{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:16Z","timestamp":1760122336114,"version":"3.40.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["patient-research.elsevier.com","nutritionjrnl.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.nut.2014.02.008","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T10:15:44Z","timestamp":1393582544000},"page":"S37-S42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"S","title":["St. John\u2019s Wort enhances the synaptic activity of the nucleus of the solitary tract"],"prefix":"10.1016","volume":"30","author":[{"given":"Katie M.","family":"Vance","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Ribnicky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinda E.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2014.02.008_bib1","series-title":"Physiology of the gastrointestinal tract","first-page":"861","article-title":"Brainstem control of gastric function","author":"Rogers","year":"2012"},{"key":"10.1016\/j.nut.2014.02.008_bib2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0022-3565(25)22847-6","article-title":"Is l-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius","volume":"250","author":"Leone","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nut.2014.02.008_bib3","doi-asserted-by":"crossref","first-page":"R1065","DOI":"10.1152\/ajpregu.1994.267.4.R1065","article-title":"Both nmda and non-nmda receptors in the nts participate in the baroreceptor reflex in rats","volume":"267","author":"Ohta","year":"1994","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.nut.2014.02.008_bib4","doi-asserted-by":"crossref","first-page":"H1236","DOI":"10.1152\/ajpheart.1998.275.4.H1236","article-title":"Non-nmda and nmda receptors in the synaptic pathway between area postrema and nucleus tractus solitarius","volume":"275","author":"Aylwin","year":"1998","journal-title":"Am J Physiol-Heart Circul Physiol"},{"year":"1997","author":"Blessing","series-title":"The lower brainstem and body homeostasis","key":"10.1016\/j.nut.2014.02.008_bib5"},{"key":"10.1016\/j.nut.2014.02.008_bib6","article-title":"Tumor necrosis factor (tnf) positively modulates vagal afferent excitability within the solitary nucleus: An in\u00a0vitro live-cell imaging study","volume":"130","author":"Rogers","year":"2006","journal-title":"Gastroenterology"},{"year":"2008","author":"Barnes","series-title":"Complementary and alternative medicine use among adults and children: United States, 2007. National health statistics reports; no 12","key":"10.1016\/j.nut.2014.02.008_bib7"},{"key":"10.1016\/j.nut.2014.02.008_bib8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2165\/00023210-200317080-00001","article-title":"Mechanism of action of St John\u2019s wort in depression\u2014what is known?","volume":"17","author":"Butterweck","year":"2003","journal-title":"CNS Drugs"},{"key":"10.1016\/j.nut.2014.02.008_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1211\/0022357011775910","article-title":"St John\u2019s wort (hypericum perforatum l.): a review of its chemistry, pharmacology and clinical properties","volume":"53","author":"Barnes","year":"2001","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.nut.2014.02.008_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1043-6618(02)00266-9","article-title":"Current St. John\u2019s wort research from mode of action to clinical efficacy","volume":"47","author":"Muller","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.nut.2014.02.008_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0304-3940(99)00087-7","article-title":"Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus","volume":"262","author":"Kaehler","year":"1999","journal-title":"Neurosci Let"},{"key":"10.1016\/j.nut.2014.02.008_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0006-8993(98)01126-3","article-title":"Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes","volume":"816","author":"Neary","year":"1999","journal-title":"Brain Research"},{"key":"10.1016\/j.nut.2014.02.008_bib13","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1055\/s-2001-15465","article-title":"Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John\u2019s wort","volume":"34","author":"Wonnemann","year":"2001","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.nut.2014.02.008_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1055\/s-2007-979528","article-title":"Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity","volume":"30","author":"M\u00fcller","year":"1997","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.nut.2014.02.008_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2007-979530","article-title":"Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 a and 5-HT2 a receptors","volume":"30","author":"TeufelMayer","year":"1997","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.nut.2014.02.008_bib16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1078\/0944-7113-00340","article-title":"A review of clinical and experimental observations about antidepressant actions and side effects produced by hypericum perforatum extracts","volume":"10","author":"Rodriguez-Landa","year":"2003","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nut.2014.02.008_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/pauz.200390067","article-title":"What is known about St. John\u2019s wort? Phytochemistry and pharmacology","volume":"32","author":"Butterweck","year":"2003","journal-title":"Pharmazie in unserer Zeit"},{"key":"10.1016\/j.nut.2014.02.008_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0024-3205(98)00299-9","article-title":"Hyperforin as a possible antidepressant component of hypericum extracts","volume":"63","author":"Chatterjee","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.nut.2014.02.008_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1211\/0022357991772132","article-title":"Isolation, purity analysis and stability of hyperforin as a standard material from hypericum perforatum L","volume":"51","author":"Orth","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.nut.2014.02.008_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02575285","article-title":"HPLC-DAD and TLC-densitometry for quantification of hypericin in hypericum perforatum L. extracts","volume":"49","author":"Mulinacci","year":"1999","journal-title":"Chromatographia"},{"key":"10.1016\/j.nut.2014.02.008_bib21","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1096\/fj.07-8110com","article-title":"Hyperforin\u2014a key constituent of St. John\u2019s wort specifically activates TRPC6 channels","volume":"21","author":"Leuner","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2014.02.008_bib22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/hipo.22052","article-title":"Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+)- permeable TRPC6 channels","volume":"23","author":"Leuner","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.nut.2014.02.008_bib23","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/S0024-3205(02)02104-5","article-title":"The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin","volume":"71","author":"Marsh","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.nut.2014.02.008_bib24","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0022-3565(24)35043-8","article-title":"Hyperforin, a major antidepressant constituent ofst. John's wort, inhibits serotonin uptake by elevating free intracellular Na+","volume":"290","author":"Singer","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nut.2014.02.008_bib25","doi-asserted-by":"crossref","first-page":"12642","DOI":"10.1523\/JNEUROSCI.3530-06.2006","article-title":"Tumor