{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:02Z","timestamp":1791214502249,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["nutritionjrnl.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.nut.2013.11.012","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T22:09:47Z","timestamp":1386194987000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of the anticatabolic effects of leucine and Ca-\u03b2-hydroxy-\u03b2-methylbutyrate in experimental models of cancer cachexia"],"prefix":"10.1016","volume":"30","author":[{"given":"Kamran A.","family":"Mirza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette L.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Tisdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2013.11.012_bib1","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.biocel.2004.10.017","article-title":"Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss","volume":"37","author":"Khal","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.nut.2013.11.012_bib2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/bmj.289.6445.584","article-title":"Protein synthesis in muscle measured in\u00a0vivo in cachectic patients with cancer","volume":"289","author":"Emery","year":"1984","journal-title":"Br Med J"},{"key":"10.1016\/j.nut.2013.11.012_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcp.10097","article-title":"Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?","volume":"19","author":"Busquets","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nut.2013.11.012_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1158\/0008-5472.277.65.1","article-title":"Attenuation of proteasome-induced proteolysis in skeletal muscle by \u03b2-hydroxy-\u03b2-methylbutyrate in cancer-induced muscle loss","volume":"65","author":"Smith","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.nut.2013.11.012_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0002-9610(02)00823-1","article-title":"Reversal of cancer-related wasting using oral supplementation with a combination of \u03b2-hydroxy-\u03b2-methylbutyrate, arginine and glutamine","volume":"183","author":"May","year":"2002","journal-title":"Am J Surg"},{"key":"10.1016\/j.nut.2013.11.012_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20070651","article-title":"Effect of branched-chain amino acids on muscle atrophy in cancer cachexia","volume":"407","author":"Eley","year":"2007","journal-title":"Biochem J"},{"key":"10.1016\/j.nut.2013.11.012_bib7","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1074\/jbc.M610378200","article-title":"Skeletal muscle atrophy: a link between depression of protein synthesis and increase in degradation","volume":"282","author":"Eley","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2013.11.012_bib8","doi-asserted-by":"crossref","first-page":"E923","DOI":"10.1152\/ajpendo.00314.2007","article-title":"Signaling pathways initiated \u03b2-hydroxy-\u03b2-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli","volume":"293","author":"Eley","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2013.11.012_bib9","doi-asserted-by":"crossref","first-page":"E1409","DOI":"10.1152\/ajpendo.90530.2008","article-title":"Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by \u03b2-hydroxy-\u03b2-methylbutyrate","volume":"295","author":"Eley","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2013.11.012_bib10","doi-asserted-by":"crossref","first-page":"E1417","DOI":"10.1152\/ajpendo.90567.2008","article-title":"Mechanism of attenuation of muscle protein degradation induced by lipopolysaccharide, tumor necrosis factor-\u03b1 and angiotensin II by \u03b2-hydroxy-\u03b2-methylbutyrate","volume":"295","author":"Eley","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2013.11.012_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/bjc.2011.216","article-title":"Attenuation of muscle atrophy by an n-terminal peptide of the receptor for proteolysis-inducing factor (PIF)","volume":"105","author":"Mirza","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.nut.2013.11.012_bib12","first-page":"539","article-title":"Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals","volume":"78","author":"Bibby","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.nut.2013.11.012_bib13","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1158\/0008-5472.CAN-04-1760","article-title":"Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in skeletal muscle by \u03b2-hydroxy-\u03b2-methylbutyrate","volume":"64","author":"Smith","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.nut.2013.11.012_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1998.1","article-title":"United Kingdom Co-ordinating Committee on Cancer Research (UKCCR). Guidelines for the welfare of animals with experimental neoplasia (2nd ed.)","volume":"77","author":"Workman","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.nut.2013.11.012_bib15","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/sj.bjc.6601132","article-title":"Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-\u03baB","volume":"89","author":"Whitehouse","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.nut.2013.11.012_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"IKKbeta\/NF-kappaB activation causes severe muscle wasting in mice","volume":"119","author":"Cai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.nut.2013.11.012_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.nut.2013.11.012_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1744-1161(12)70015-7","article-title":"Inhibition of FOXO transcriptional activity by \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) prevents glucocorticoid-induced muscle fiber atrophy","volume":"7","author":"L\u00f3pez-Pedrosa","year":"2012","journal-title":"Clin Nutr Suppl"},{"key":"10.1016\/j.nut.2013.11.012_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/bjc.1993.126","article-title":"Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia","volume":"67","author":"Smith","year":"1993","journal-title":"Br J Cancer"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900713005406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900713005406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T17:54:43Z","timestamp":1688838883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900713005406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":19,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0899900713005406"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2013.11.012","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the anticatabolic effects of leucine and Ca-\u03b2-hydroxy-\u03b2-methylbutyrate in experimental models of cancer cachexia","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2013.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}