{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:10:35Z","timestamp":1767996635140,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["patient-research.elsevier.com","nutritionjrnl.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.nut.2014.01.013","type":"journal-article","created":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T09:46:36Z","timestamp":1392457596000},"page":"1076-1080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats"],"prefix":"10.1016","volume":"30","author":[{"given":"Xing","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufen","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Qiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2014.01.013_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/ejcn.2011.62","article-title":"Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies","volume":"65","author":"Tong","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3945\/jn.110.133736","article-title":"Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet","volume":"141","author":"Shertzer","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1017\/S0007114510000991","article-title":"Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals","volume":"104","author":"Pal","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcn\/82.1.69","article-title":"Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects","volume":"82","author":"Frid","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/jn\/134.6.1454","article-title":"A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in wistar rats","volume":"134","author":"Belobrajdic","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00726-013-1488-y","article-title":"An amino acid mixture improves glucose tolerance and lowers insulin resistance in the obese Zucker rat","volume":"45","author":"Bernard","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.nut.2014.01.013_bib7","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jnutbio.2012.10.004","article-title":"Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats","volume":"24","author":"Eller","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2014.01.013_bib8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2337\/db07-0123","article-title":"Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms","volume":"56","author":"Zhang","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.nut.2014.01.013_bib9","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1002\/jssc.200800363","article-title":"Revisitation of the phenylisothiocyanatederivatives procedure for amino acid determination by HPLC-UV","volume":"31","author":"Checa-Moreno","year":"2008","journal-title":"J Sep Sci"},{"key":"10.1016\/j.nut.2014.01.013_bib10","doi-asserted-by":"crossref","first-page":"E1231","DOI":"10.1152\/ajpendo.00173.2001","article-title":"Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats","volume":"282","author":"Chalkley","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2014.01.013_bib11","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jnutbio.2011.10.005","article-title":"Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice","volume":"23","author":"Freudenberg","year":"2012","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2014.01.013_bib12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00394-010-0155-2","article-title":"Body weight and energy homeostasis was not affected in C57BL\/6 mice fed high whey protein or leucine-supplemented low-fat diets","volume":"50","author":"Noatsch","year":"2011","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3945\/jn.110.128520","article-title":"Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults","volume":"141","author":"Qin","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib14","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/mnfr.201200311","article-title":"Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues","volume":"57","author":"Li","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.nut.2014.01.013_bib15","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3945\/jn.113.174912","article-title":"A whey protein hydrolysate promotes insulinotropic activity in a clonal pancreatic \u03b2-cell line and enhances glycemic function in ob\/ob mice","volume":"143","author":"Gaudel","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib16","doi-asserted-by":"crossref","first-page":"e71134","DOI":"10.1371\/journal.pone.0071134","article-title":"Whey protein hydrolysate increases translocation of GLUT-4 to the plasma membrane independent of insulin in wistar rats","volume":"8","author":"Morato","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2014.01.013_bib17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/ajcn\/85.4.996","article-title":"Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks","volume":"85","author":"Nilsson","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2014.01.013_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.00024.2006","article-title":"Disordered lipid metabolism and the pathogenesis of insulin resistance","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nut.2014.01.013_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-7075-8-62","article-title":"Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet","volume":"8","author":"Torres-Leal","year":"2011","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.nut.2014.01.013_bib20","doi-asserted-by":"crossref","first-page":"17787","DOI":"10.1073\/pnas.0902380106","article-title":"Insulin resistance is a cellular antioxidant defense mechanism","volume":"106","author":"Hoehn","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nut.2014.01.013_bib21","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.3168\/jds.2010-3891","article-title":"Antioxidative effects of whey protein on peroxide-induced cytotoxicity","volume":"94","author":"Xu","year":"2011","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.nut.2014.01.013_bib22","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s10529-012-1017-1","article-title":"Protective effect of whey protein hydrolysates against hydrogen peroxide-induced oxidative stress on PC12 cells","volume":"34","author":"Zhang","year":"2012","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.nut.2014.01.013_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3177\/jnsv.59.198","article-title":"Whey protein inhibits iron overload-induced oxidative stress in rats","volume":"59","author":"Kim","year":"2013","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.nut.2014.01.013_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/1476-511X-11-67","article-title":"Dietary whey protein lessens several risk factors for metabolic diseases: a review","author":"Sousa","year":"2012","journal-title":"Lipids Health Dis"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T17:14:21Z","timestamp":1565198061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900714000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0899900714000793"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2014.01.013","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2014.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}