{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:39:30Z","timestamp":1790872770326,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.nut.2012.01.005","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T07:51:58Z","timestamp":1337068318000},"page":"e23-e26","source":"Crossref","is-referenced-by-count":92,"title":["Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes"],"prefix":"10.1016","volume":"28","author":[{"given":"Masoud Y.","family":"Al-Maskari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa I.","family":"Waly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra S.","family":"Al-Shuaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allal","family":"Ouhtit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2012.01.005_bib1","series-title":"Modern nutrition in health and disease","author":"Shils","year":"2006"},{"key":"10.1016\/j.nut.2012.01.005_bib2","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1096\/fj.09-143651","article-title":"Regulation of homocysteine metabolism and methylation in human and mouse tissues","volume":"24","author":"Chen","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2012.01.005_bib3","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1289\/ehp.0900741","article-title":"Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation","volume":"117","author":"Lee","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.nut.2012.01.005_bib4","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1021\/tx0497898","article-title":"A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics","volume":"17","author":"Watson","year":"2004","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.nut.2012.01.005_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2012.01.005_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1289\/ehp.02110s125","article-title":"Understanding the human health effects of chemical mixtures","volume":"110","author":"Carpenter","year":"2002","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.nut.2012.01.005_bib7","first-page":"124","article-title":"Pro-inflammatory cytokines in Omani type 2 diabetic patients presenting anxiety and depression","volume":"7","author":"Al-Maskari","year":"2010","journal-title":"Iran J\u00a0Immunol"},{"key":"10.1016\/j.nut.2012.01.005_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2891-3-4","article-title":"Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation","volume":"3","author":"Hayden","year":"2004","journal-title":"Nutr J"},{"key":"10.1016\/j.nut.2012.01.005_bib9","first-page":"691","article-title":"Is hyperhomocysteinemia due to oxidative depletion of folate rather than to insufficiency dietary intake?","volume":"39","author":"Fuchs","year":"2001","journal-title":"Clin Chem Med"},{"key":"10.1016\/j.nut.2012.01.005_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/1389200024605091","article-title":"Hyperhomocysteinemia, pteridines and oxidative stress","volume":"3","author":"Widner","year":"2002","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.nut.2012.01.005_bib11","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.1993.03510220049033","article-title":"Vitamin status and intake as primary determinant of homocystinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.nut.2012.01.005_bib12","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1177\/15648265080292S110","article-title":"The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status","volume":"29","author":"Selhub","year":"2008","journal-title":"Food Nutr Bull"},{"key":"10.1016\/j.nut.2012.01.005_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7326\/0003-4819-131-5-199909070-00003","article-title":"Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991\u20131994): population reference ranges and contribution of vitamin status to high serum concentrations","volume":"131","author":"Selhub","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nut.2012.01.005_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(94)90149-X","article-title":"Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies","volume":"96","author":"Savage","year":"1994","journal-title":"Am J Med"},{"key":"10.1016\/j.nut.2012.01.005_bib15","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1096\/fasebj.7.14.7901104","article-title":"Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency","volume":"7","author":"Allen","year":"1993","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2012.01.005_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1467-789X.2010.00750.x","article-title":"The prevalence and trends of overweight, obesity and nutrition-related non-communicable diseases in the Arabian Gulf States","volume":"12","author":"Ng","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.nut.2012.01.005_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.26719\/2009.15.1.209","article-title":"Epidemiological transition of some diseases in Oman: a situational analysis","volume":"15","author":"Ganguly","year":"2009","journal-title":"East Mediterr Health