{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:32:03Z","timestamp":1786995123058,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T00:00:00Z","timestamp":1293580800000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.nut.2009.08.026","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T04:29:38Z","timestamp":1262147378000},"page":"1021-1028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Study of lymphocyte subpopulations in bone marrow in a model of protein\u2013energy malnutrition"],"prefix":"10.1016","volume":"26","author":[{"given":"Ricardo Ambr\u00f3sio","family":"Fock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange L\u00facia","family":"Blatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Beutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela","family":"Tsujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Erivaldo Vidal","family":"de Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primavera","family":"Borelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2009.08.026_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1753-4887.2000.tb07797.x","article-title":"Nutrition and infection: malnutrition and mortality in public health","volume":"58","author":"Brundtland","year":"2000","journal-title":"Nutr Rev"},{"key":"10.1016\/j.nut.2009.08.026_bib2","first-page":"336S","article-title":"History of nutrition: malnutrition, infection and immunity","volume":"133","author":"Keusch","year":"2003","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.nut.2009.08.026_bib3","volume":"Volume 555","author":"Waterlow","year":"1996"},{"key":"10.1016\/j.nut.2009.08.026_bib4","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.ejcn.1601485","article-title":"The thymus gland is a target in malnutrition","volume":"56","author":"Savino","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nut.2009.08.026_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0899-9007(01)00578-0","article-title":"Malnutrition, nutrition indices, and early enteral feeding in critically ill children","volume":"17","author":"Briassoulis","year":"2001","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2009.08.026_bib6","series-title":"Modern nutrition in health diseases","first-page":"1241","article-title":"Nutrition and infection","author":"Keusch","year":"1994"},{"key":"10.1016\/j.nut.2009.08.026_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1152\/physrev.1980.60.1.188","article-title":"Role of nutrition in immunologic function","volume":"60","author":"Gross","year":"1980","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nut.2009.08.026_bib8","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1038\/sj.ejcn.1601482","article-title":"The adaptive response of the immune system to the particular malnutrition of eating disorders","volume":"56","author":"Nova","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nut.2009.08.026_bib9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1590\/S0100-879X2000000800004","article-title":"Alteration of the bone marrow in extracellular matrix in mice undernourished","volume":"33","author":"Vituri","year":"2001","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.nut.2009.08.026_bib10","first-page":"651","article-title":"Protein\u2013energy malnutrition alters histological and ultrastructural characteristics of the bone marrow and decreases haematopoiesis in adult mice","volume":"22","author":"Xavier","year":"2007","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.nut.2009.08.026_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0100-879X2009000600008","article-title":"Protein\u2013energy malnutrition halts hemopoietic progenitor cells in the G0\/G1 cell cycle stage, thereby altering cell production rates","volume":"42","author":"Borelli","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.nut.2009.08.026_bib12","first-page":"657","article-title":"Flow cytometric analysis of human bone marrow. III. Neutrophil maturation","volume":"4","author":"Terstappen","year":"1990","journal-title":"Leukemia"},{"key":"10.1016\/j.nut.2009.08.026_bib13","series-title":"Human nutrition\u2014a comprehensive treatise","first-page":"121","volume":"Volume 8","author":"Kuvibidila","year":"1993"},{"key":"10.1016\/j.nut.2009.08.026_bib14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0277-5379(89)90153-3","article-title":"Dietary influences on cell proliferation in bone marrow","volume":"25","author":"Dunki Jacobs","year":"1989","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.1016\/j.nut.2009.08.026_bib15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2249.2008.03796.x","article-title":"Malnutrition alters the rates of apoptosis in splenocytes and thymocyte subpopulations of rats","volume":"155","author":"Ortiz","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nut.2009.08.026_bib16","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1017\/S0007114507832880","article-title":"The thymus is a common target in malnutrition and infection","volume":"98","author":"Savino","year":"2007","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2009.08.026_bib17","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2009.08.026_bib18","first-page":"191","article-title":"A micro-Kjeldahl procedure for field use","volume":"20","author":"Ward","year":"1963","journal-title":"J Med Lab Technol"},{"key":"10.1016\/j.nut.2009.08.026_bib19","series-title":"Practical haematology","author":"Dacie","year":"1995"},{"key":"10.1016\/j.nut.2009.08.026_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","article-title":"Albumin standards and the measurement of serum albumin with bromcresol green","volume":"31","author":"Doumas","year":"1971","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.nut.2009.08.026_bib21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2009.08.026_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/clin.1996.0108","article-title":"Reversible effects on B and T cells of the gut-associated lymphoid tissues in rats malnourished during suckling: impaired induction of the immune response to intra-Peyer patches immunization with cholera toxin","volume":"80","author":"Fl\u00f3","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.nut.2009.08.026_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cyto.2007.08.007","article-title":"Protein\u2013energy malnutrition decreases the expression of TLR-4\/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in mice","volume":"40","author":"Fock","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.nut.2009.08.026_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.20008","article-title":"Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: reference patterns for age-related changes and disease-induced shifts","volume":"60","author":"van Lochem","year":"2004","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.nut.2009.08.026_bib25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.176.5.1241","article-title":"CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation","volume":"176","author":"Kato","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.nut.2009.08.026_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0167-5699(96)80617-7","article-title":"The structure and ligand interactions of CD2: implications for T-cell function","volume":"17","author":"Davis","year":"1996","journal-title":"Immunol Today"},{"key":"10.1016\/j.nut.2009.08.026_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.181.1.375","article-title":"ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity","volume":"181","author":"Isakov","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.nut.2009.08.026_bib28","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.4049\/jimmunol.145.10.3209","article-title":"Unusual T cell populations in adult murine bone marrow. Prevalence of CD3 + CD4 \u2212 CD8\u2212 and alpha beta TCR + NK1.1+ cells","volume":"145","author":"Sykes","year":"1990","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.nut.2009.08.026_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbrc.2009.04.134","article-title":"the role of CD4 T cell help for CD8 CTL activation","volume":"384","author":"Zhang","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nut.2009.08.026_bib30","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.4049\/jimmunol.167.5.2469","article-title":"A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice","volume":"167","author":"Hasegawa","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2009.08.026_bib31","first-page":"239","article-title":"The role of CD5-expressing B cells in health and disease","volume":"3","author":"Pers","year":"1999","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nut.2009.08.026_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-5710(97)00060-1","article-title":"Characterization of leukemic cells in CD2\/CD19 double positive acute lymphoblastic leukemia","volume":"67","author":"Manabe","year":"1998","journal-title":"Int J Hematol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900709003670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900709003670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:05:11Z","timestamp":1760270711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900709003670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0899900709003670"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2009.08.026","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of lymphocyte subpopulations in bone marrow in a model of protein\u2013energy malnutrition","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2009.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}