{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:30:48Z","timestamp":1789680648546,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.nut.2012.02.013","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T02:20:29Z","timestamp":1340072429000},"page":"1055-1062","source":"Crossref","is-referenced-by-count":78,"title":["Caffeine attenuates metabolic syndrome in diet-induced obese rats"],"prefix":"10.1016","volume":"28","author":[{"given":"Sunil K.","family":"Panchal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng-Yew","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Kauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh C.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2012.02.013_bib1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0278-6915(02)00096-0","article-title":"Effects of caffeine on human behavior","volume":"40","author":"Smith","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nut.2012.02.013_bib2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.nut.2010.08.004","article-title":"Caffeine\u2014Not just a stimulant","volume":"26","author":"Glade","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2012.02.013_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-642-13443-2_3","article-title":"Pharmacokinetics and metabolism of natural methylxanthines in animal and man","volume":"200","author":"Arnaud","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1467-789X.2011.00908.x","article-title":"Fat burners: nutrition supplements that increase fat metabolism","volume":"12","author":"Jeukendrup","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.nut.2012.02.013_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-540-89615-9_1","article-title":"Introduction to adenosine receptors as therapeutic targets","volume":"193","author":"Jacobson","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/14728214.12.3.479","article-title":"Emerging adenosine receptor agonists","volume":"12","author":"Gao","year":"2007","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.nut.2012.02.013_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/1074248410396877","article-title":"Adenosine receptor-mediated cardioprotection","volume":"17","author":"McIntosh","year":"2012","journal-title":"J\u00a0Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.nut.2012.02.013_bib8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.bjp.0704586","article-title":"Tonic activity of the rat adipocyte A1-adenosine receptor","volume":"135","author":"Liang","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ijo.2011.129","article-title":"Contrasting effects of A1 and A2b\u00a0adenosine receptors on adipogenesis","volume":"36","author":"Gharibi","year":"2012","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.nut.2012.02.013_bib10","first-page":"86","article-title":"Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats","volume":"107","author":"Conde","year":"2012","journal-title":"Br J\u00a0Nutr"},{"key":"10.1016\/j.nut.2012.02.013_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/hep.23279","article-title":"Increased caffeine consumption is associated with reduced hepatic fibrosis","volume":"51","author":"Modi","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2012.02.013_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/FJC.0b013e3181feb90a","article-title":"High-carbohydrate, high-fat diet\u2013induced metabolic syndrome and cardiovascular remodeling in rats","volume":"57","author":"Panchal","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jnutbio.2010.11.011","article-title":"Lipid redistribution by alpha-linolenic acid\u2013rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats","volume":"23","author":"Poudyal","year":"2012","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2012.02.013_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.nut.2012.02.013_bib15","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1111\/j.1750-3841.2010.01561.x","article-title":"Caffeine (1,3,7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters","volume":"75","author":"Heckman","year":"2010","journal-title":"J Food Sci"},{"key":"10.1016\/j.nut.2012.02.013_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1257\/jep.25.1.139","article-title":"Who pays for obesity?","volume":"25","author":"Bhattacharya","year":"2011","journal-title":"J Econ Perspect"},{"key":"10.1016\/j.nut.2012.02.013_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0265203021000007840","article-title":"Effects of caffeine on human health","volume":"20","author":"Nawrot","year":"2003","journal-title":"Food Addit Contam"},{"issue":"suppl 1","key":"10.1016\/j.nut.2012.02.013_bib18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JAD-2010-1379","article-title":"Caffeine and adenosine","volume":"20","author":"Ribeiro","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.nut.2012.02.013_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ardp.19913240502","article-title":"Biochemical mechanism of caffeine tolerance","volume":"324","author":"Ammon","year":"1991","journal-title":"Arch Pharm (Weinheim)"},{"key":"10.1016\/j.nut.2012.02.013_bib20","first-page":"62","article-title":"Role of adenosine receptors in caffeine tolerance","volume":"256","author":"Holtzman","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nut.2012.02.013_bib21","first-page":"801","article-title":"Caffeine during pregnancy? In moderation","volume":"46","author":"Koren","year":"2000","journal-title":"Can Fam Phys"},{"key":"10.1016\/j.nut.2012.02.013_bib22","doi-asserted-by":"crossref","first-page":"E671","DOI":"10.1152\/ajpendo.1995.269.4.E671","article-title":"Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women","volume":"269","author":"Bracco","year":"1995","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2012.02.013_bib23","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1271\/bbb.69.2219","article-title":"Effect of caffeine on the body fat and lipid metabolism of rats fed on a high-fat diet","volume":"69","author":"Kobayashi-Hattori","year":"2005","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.nut.2012.02.013_bib24","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1517\/13543780802497284","article-title":"A1 adenosine receptor agonists and their potential therapeutic applications","volume":"17","author":"Elzein","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.nut.2012.02.013_bib25","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1161\/CIRCULATIONAHA.106.620211","article-title":"Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function","volume":"114","author":"Funakoshi","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.nut.2012.02.013_bib26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.33549\/physiolres.931467","article-title":"Effects of adenosine A1 receptor antagonism on lipogenesis and lipolysis in isolated rat adipocytes","volume":"58","author":"Szkudelski","year":"2009","journal-title":"Physiol Res"},{"key":"10.1016\/j.nut.2012.02.013_bib27","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/sj.bjp.0706812","article-title":"Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis","volume":"148","author":"Chan","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib28","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI37409","article-title":"Adenosine signaling contributes to ethanol-induced fatty liver in mice","volume":"119","author":"Peng","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2012.02.013_bib29","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1161\/ATVBAHA.111.236554","article-title":"Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding","volume":"31","author":"Handa","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nut.2012.02.013_bib30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/sj.bjp.0707459","article-title":"Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus","volume":"153","author":"Schafer","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2003-39781","article-title":"Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes","volume":"111","author":"Boden","year":"2003","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.nut.2012.02.013_bib32","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1016\/0006-2952(89)90560-1","article-title":"Effects of caffeine on urea biosynthesis and some related processes, ketone bodies, ATP and liver amino acids","volume":"38","author":"Jorda","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nut.2012.02.013_bib33","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/art.22762","article-title":"Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey","volume":"57","author":"Choi","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.nut.2012.02.013_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0022-3956(84)90001-3","article-title":"Behavioral and molecular actions of caffeine: focus on adenosine","volume":"18","author":"Snyder","year":"1984","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.nut.2012.02.013_bib35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1289\/ehp.96104400","article-title":"Scaling basic toxicokinetic parameters from rat to man","volume":"104","author":"Bachmann","year":"1996","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.nut.2012.02.013_bib36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900712000913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900712000913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T17:54:24Z","timestamp":1642528464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900712000913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0899900712000913"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2012.02.013","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}