J"},{"key":"10.1016\/j.nut.2012.01.005_bib18","first-page":"160","article-title":"Follow-up report on the diagnosis of diabetes mellitus","volume":"26","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2012.01.005_bib19","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/68.4.899","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults","volume":"68","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2012.01.005_bib20","series-title":"Food frequency methods in nutritional epidemiology","author":"Willet","year":"1988"},{"key":"10.1016\/j.nut.2012.01.005_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00001648-199001000-00013","article-title":"A reduced dietary questionnaire: development and validation","volume":"1","author":"Block","year":"1990","journal-title":"Epidemiology"},{"key":"10.1016\/j.nut.2012.01.005_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/oxfordjournals.aje.a115013","article-title":"Reproducibility and validity of dietary assessment instruments. I. A self-administered food use questionnaire with a portion size picture booklet","volume":"128","author":"Pietinen","year":"1988","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.nut.2012.01.005_bib23","series-title":"Practical clinical biochemistry","author":"Varely","year":"1980"},{"key":"10.1016\/j.nut.2012.01.005_bib24","first-page":"235","article-title":"Determination of folate and vitamin B12 by ADVIA Centaur","volume":"29","author":"Kei","year":"2006","journal-title":"J Anal Biosci"},{"key":"10.1016\/j.nut.2012.01.005_bib25","first-page":"699","article-title":"Plasma determination of homocysteine on CPC Immulite 2000: comparison with determination on IMX Abbott","volume":"61","author":"Quillard","year":"2003","journal-title":"Ann Biol Clin"},{"key":"10.1016\/j.nut.2012.01.005_bib26","series-title":"Food and Nutrition Board, Institute of Medicine. Dietary reference intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline","year":"1998"},{"key":"10.1016\/j.nut.2012.01.005_bib27","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/clinchem\/44.2.311","article-title":"Enzyme conversion immunoassay for determining total homocysteine in plasma or serum","volume":"44","author":"Frantzen","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.nut.2012.01.005_bib28","first-page":"S53","article-title":"Low dose folic acid supplementation decrease plasma homocysteine concentration: a randomized trial","volume":"52","author":"Brouwer","year":"2000","journal-title":"Indian Heart J"},{"key":"10.1016\/j.nut.2012.01.005_bib29","doi-asserted-by":"crossref","unstructured":"Tice JA, Rose E, Coxson PG, Rosenberg I, Weinstein MC, Hunink MG, et\u00a0al. Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease. Effect of grain fortification and beyond. JAMA;286:936\u201343.","DOI":"10.1001\/jama.286.8.936"},{"key":"10.1016\/j.nut.2012.01.005_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0891-5849(94)90079-5","article-title":"Importance of Se-glutathione peroxidase, catalase, and Cu\/Zn-SOD for cell survival against oxidative stress","volume":"17","author":"Michiels","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nut.2012.01.005_bib31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s001250050729","article-title":"Relationship between plasma measures of oxidative stress and metabolic control in NIDDM","volume":"40","author":"Nouroz-Zadeh","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.nut.2012.01.005_bib32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0188-4409(01)00285-5","article-title":"Catalase\/superoxide dismutase (SOD) and catalase\/paraoxonase (PON) ratio may implicate poor glycemic control","volume":"32","author":"S\u00f6zmen","year":"2001","journal-title":"Arch Med Res"},{"key":"10.1016\/j.nut.2012.01.005_bib33","first-page":"682","article-title":"Lipid peroxidation and antioxidant enzyme activities in erythrocytes of type 2 diabetic patients","volume":"93","author":"Likidlilid","year":"2010","journal-title":"J\u00a0Med Assoc Thai"},{"key":"10.1016\/j.nut.2012.01.005_bib34","first-page":"433","article-title":"Blood antioxidant parameters in patients with diabetic retinopathy","volume":"14","author":"Siemianowicz","year":"2004","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nut.2012.01.005_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-8227(01)00238-8","article-title":"Lipid peroxidation and antioxidant enzyme status in type 2 diabetics with coronary heart disease","volume":"53","author":"Kesavulu","year":"2001","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900712000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900712000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T17:44:07Z","timestamp":1594143847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900712000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":35,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0899900712000408"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2012.01.005","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}