{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:19:32Z","timestamp":1789978772452,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","nutritionjrnl.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.nut.2017.02.010","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T06:45:45Z","timestamp":1488437145000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Stereology shows that damaged liver recovers after protein refeeding"],"prefix":"10.1016","volume":"38","author":[{"given":"Silvio Pires","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Almeida Pinto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Rabello","family":"Crisma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primavera","family":"Borelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Hernandez-Blazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana P.","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Loesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Augusto","family":"Coppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2017.02.010_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10753-009-9163-x","article-title":"Effects of protein\u2013energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages","volume":"33","author":"Fock","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.nut.2017.02.010_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/nu7010265","article-title":"Nutritional interventions in head and neck cancer patients\u00a0undergoing chemoradiotherapy: a narrative review","volume":"7","author":"Bossola","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2017.02.010_bib3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3945\/ajcn.116.131797","article-title":"Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype","volume":"104","author":"Mayneris-Perxachs","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2017.02.010_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000401762","article-title":"Biology of protein-calorie malnutrition","volume":"32","author":"Deo","year":"1978","journal-title":"World Rev Nutr Diet"},{"key":"10.1016\/j.nut.2017.02.010_bib5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.acthis.2014.11.012","article-title":"Liver damage and caspase-dependent apoptosis is related to protein\u00a0malnutrition in mice: effect of methionine","volume":"117","author":"Caballero","year":"2015","journal-title":"Acta Histochem"},{"key":"10.1016\/j.nut.2017.02.010_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.nut.2009.06.016","article-title":"Soybean diet\u00a0alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition","volume":"26","author":"Feres","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2017.02.010_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1010853719232","article-title":"Two dimensional non equilibrium pH gel electrophoresis mapping of cytosolic protein changes caused by dietary protein depletion in mouse liver","volume":"220","author":"Sanllorenti","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nut.2017.02.010_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s13105-010-0014-x","article-title":"Oxidative stress in mouse liver caused by dietary amino acid deprivation: Protective effect of methionine","volume":"66","author":"Ronchi","year":"2010","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.nut.2017.02.010_bib9","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/jn\/133.10.3085","article-title":"Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria","volume":"133","author":"Park","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2017.02.010_bib10","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2017.02.010_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0007114507172731","article-title":"Reduction of erythroid progenitors in protein-energy malnutrition","volume":"97","author":"Borelli","year":"2007","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2017.02.010_bib12","first-page":"531","article-title":"Radioimmunoassay for the determination of serum cortiscoterone in ducks (Anas platyrhynchos)","volume":"40","author":"Kratzsch","year":"1986","journal-title":"Arch Exp Veterin\u00e3rmed"},{"key":"10.1016\/j.nut.2017.02.010_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2006.03.038","article-title":"Expression of purinergic receptors in the hypothalamus of the rat is modified by reduced food availability","volume":"1089","author":"Seidel","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.nut.2017.02.010_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2818.1986.tb04282.x","article-title":"Estimation of surface area from vertical sections","volume":"142","author":"Baddeley","year":"1986","journal-title":"J Microsc"},{"key":"10.1016\/j.nut.2017.02.010_bib15","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gut.35.9.1275","article-title":"Diverting colostomy induces mucosal and muscular atrophy in rat distal colon","volume":"35","author":"Kissmeyer-Nielsen","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.nut.2017.02.010_bib16","first-page":"858","article-title":"The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"10.1016\/j.nut.2017.02.010_bib17","first-page":"57","article-title":"A simple method for volumetry of organs in quantitative stereology","volume":"26","author":"Scherle","year":"1970","journal-title":"Mikroskopie"},{"key":"10.1016\/j.nut.2017.02.010_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2818.2002.01054.x","article-title":"The smooth fractionator","volume":"207","author":"Gundersen","year":"2002","journal-title":"J Microsc"},{"key":"10.1016\/j.nut.2017.02.010_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2818.1977.tb00062.x","article-title":"Notes of the estimation of the numerical density of arbitrary profiles: the edge effect","volume":"111","author":"Gundersen","year":"1977","journal-title":"J Microsc"},{"key":"10.1016\/j.nut.2017.02.010_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2818.1993.tb03321.x","article-title":"The rotator","volume":"170","author":"Vedel-Jensen","year":"1993","journal-title":"J Microsc"},{"key":"10.1016\/j.nut.2017.02.010_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology \u2013 reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J Microsc"},{"key":"10.1016\/j.nut.2017.02.010_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.nut.2017.02.010_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0095-4543(05)70347-X","article-title":"Evaluation