{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:41:57Z","timestamp":1773430917813,"version":"3.50.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["nutritionjrnl.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.nut.2013.11.001","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T14:10:17Z","timestamp":1384524617000},"page":"733-738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Can \u03c9-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders?"],"prefix":"10.1016","volume":"30","author":[{"given":"Eric","family":"Gumpricht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie","family":"Rockway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2013.11.001_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/MOP.0b013e328352c5a6","article-title":"Clear as mud: another look at autism, childhood apraxia of speech and auditory processing","volume":"24","author":"Tierney","year":"2012","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.nut.2013.11.001_bib2","first-page":"103","article-title":"A Cochrane review of treatment for childhood apraxia of speech","volume":"45","author":"Morgan","year":"2009","journal-title":"Eur J Phys Rehabil Med"},{"key":"10.1016\/j.nut.2013.11.001_bib3","first-page":"1","article-title":"Prevalence of autism spectrum disorders\u2014Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008","volume":"61","author":"Wingate","year":"2012","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.nut.2013.11.001_bib4","first-page":"104","article-title":"The worldwide prevalence of ADHD: is it an American condition?","volume":"2","author":"Faraone","year":"2003","journal-title":"World Psychiatry"},{"key":"10.1016\/j.nut.2013.11.001_bib5","unstructured":"Delaney AL, Kent RD. Developmental profiles of children diagnosed with apraxia of speech. Poster session presented at: The annual convention of the American-Speech-Language-Hearing Association. November 18\u201320, 2004; Philadelphia."},{"key":"10.1016\/j.nut.2013.11.001_bib6","first-page":"34","article-title":"Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation","volume":"15","author":"Morris","year":"2009","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.nut.2013.11.001_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/15374410701817808","article-title":"Evidence-based comprehensive treatments for early autism","volume":"37","author":"Rogers","year":"2008","journal-title":"J Clin Child Adolesc Psychol"},{"key":"10.1016\/j.nut.2013.11.001_bib8","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1301\/nr.2006.may.S24-S33","article-title":"Nutrition in brain development and aging: role of essential fatty acids","volume":"64","author":"Uauy","year":"2006","journal-title":"Nutr Rev"},{"key":"10.1016\/j.nut.2013.11.001_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1024\/0300-9831.70.2.31","article-title":"Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review","volume":"70","author":"Valk","year":"2000","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.nut.2013.11.001_bib10","series-title":"Treating Attention Deficit Disorder","article-title":"Ingestible alternative and complementary treatments for attention-deficit\/hyperactivity disorder (ADHD)","author":"Arnold","year":"2011"},{"key":"10.1016\/j.nut.2013.11.001_bib11","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11745-006-1155-0","article-title":"EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors","volume":"38","author":"Stevens","year":"2003","journal-title":"Lipids"},{"issue":"Suppl","key":"10.1016\/j.nut.2013.11.001_bib12","doi-asserted-by":"crossref","first-page":"327S","DOI":"10.1093\/ajcn\/71.1.327S","article-title":"Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder","volume":"71","author":"Burgess","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/aje\/kws433","article-title":"Maternal dietary fat intake in association with autism spectrum disorders","volume":"178","author":"Lyall","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.nut.2013.11.001_bib14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.amepre.2005.06.008","article-title":"A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development","volume":"29","author":"Cohen","year":"2005","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.nut.2013.11.001_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/1367493511403953","article-title":"Polyunsaturated fatty acids, cognition and literacy in children with ADHD with and without learning difficulties","volume":"15","author":"Milte","year":"2011","journal-title":"J Child Health Care"},{"key":"10.1016\/j.nut.2013.11.001_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phanu.2012.10.004","article-title":"Role of long-chain \u03c9-3 fatty acids in psychiatric practice","author":"McNamara","year":"2013","journal-title":"PharmaNutrition"},{"key":"10.1016\/j.nut.2013.11.001_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12011-010-8840-9","article-title":"Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation","volume":"143","author":"Meguid","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.nut.2013.11.001_bib18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.biopsych.2006.05.007","article-title":"Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study","volume":"61","author":"Amminger","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.nut.2013.11.001_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1067\/mpd.2001.116050","article-title":"A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit\/hyperactivity disorder","volume":"139","author":"Voigt","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.nut.2013.11.001_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.ejcn.1601830","article-title":"Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit\/hyperactivity disorder\u2014a placebo-controlled double-blind study","volume":"58","author":"Hirayama","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.plefa.2009.05.004","article-title":"Toxicology and safety of DHA","volume":"81","author":"Lien","year":"2009","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.nut.2013.11.001_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0361-9230(01)00551-2","article-title":"The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects","volume":"56","author":"Carver","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.nut.2013.11.001_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.nutr.012809.104635","article-title":"Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases","volume":"31","author":"Bazan","year":"2011","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-4157(84)90005-4","article-title":"The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function","volume":"779","author":"Stubbs","year":"1984","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nut.2013.11.001_bib25","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1176\/appi.ajp.161.10.1922","article-title":"Omega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorder","volume":"161","author":"Hirashima","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.nut.2013.11.001_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mam.2011.10.002","article-title":"n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization","volume":"33","author":"Shaikh","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.nut.2013.11.001_bib27","doi-asserted-by":"crossref","first-page":"e28451","DOI":"10.1371\/journal.pone.0028451","article-title":"Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood","volume":"6","author":"Bhatia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2013.11.001_bib28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1203\/01.pdr.0000182188.31596.5a","article-title":"Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys","volume":"58","author":"Anderson","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.nut.2013.11.001_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1471-4159.2006.04371.x","article-title":"Modulation