{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:55:34Z","timestamp":1778075734806,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","nutritionjrnl.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.nut.2016.01.010","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T22:00:52Z","timestamp":1453413652000},"page":"849-854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats"],"prefix":"10.1016","volume":"32","author":[{"given":"Nahla E.","family":"El-Ashmawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman G.","family":"Khedr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda A.","family":"El-Bahrawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend M.","family":"Selim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2016.01.010_bib1","doi-asserted-by":"crossref","first-page":"125649","DOI":"10.1155\/2013\/125649","article-title":"Role of garlic usage in cardiovascular disease prevention: An evidence-based approach","volume":"2013","author":"Qidwai","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nut.2016.01.010_bib2","first-page":"119","article-title":"Mechanisms of antiulcerogenic effect of garlic (Allium sativum) in albino rats","volume":"8","author":"Tope","year":"2013","journal-title":"Int J Trop Med"},{"key":"10.1016\/j.nut.2016.01.010_bib3","doi-asserted-by":"crossref","first-page":"S713","DOI":"10.1093\/jn\/136.3.713S","article-title":"Is garlic alternative medicine?","volume":"136","author":"Rivlin","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2016.01.010_bib4","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1089\/jmf.2012.2275","article-title":"Antiinflammatory activity of sulfur-containing compounds from garlic","volume":"15","author":"Lee da","year":"2012","journal-title":"J Med Food"},{"key":"10.1016\/j.nut.2016.01.010_bib5","doi-asserted-by":"crossref","first-page":"759642","DOI":"10.1155\/2014\/759642","article-title":"The protective effect of aged garlic extract on nonsteroidal antiinflammatory drug-induced gastric inflammations in male albino rats","volume":"2014","author":"Badr","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nut.2016.01.010_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/546560","article-title":"Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative reaction","volume":"2011","author":"Adhikary","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nut.2016.01.010_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10753-009-9176-5","article-title":"Different mechanisms in formation and prevention of indomethacin-inducd gastric ulcers","volume":"33","author":"Suleyman","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.nut.2016.01.010_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13105-013-0241-z","article-title":"Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats","volume":"69","author":"Abbas","year":"2013","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.nut.2016.01.010_bib9","doi-asserted-by":"crossref","first-page":"596920","DOI":"10.1155\/2014\/596920","article-title":"Protective effect of Flos lonicerae against experimental gastric ulcers in rats: Mechanisms of antioxidant and antiinflammatory action","volume":"2014","author":"Kang","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nut.2016.01.010_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.etp.2010.09.007","article-title":"Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats","volume":"64","author":"Izzettin","year":"2012","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.nut.2016.01.010_bib11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1590\/S0102-695X2011005000117","article-title":"Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats","volume":"21","author":"Araujo","year":"2011","journal-title":"Rev Braz Farmacogn"},{"key":"10.1016\/j.nut.2016.01.010_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/142719","article-title":"Cytoprotective effect of Morinda tinctoria Roxb. against surgical and chemical factor induced gastric and duodenal ulcers in rats","volume":"2011","author":"Sivaraman","year":"2011","journal-title":"Ulcers"},{"key":"10.1016\/j.nut.2016.01.010_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.19026\/crjbs.6.5495","article-title":"Effect of vitamins C & E on aspirin induced gastric mucosal damage and oxidative stress","volume":"6","author":"Dawud","year":"2014","journal-title":"Curr Res J Biol Sci"},{"key":"10.1016\/j.nut.2016.01.010_bib14","first-page":"37","article-title":"The effect of neuroleptics on the development of gastric ulcers in rats exposed to restraint-cold stress","volume":"28","author":"Hano","year":"1976","journal-title":"Pol J Pharmacol Pharm"},{"key":"10.1016\/j.nut.2016.01.010_bib15","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.nut.2016.01.010_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"Satoh","year":"1978","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.nut.2016.01.010_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.nut.2016.01.010_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.nut.2016.01.010_bib19","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1742-7843.2010.00568.x","article-title":"Gastroprotective effect of rutin against indomethacin-induced ulcers in rats","volume":"107","author":"Abdel-Raheem","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.nut.2016.01.010_bib20","first-page":"433","article-title":"Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats","volume":"8","author":"Abdallah","year":"2011","journal-title":"Life Sci J"},{"key":"10.1016\/j.nut.2016.01.010_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/2229-516X.149238","article-title":"Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in wistar albino rats","volume":"5","author":"Oluwabunmi","year":"2015","journal-title":"Int J Appl Basic Med Res"},{"key":"10.1016\/j.nut.2016.01.010_bib22","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.bcp.2006.02.009","article-title":"Molecular targets of dietary agents for prevention and therapy of cancer","volume":"71","author":"Aggarwal","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nut.2016.01.010_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/18715206113136660370","article-title":"The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention","volume":"14","author":"Sch\u00e4fer","year":"2014","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.nut.2016.01.010_bib24","first-page":"344","article-title":"Involvement