necrosis factor potentiates central vagal afferent signaling by modulating ryanodine channels","volume":"26","author":"Rogers","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.nut.2014.02.008_bib26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nmeth.1668","article-title":"Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function","volume":"8","author":"Zhao","year":"2011","journal-title":"Nat Methods"},{"key":"10.1016\/j.nut.2014.02.008_bib27","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1523\/JNEUROSCI.6220-11.2012","article-title":"Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids","volume":"32","author":"Rogers","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.nut.2014.02.008_bib28","doi-asserted-by":"crossref","first-page":"11011","DOI":"10.1523\/JNEUROSCI.2519-09.2009","article-title":"Robust pacemaking in substantia nigra dopaminergic neurons","volume":"29","author":"Guzman","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.nut.2014.02.008_bib29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbrc.2009.07.137","article-title":"St. John\u2019s wort inhibits adipocyte differentiation and induces insulin resistance in adipocytes","volume":"388","author":"Amini","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nut.2014.02.008_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1113\/jphysiol.2007.130377","article-title":"Astrocytic control of synaptic NMDA receptors","volume":"581","author":"Lee","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.nut.2014.02.008_bib31","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.0753-04.2004","article-title":"Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius","volume":"24","author":"Jin","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.nut.2014.02.008_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneumeth.2005.05.020","article-title":"Live-cell imaging methods for the study of vagal afferents within the nucleus of the solitary tract","volume":"150","author":"Rogers","year":"2006","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.nut.2014.02.008_bib33","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.nut.2014.02.008_bib34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S1359-6446(05)03398-2","article-title":"Strategies for producing faster acting antidepressants","volume":"10","author":"Adell","year":"2005","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.nut.2014.02.008_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1176\/appi.ajp.163.1.5","article-title":"Beyond efficacy: the STAR*D trial","volume":"163","author":"Insel","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.nut.2014.02.008_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice","volume":"163","author":"Trivedi","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.nut.2014.02.008_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/026988110101500109","article-title":"Hypericum perforatum (St John\u2019 wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology","volume":"15","author":"Nathan","year":"2001","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.nut.2014.02.008_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-3565(24)39043-3","article-title":"Inhibition of human cytochrome P450 enzymes by constituents of St. John\u2019s wort, an herbal preparation used in the treatment of depression","volume":"294","author":"Obach","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nut.2014.02.008_bib39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1067\/mcp.2000.106793","article-title":"St John\u2019s wort: effect on CYP3 A4 activity","volume":"67","author":"Roby","year":"2000","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.nut.2014.02.008_bib40","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1053\/cp.1999.v66.a101944","article-title":"Pharmacokinetic interaction of digoxin with an herbal extract from St John\u2019s wort (Hypericum perforatum)","volume":"66","author":"Johne","year":"1999","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.nut.2014.02.008_bib41","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1073\/pnas.130155097","article-title":"St. John\u2019s wort induces hepatic drug metabolism through activation of the pregnane X receptor","volume":"97","author":"Moore","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nut.2014.02.008_bib42","first-page":"308","article-title":"Evaluation of the benefits and risks of the hypericum extract LI-160 based on a drug-monitoring study with 3250 patients","volume":"12","author":"Woelk","year":"1993","journal-title":"Nervenheilkunde"},{"key":"10.1016\/j.nut.2014.02.008_bib43","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.2000.279.3.G582","article-title":"TNF-alpha activates solitary nucleus neurons responsive to gastric distension","volume":"279","author":"Emch","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.nut.2014.02.008_bib44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2003.11.078","article-title":"TNF alpha-P55 receptors: medullary brainstem immunocytochemical localization in normal and vagus nerve-transected rats","volume":"1004","author":"Hermann","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.nut.2014.02.008_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1053\/j.gastro.2004.11.062","article-title":"Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons","volume":"128","author":"Page","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nut.2014.02.008_bib46","first-page":"74","article-title":"Tumor-necrosis-factor-alpha in the dorsal vagal\u00a0complex suppresses gastric-motility","volume":"2","author":"Hermann","year":"1995","journal-title":"Neuromodulation"},{"key":"10.1016\/j.nut.2014.02.008_bib47","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1523\/JNEUROSCI.22-18-08222.2002","article-title":"Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius","volume":"22","author":"Doyle","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.nut.2014.02.008_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneumeth.2004.02.007","article-title":"Strategies for cellular identification in nucleus tractus solitarius slices","volume":"137","author":"Doyle","year":"2004","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.nut.2014.02.008_bib49","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2174\/1381612053507828","article-title":"TNF alpha modulation of visceral\u00a0and spinal sensory processing","volume":"11","author":"Hermann","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.nut.2014.02.008_bib50","doi-asserted-by":"crossref","first-page":"G634","DOI":"10.1152\/ajpgi.00412.2001","article-title":"Lps-induced suppression of gastric motility relieved by TNFR: Fc construct in dorsal vagal complex","volume":"283","author":"Hermann","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714000938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714000938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T23:27:12Z","timestamp":1746142032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900714000938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":50,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0899900714000938"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2014.02.008","relation":{},"ISSN":["0899-9007"],"issn-type":[{"type":"print","value":"0899-9007"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"St. John\u2019s Wort enhances the synaptic activity of the nucleus of the solitary tract","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2014.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}