of inflammation in brain: a matter of fat","volume":"101","author":"Farooqui","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.nut.2013.11.001_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2174\/092986712798918851","article-title":"n-3 fatty acid-derived lipid mediators in the brain: new weapons against oxidative stress and inflammation","volume":"19","author":"Farooqui","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.nut.2013.11.001_bib31","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.bcp.2012.08.004","article-title":"Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders","volume":"84","author":"Lee","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nut.2013.11.001_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1742-2094-10-46","article-title":"Focal brain inflammation and autism","volume":"10","author":"Theoharides","year":"2013","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.nut.2013.11.001_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbadis.2010.12.017","article-title":"Mast cell activation and autism","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nut.2013.11.001_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-11-25","article-title":"Multiple roles of dihomo-\u03b3-linolenic acid against proliferation diseases","volume":"11","author":"Wang","year":"2012","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nut.2013.11.001_bib35","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0090-6980(88)90116-5","article-title":"Oxidative metabolism of dihomogammalinolenic acid by guinea pig epidermis: evidence of generation of anti-inflammatory products","volume":"35","author":"Miller","year":"1988","journal-title":"Prostaglandins"},{"key":"10.1016\/j.nut.2013.11.001_bib36","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.4049\/jimmunol.174.9.5390","article-title":"Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4","volume":"174","author":"Weatherhill","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2013.11.001_bib37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-511X-9-12","article-title":"Docosahexaenoic acid prevents dendritic cell maturation and in\u00a0vitro and in\u00a0vivo expression of the IL-12 cytokine family","volume":"9","author":"Kong","year":"2010","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nut.2013.11.001_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12640-013-9393-4","article-title":"Altered cytokine and BDNF levels in autism spectrum disorder","volume":"24","author":"Ricci","year":"2013","journal-title":"Neurotox Res"},{"key":"10.1016\/j.nut.2013.11.001_bib39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-2094-8-52","article-title":"IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation","volume":"8","author":"Wei","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.nut.2013.11.001_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1742-2094-10-72","article-title":"Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children","volume":"10","author":"Al-Ayadhi","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.nut.2013.11.001_bib41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1742-2094-9-158","article-title":"Elevated serum levels of interleukin-17 A in children with autism","volume":"9","author":"Al-Ayadhi","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.nut.2013.11.001_bib42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nut.2013.11.001_bib43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/10284150310001612203","article-title":"Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder","volume":"6","author":"Ross","year":"2003","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.nut.2013.11.001_bib44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12311-009-0105-9","article-title":"Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism","volume":"8","author":"Sajdel-Sulkowska","year":"2009","journal-title":"Cerebellum"},{"key":"10.1016\/j.nut.2013.11.001_bib45","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.lfs.2004.04.038","article-title":"Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin\u2014the antioxidant proteins","volume":"75","author":"Chauhan","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.nut.2013.11.001_bib46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1054\/plef.2002.0439","article-title":"Investigation of antioxidant enzymes in children with autistic disorder","volume":"67","author":"Yorbik","year":"2002","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.nut.2013.11.001_bib47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00406-004-0456-7","article-title":"Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism","volume":"254","author":"Zoroglu","year":"2004","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.nut.2013.11.001_bib48","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.freeradbiomed.2013.07.021","article-title":"Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: alterations in the activities and protein expression of glutathione-related enzymes","volume":"65","author":"Gu","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nut.2013.11.001_bib49","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.freeradbiomed.2012.03.011","article-title":"Oxidative stress-related biomarkers in autism: systematic review and meta-analyses","volume":"52","author":"Frustaci","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nut.2013.11.001_bib50","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s11064-012-0775-4","article-title":"Brain region-specific glutathione redox imbalance in autism","volume":"37","author":"Chauhan","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.nut.2013.11.001_bib51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000343106","article-title":"A history of vitamin E","volume":"61","author":"Niki","year":"2012","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nut.2013.11.001_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0891-5849(89)90117-2","article-title":"Vitamin E and neurologic function in man","volume":"6","author":"Sokol","year":"1989","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.nut.2013.11.001_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng0295-141","article-title":"Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein","volume":"9","author":"Ouahchi","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.nut.2013.11.001_bib54","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1194\/jlr.M600514-JLR200","article-title":"Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase","volume":"48","author":"Sontag","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nut.2013.11.001_bib55","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3945\/jn.111.151902","article-title":"Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients","volume":"142","author":"Patel","year":"2012","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2891-12-2","article-title":"Perturbation