volume":"143","author":"Iwaki","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib54","first-page":"345","article-title":"Accumulation of \u03b1B-crystallin in central nervous system glia and neurons in pathologic conditions","volume":"140","author":"Iwaki","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib55","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/hmg\/ddp013","article-title":"Suppression of GFAP toxicity by \u03b1B-crystallin in mouse models of Alexander disease","volume":"18","author":"Hagemann","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib56","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.125.6.1385","article-title":"Sense and antisense modification of glial \u03b1B-crystallin production results in alterations of stress fiber formation and thermoresistance","volume":"125","author":"Iwaki","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nurt.2010.05.013_bib57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00424-005-0033-6","article-title":"Expression and regulation of \u03b1B-crystallin in the kidney in vivo and in vitro","volume":"452","author":"Michl","year":"2006","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1016\/j.nurt.2010.05.013_bib58","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1242\/jcs.109.5.1029","article-title":"Transcriptional regulation of \u03b1B-crystallin in astrocytes: analysis of HSF and AP1 activation by different types of physiological stress","volume":"109","author":"Head","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.nurt.2010.05.013_bib59","doi-asserted-by":"crossref","first-page":"C903","DOI":"10.1152\/ajpcell.1996.270.3.C903","article-title":"\u03b1B-crystallin protects glial cells from hypertonic stress","volume":"270","author":"Kegel","year":"1996","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.nurt.2010.05.013_bib60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.RES.0000052989.83995.A5","article-title":"Mimicking phosphorylation of \u03b1B-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis","volume":"92","author":"Morrison","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.nurt.2010.05.013_bib61","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1161\/01.CIR.96.12.4343","article-title":"Small heat shock proteins and protection against ischemic injury in cardiac myocytes","volume":"96","author":"Martin","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.nurt.2010.05.013_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jcp.1041590107","article-title":"Coordinate and independent regulation of alpha B-crystallin and hsp27 expression in response to physiological stress","volume":"159","author":"Head","year":"1994","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nurt.2010.05.013_bib63","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/j.1460-2075.1994.tb06339.x","article-title":"Chaperone activity of \u03b1-crystallins modulates intermediate filament assembly","volume":"13","author":"Nicholl","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.nurt.2010.05.013_bib64","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0002-9440(10)65409-0","article-title":"Formation of GFAP cytoplasmic inclusions in astrocytes and their disaggregation by \u03b1B-crystallin","volume":"154","author":"Koyama","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nurt.2010.05.013_bib65","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/sj.ejhg.5201995","article-title":"Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease","volume":"16","author":"Bachetti","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.nurt.2010.05.013_bib66","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1096\/fj.00-0199com","article-title":"Transgene overexpression of \u03b1B crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion","volume":"15","author":"Ray","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.nurt.2010.05.013_bib67","doi-asserted-by":"crossref","first-page":"10527","DOI":"10.1074\/jbc.M109.067975","article-title":"Oligomers of mutant glial fibrillary acidic protein (GFAP) inhibit the proteasome system in Alexander disease astrocytes, and the small heat shock protein, \u03b1B-crystallin, reverses the inhibition","volume":"285","author":"Tang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib68","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.freeradbiomed.2004.04.033","article-title":"The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress","volume":"37","author":"Nguyen","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nurt.2010.05.013_bib69","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1046\/j.1471-4159.2002.00913.x","article-title":"Activation of the antioxidant responsive element in primary cortical neuronal cultures derived from transgenic reporter mice","volume":"81","author":"Johnson","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2010.05.013_bib70","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1523\/JNEUROSCI.3817-03.2004","article-title":"Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult","volume":"24","author":"Kraft","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib71","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1073\/pnas.0408487101","article-title":"Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription","volume":"102","author":"Calkins","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib72","doi-asserted-by":"crossref","first-page":"22925","DOI":"10.1074\/jbc.M414635200","article-title":"Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo","volume":"280","author":"Shih","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib73","doi-asserted-by":"crossref","first-page":"13574","DOI":"10.1523\/JNEUROSCI.4099-08.2008","article-title":"Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis","volume":"25","author":"Vargas","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.nurt.2010.05.013_bib74","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1073\/pnas.0813361106","article-title":"Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte","volume":"106","author":"Chen","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib75","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.M209195200","article-title":"Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium","volume":"278","author":"Stewart","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nurt.2010.05.013_bib76","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1073\/pnas.94.19.10367","article-title":"Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens","volume":"94","author":"Fahey","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nurt.2010.05.013_bib77","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nurt.2010.05.013_bib78","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1471-4159.2006.03743.x","article-title":"Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1\/EAAT2 subtype","volume":"97","author":"Li","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2010.05.013_bib79","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuint.2008.07.010","article-title":"Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1","volume":"53","author":"Sheldon","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1016\/j.nurt.2010.05.013_bib80","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuint.2007.08.020","article-title":"Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester","volume":"52","author":"Susarla","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1016\/j.nurt.2010.05.013_bib81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"\u03b2-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.nurt.2010.05.013_bib82","doi-asserted-by":"crossref","first-page":"e3149","DOI":"10.1371\/journal.pone.0003149","article-title":"A \u03b2-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis","volume":"3","author":"Melzer","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nurt.2010.05.013_bib83","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1471-4159.2009.06347.x","article-title":"Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro","volume":"111","author":"Lewerenz","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.nurt.2010.05.013_bib84","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.yexcr.2008.12.012","article-title":"Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice","volume":"315","author":"Cho","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.nurt.2010.05.013_bib85","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1172\/JCI38003","article-title":"Dysfunctions of neuronal and glial intermediate filaments in disease","volume":"119","author":"Liem","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nurt.2010.05.013_bib86","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2005-872876","article-title":"Increased levels of GFAP in the cerebrospinal fluid in three subtypes of genetically confirmed Alexander disease","volume":"36","author":"Kyllerman","year":"2005","journal-title":"Neuropediatrics"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792300199X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792300199X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1016\/j.nurt.2010.05.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:37:36Z","timestamp":1761806256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187874792300199X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S187874792300199X"],"URL":"https:\/\/doi.org\/10.1016\/j.nurt.2010.05.013","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strategies for Treatment in Alexander Disease","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nurt.2010.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}