{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:01:42Z","timestamp":1788926502090,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","nutritionjrnl.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.nut.2014.11.016","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T11:07:50Z","timestamp":1419073670000},"page":"813-819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Maternal vitamin A supplementation increases natural antibody concentrations of preadolescent offspring in rural Nepal"],"prefix":"10.1016","volume":"31","author":[{"given":"Amanda C.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subarna K.","family":"Khatry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi M.","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Keith P.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2014.11.016_bib1","series-title":"Global prevalence of vitamin A deficiency in populations at risk 1995 to 2005. WHO Global Database on Vitamin A Deficiency","first-page":"116","author":"World Health Organization","year":"2009"},{"key":"10.1016\/j.nut.2014.11.016_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.nutr.21.1.167","article-title":"Vitamin A, infection, and immune function","volume":"21","author":"Stephensen","year":"2001","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/tropej\/44.4.232","article-title":"Maternal vitamin A deficiency and infant mortality in Malawi","volume":"44","author":"Semba","year":"1998","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.nut.2014.11.016_bib4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/jn\/131.5.1510","article-title":"Maternal night blindness increases risk of mortality in the first 6 mo of life among infants in Nepal","volume":"131","author":"Christian","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/ajcn\/71.6.1570","article-title":"Maternal low-dose vitamin A or beta-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal","volume":"71","author":"Katz","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3945\/an.111.000570","article-title":"Nutritionally mediated programming of the developing immune system","volume":"2","author":"Palmer","year":"2011","journal-title":"Adv Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2011.11.017","article-title":"B-1 B cell development in the fetus and adult","volume":"36","author":"Montecino-Rodriguez","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.nut.2014.11.016_bib8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00281-004-0182-2","article-title":"Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion","volume":"26","author":"Baumgarth","year":"2005","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.nut.2014.11.016_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4049\/jimmunol.155.1.58","article-title":"All-trans- and 9-cis-retinoic acid inhibit growth of normal human and murine B cell precursors","volume":"155","author":"Fahlman","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib10","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1002\/eji.200939374","article-title":"A possible contribution of retinoids to regulation of fetal B lymphopoiesis","volume":"39","author":"Chen","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/bmj.318.7183.570","article-title":"Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group","volume":"318","author":"West","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.nut.2014.11.016_bib12","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ajcn\/67.6.1237","article-title":"Hyporetinolemia, illness symptoms, and acute phase protein response in pregnant women with and without night blindness","volume":"67","author":"Christian","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib13","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJM199805073381906","article-title":"Antibodies to DNA","volume":"338","author":"Hahn","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nut.2014.11.016_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s002960050063","article-title":"IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. SLE Study Group","volume":"18","author":"Witte","year":"1998","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.nut.2014.11.016_bib15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1172\/JCI29943","article-title":"Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics","volume":"117","author":"Merbl","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2014.11.016_bib16","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1017\/S0007114507839614","article-title":"Lifestyle-related determinants of inflammation in adolescence","volume":"98","author":"W\u00e4rnberg","year":"2007","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.pu.14.050193.000355","article-title":"Regression analysis for correlated data","volume":"14","author":"Liang","year":"1993","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.nut.2014.11.016_bib18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1086\/506457","article-title":"Neonatal vitamin a supplementation: sex-differential effects on mortality?","volume":"194","author":"Benn","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nut.2014.11.016_bib19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/ije\/dyg208","article-title":"Hypothesis: vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines?","volume":"32","author":"Benn","year":"2003","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.nut.2014.11.016_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nri2019","article-title":"Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential","volume":"7","author":"Dorshkind","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib21","first-page":"154","article-title":"Natural autoantibodies: from \u201chorror autotoxicus\u201d to \u201cgnothi seauton\u201d","volume":"12","author":"Avrameas","year":"1991","journal-title":"Immunol Today"},{"key":"10.1016\/j.nut.2014.11.016_bib22","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/0952-7915(95)80053-0","article-title":"Natural autoantibodies","volume":"7","author":"Coutinho","year":"1995","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib23","first-page":"167","article-title":"Structure and function of natural antibodies","volume":"210","author":"Casali","year":"1996","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/ajcn\/49.3.501","article-title":"Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III)","volume":"49","author":"Pasatiempo","year":"1989","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2014.11.016_bib25","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1096\/fasebj.4.8.2110538","article-title":"Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens","volume":"4","author":"Pasatiempo","year":"1990","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2014.11.016_bib26","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.exphem.2005.06.007","article-title":"Regulation of hematopoiesis by retinoid signaling","volume":"33","author":"Evans","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.nut.2014.11.016_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.180.1.138","article-title":"Retinoids accelerate B lineage lymphoid differentiation","volume":"180","author":"Chen","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib28","doi-asserted-by":"crossref","first-page":"b919","DOI":"10.1136\/bmj.b919","article-title":"Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials","volume":"338","author":"Gogia","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.nut.2014.11.016_bib29","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1016\/j.vaccine.2008.04.021","article-title":"Conflicting evidence for neonatal vitamin A supplementation","volume":"26","author":"Benn","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.nut.2014.11.016_bib30","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1136\/bmj.39575.486609.80","article-title":"Vitamin A supplements in newborns and child survival","volume":"336","author":"Tielsch","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.nut.2014.11.016_bib31","doi-asserted-by":"crossref","first-page":"c1101","DOI":"10.1136\/bmj.c1101","article-title":"Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial","volume":"340","author":"Benn","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.nut.2014.11.016_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.0105-2896.2004.0109.x","article-title":"Peripheral development of B cells in mouse and man","volume":"197","author":"Carsetti","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.nut.2014.11.016_bib33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nbt.2009.03.016","article-title":"Natural antibodies and cancer","volume":"25","author":"Vollmers","year":"2009","journal-title":"N Biotechnol"},{"key":"10.1016\/j.nut.2014.11.016_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2796.2008.01968.x","article-title":"Oxidation-specific epitopes are important targets of innate immunity","volume":"263","author":"Chou","year":"2008","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.nut.2014.11.016_bib35","first-page":"415","article-title":"B-1 cell immunoglobulin directed against oxidation-specific epitopes","volume":"3","author":"Tsiantoulas","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/STROKEAHA.109.558742","article-title":"Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden","volume":"41","author":"Fiskesund","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.nut.2014.11.016_bib37","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/eji.201040545","article-title":"Immunoglobulin secretion by B1 cells: differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells","volume":"40","author":"Holodick","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12016-007-8046-x","article-title":"IgM antibodies against dsDNA in SLE","volume":"34","author":"Witte","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.nut.2014.11.016_bib39","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1126\/science.1196509","article-title":"Fetal and adult hematopoietic stem cells give rise\u00a0to\u00a0distinct T cell lineages in humans","volume":"330","author":"Mold","year":"2010","journal-title":"Science"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714005164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900714005164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T20:43:33Z","timestamp":1690749813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900714005164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0899900714005164"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2014.11.016","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal vitamin A supplementation increases natural antibody concentrations of preadolescent offspring in rural Nepal","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2014.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}