of cellular immune functions in cigarette smokers and protection by palm oil vitamin E supplementation","volume":"12","author":"Jubri","year":"2013","journal-title":"Nutr J"},{"key":"10.1016\/j.nut.2013.11.001_bib57","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.arr.2011.06.006","article-title":"Do tocotrienols have potential as neuroprotective dietary factors?","volume":"11","author":"Frank","year":"2012","journal-title":"Ageing Res Rev"},{"issue":"Suppl","key":"10.1016\/j.nut.2013.11.001_bib58","doi-asserted-by":"crossref","first-page":"314S","DOI":"10.1080\/07315724.2010.10719846","article-title":"Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease","volume":"29","author":"Sen","year":"2010","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib59","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1021\/bi00091a020","article-title":"Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency","volume":"32","author":"Suzuki","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.nut.2013.11.001_bib60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0891-5849(91)90033-Y","article-title":"Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol","volume":"10","author":"Serbinova","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nut.2013.11.001_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1743-7075-8-42","article-title":"Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: a randomized controlled study","volume":"8","author":"Chin","year":"2011","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.nut.2013.11.001_bib62","doi-asserted-by":"crossref","first-page":"43508","DOI":"10.1074\/jbc.M307075200","article-title":"Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration","volume":"278","author":"Khanna","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2013.11.001_bib63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1196\/annals.1331.013","article-title":"Tocotrienol: the natural vitamin E to defend the nervous system?","volume":"1031","author":"Sen","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.nut.2013.11.001_bib64","doi-asserted-by":"crossref","first-page":"13049","DOI":"10.1074\/jbc.275.17.13049","article-title":"Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells","volume":"275","author":"Sen","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2013.11.001_bib65","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2202-14-77","article-title":"The effects of prenatal and early postnatal tocotrienol-rich fraction supplementation on cognitive function development in male offspring rats","volume":"14","author":"Nagapan","year":"2013","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.nut.2013.11.001_bib66","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1161\/STROKEAHA.110.608547","article-title":"Natural vitamin E \u03b1-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1","volume":"42","author":"Park","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.nut.2013.11.001_bib67","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1038\/jcbfm.2011.85","article-title":"Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis","volume":"31","author":"Rink","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.nut.2013.11.001_bib68","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1089\/ars.2007.1874","article-title":"Can the therapeutic efficacy of tocotrienols in neurodegenerative familial dysautonomia patients be measured clinically?","volume":"10","author":"Rubin","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.nut.2013.11.001_bib69","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/ALN.0b013e318267084d","article-title":"Case scenario: perioperative administration of tocotrienols and green tea extract in a child with familial dysautonomia","volume":"117","author":"Cook-Sather","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nut.2013.11.001_bib70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10284150400027123","article-title":"Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties","volume":"8","author":"Rota","year":"2005","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.nut.2013.11.001_bib71","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pharmthera.2010.03.001","article-title":"Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics","volume":"127","author":"Sun","year":"2010","journal-title":"Pharmacol Ther"},{"issue":"Suppl","key":"10.1016\/j.nut.2013.11.001_bib72","doi-asserted-by":"crossref","first-page":"334S","DOI":"10.1080\/07315724.2010.10719848","article-title":"Role of NF-kappaB in the anti-inflammatory effects of tocotrienols","volume":"29","author":"Kaileh","year":"2010","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib73","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.4049\/jimmunol.1002342","article-title":"Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively","volume":"86","author":"Jiang","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2013.11.001_bib74","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1476-511X-11-160","article-title":"Lipid mediators in plasma of autism spectrum disorders","volume":"11","author":"El-Ansary","year":"2012","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nut.2013.11.001_bib75","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ajcn\/52.3.557","article-title":"Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects","volume":"52","author":"Meydani","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib76","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0929-7855(94)00032-8","article-title":"Modulation of the endogenous leukotriene production by fish oil and vitamin E","volume":"11","author":"Denzlinger","year":"1995","journal-title":"J Lipid Mediat Cell Signal"},{"key":"10.1016\/j.nut.2013.11.001_bib77","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/ajcn\/64.6.960","article-title":"Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults","volume":"64","author":"Jeng","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2013.11.001_bib78","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1017\/S0007114508039998","article-title":"Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers","volume":"101","author":"Radhakrishnan","year":"2009","journal-title":"Br J Nutr"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900713005030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900713005030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T20:54:16Z","timestamp":1564692856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900713005030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":78,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0899900713005030"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2013.11.001","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can \u03c9-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders?","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2013.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}