of inflammatory mediators in the gastroprotective action of Phaleria macrocarpa against ethanol-induced gastric ulcer","volume":"30","author":"Abood","year":"2014","journal-title":"World Appl Sci J"},{"key":"10.1016\/j.nut.2016.01.010_bib25","doi-asserted-by":"crossref","first-page":"907162","DOI":"10.1155\/2012\/907162","article-title":"The antioxidant mechanisms underlying the aged garlic extract and S-allylcesteine-induced protection","volume":"2012","author":"Col\u00edn-Gonz\u00e1lez","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.nut.2016.01.010_bib26","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1074\/jbc.M210328200","article-title":"A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical","volume":"278","author":"Biswas","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2016.01.010_bib27","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4236\/fns.2011.26088","article-title":"Comparative evaluation of anti-ulcer activity of curcumin and omeprazole during the acute phase of gastric ulcer","volume":"2","author":"Abdul-Aziz","year":"2011","journal-title":"Food Nut Sci"},{"key":"10.1016\/j.nut.2016.01.010_bib28","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2036.2009.04086.x","article-title":"Review article: Cellular and molecular mechanisms of NSAID-induced peptic ulcers","volume":"30","author":"Musumba","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nut.2016.01.010_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.niox.2012.06.001","article-title":"Protective effects of nebivolol against cold restraint stress induced gastric ulcer in rats: Role of NO, HO-1 and COX-1,2","volume":"27","author":"Morsy","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.nut.2016.01.010_bib30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2174\/1381612013397645","article-title":"New issues about nitric oxide and its effects on the gastrointestinal tract","volume":"7","author":"Mart\u00edn","year":"2001","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.nut.2016.01.010_bib31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jep.2012.10.045","article-title":"Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation","volume":"145","author":"Weiss","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.nut.2016.01.010_bib32","doi-asserted-by":"crossref","first-page":"S777","DOI":"10.1093\/jn\/136.3.777S","article-title":"Aged garlic extract maintains cardiovascular homeostasis in mice and rats","volume":"136","author":"Morihara","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2016.01.010_bib33","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.1440-1681.2000.03333.x","article-title":"Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats","volume":"27","author":"Kim-Park","year":"2000","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.nut.2016.01.010_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1440-1681.2002.03596.x","article-title":"Garlic and its active metabolite allicin produce endothelium and nitric oxide dependent relaxation in rat pulmonary arteries","volume":"29","author":"Ku","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.nut.2016.01.010_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1124\/pr.57.2.1","article-title":"Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors","volume":"57","author":"Mollace","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.nut.2016.01.010_bib36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2009.02.008","article-title":"Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: Role of nitric oxide and prostaglandins","volume":"607","author":"Heeba","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nut.2016.01.010_bib37","doi-asserted-by":"crossref","first-page":"623","DOI":"10.9734\/EJMP\/2014\/8213","article-title":"Effects of l-arginine and l-citrulline on indomethacin-induced gastric ulceration and gastric pH in male albino rats","volume":"4","author":"Usman","year":"2014","journal-title":"Europ J Med Plants"},{"key":"10.1016\/j.nut.2016.01.010_bib38","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1472-6882-14-378","article-title":"Evaluation of acute toxicity and gastroprotective activity of Curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats","volume":"14","author":"Rouhollahi","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.nut.2016.01.010_bib39","first-page":"179","article-title":"Up-regulation of endothelin-1 in gastric mucosal inflammatory response to Helicobacter pylori lipopolysaccharide: Effect of omeprazole and sucralfate","volume":"51","author":"Slomiany","year":"2000","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.nut.2016.01.010_bib40","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3923\/ijp.2011.682.689","article-title":"The role of alpha-2 adrenergic receptors in the anti-ulcerative activity of famotidine and omeprazole in rats and its relationship with oxidant-antioxidant parameters","volume":"7","author":"Kisaoglu","year":"2011","journal-title":"Int J Pharmacol"},{"key":"10.1016\/j.nut.2016.01.010_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5152\/eajm.2012.09","article-title":"The role of alpha-2 adrenergic receptors in anti-ulcer activity","volume":"44","author":"Suleyman","year":"2012","journal-title":"Eurasian J Med"},{"key":"10.1016\/j.nut.2016.01.010_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejphar.2005.06.055","article-title":"Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing","volume":"519","author":"Poonam","year":"2005","journal-title":"Eur J Pharmacol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089990071600040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089990071600040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T22:20:30Z","timestamp":1567549230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089990071600040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":42,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S089990071600040X"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2016.01.010","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2016.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}