of tests used to screen patients with liver disorders","volume":"23","author":"Scheig","year":"1996","journal-title":"Prim Care"},{"key":"10.1016\/j.nut.2017.02.010_bib24","doi-asserted-by":"crossref","first-page":"E0157053","DOI":"10.1371\/journal.pone.0157053","article-title":"Malnutrition in Alzheimer's disease, dementia with Lewy Bodies, and frontotemporal lobar degeneration: comparison using serum albumin, total protein, and hemoglobin level","volume":"11","author":"Koyama","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2017.02.010_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3889\/oamjms.2016.094","article-title":"The association between malnutrition and pressure ulcers in elderly in long-term care facility","volume":"4","author":"Neloska","year":"2016","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.nut.2017.02.010_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000459078","article-title":"Studies on the mechanism of the increase in serum alkaline phosphatase activity in cholestasis: significance of the hepatic bile acid concentration for the leakage of alkaline phosphatase from rat liver","volume":"28","author":"Schlaeger","year":"1982","journal-title":"Enzyme"},{"key":"10.1016\/j.nut.2017.02.010_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00004836-200210000-00012","article-title":"Connective tissue diseases and the liver","volume":"35","author":"Youssef","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.nut.2017.02.010_bib28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.micron.2008.12.006","article-title":"Stereological study of the effects of nandrolone decanoate on the mouse liver","volume":"40","author":"Karbalay-Doust","year":"2009","journal-title":"Micron"},{"key":"10.1016\/j.nut.2017.02.010_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/S0074-02762006000900039","article-title":"Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet","volume":"101","author":"Neves","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.nut.2017.02.010_bib30","first-page":"93","article-title":"Overweight and structural alterations of the liver in female rats fed a high-fat diet: a stereological and histological study","volume":"20","author":"Altunkaynak","year":"2009","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.nut.2017.02.010_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1478-3231.2005.01201.x","article-title":"Design-based stereological estimation of hepatocyte number, by combining the smooth optical fractionator and immunocytochemistry with anti-carcinoembryonic antigen polyclonal antibodies","volume":"26","author":"Marcos","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.nut.2017.02.010_bib32","first-page":"934","article-title":"Immunohistochemical evaluation of hepatoblastomas\u00a0with use of the hepatocyte-specific marker, hepatocyte paraffin 1, and the polyclonal anti-carcinoembryonic antigen","volume":"11","author":"Fasano","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1016\/j.nut.2017.02.010_bib33","series-title":"Manual of histologic staining methods of the Armed Forces\u00a0Institute of Pathology","author":"Luna","year":"1968"},{"key":"10.1016\/j.nut.2017.02.010_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0378-4274(98)00246-X","article-title":"New approaches to the quantitation of hypertrophy and hyperplasia in hepatomegaly","volume":"102\u2013103","author":"Carthew","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.nut.2017.02.010_bib35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/0192623313486316","article-title":"Parenteral solution of nutritional hepatotrophic factors improves regeneration in thioacetamide-induced cirrhotic livers after partial hepatectomy","volume":"42","author":"Trotta","year":"2014","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.nut.2017.02.010_bib36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1095-6433(02)00374-4","article-title":"Hepatocyte ploidy in the normal rat","volume":"134","author":"Gandillet","year":"2003","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.nut.2017.02.010_bib37","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/carcin\/11.7.1149","article-title":"Studies on the hyperplastic responsiveness of binucleated hepatocytes","volume":"11","author":"Styles","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.nut.2017.02.010_bib38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/carcin\/8.3.391","article-title":"A cytological comparison between regeneration, hyperplasia and early neoplasia in the rat liver","volume":"8","author":"Styles","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.nut.2017.02.010_bib39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/hep.1840110220","article-title":"Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereolocal study using the nucleator method","volume":"11","author":"Jack","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2017.02.010_bib40","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.28573","article-title":"MicroRNA-122 regulates polyploidization in the murine liver","volume":"64","author":"Hsu","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2017.02.010_bib41","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1590\/S1516-31801995000300004","article-title":"Reduction of liver mass due to malnutrition in rats. Correlation with emaciation of animals and size of organs not inserted in the portal system","volume":"113","author":"Parra","year":"1995","journal-title":"Sao Paulo Med J"},{"key":"10.1016\/j.nut.2017.02.010_bib42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0140-6736(75)92076-0","article-title":"Intraportal insulin protects from the liver injury of portacaval shunt in dogs","volume":"2","author":"Starzl","year":"1975","journal-title":"Lancet"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900717300424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900717300424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T03:14:47Z","timestamp":1568862887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900717300424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":42,"alternative-id":["S0899900717300424"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2017.02.010","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stereology shows that damaged liver recovers after protein refeeding","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2017.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}