{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T20:49:53Z","timestamp":1774298993518,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","nutritionjrnl.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.nut.2017.08.007","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T04:30:33Z","timestamp":1502339433000},"page":"153-158.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying"],"prefix":"10.1016","volume":"46","author":[{"given":"Fumika","family":"Mano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erina","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2017.08.007_bib1","unstructured":"US Department of Agriculture. Dietary guidelines for Americans 2010. Available at: http:\/\/www.dietaryguidelines.gov. Accessed March 5, 2017."},{"key":"10.1016\/j.nut.2017.08.007_bib2","series-title":"Flavor and seasonings: dashi, umami, and fermented foods","first-page":"9","article-title":"Japanese cuisine and the culture of umami","author":"Kumakura","year":"2017"},{"key":"10.1016\/j.nut.2017.08.007_bib3","series-title":"Flavor and seasonings: dashi, umami, and fermented foods","first-page":"59","article-title":"Dashi making techniques","author":"Kumakura","year":"2017"},{"key":"10.1016\/j.nut.2017.08.007_bib4","series-title":"Flavor and seasonings: dashi, umami, and fermented foods","first-page":"6","article-title":"Preface","author":"Murata","year":"2017"},{"key":"10.1016\/j.nut.2017.08.007_bib5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.physbeh.2007.07.002","article-title":"Effect of dried-bonito broth on mental fatigue and mental task performance in subjects with a high fatigue score","volume":"92","author":"Kuroda","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.nut.2017.08.007_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.physbeh.2007.08.021","article-title":"Effect of dried-bonito broth intake on peripheral blood flow, mood, and oxidative stress marker in humans","volume":"93","author":"Nozawa","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1016\/j.nut.2017.08.007_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3164\/jcbn.2008061","article-title":"The effect of the dried-bonito broth on blood pressure, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, and emotional states in elderly subjects","volume":"43","author":"Umeki","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.nut.2017.08.007_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1749-6632.2009.03900.x","article-title":"Effect of free dietary\u00a0glutamate on gastric secretion in dogs","volume":"1170","author":"Zolotarev","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"suppl","key":"10.1016\/j.nut.2017.08.007_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2152\/jmi.56.218","article-title":"Dietary monosodium glutamate enhances gastric secretion","volume":"56","author":"Khropycheva","year":"2009","journal-title":"J Med Invest"},{"issue":"suppl 1","key":"10.1016\/j.nut.2017.08.007_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000323398","article-title":"Dietary glutamate signal evokes gastric juice excretion in dogs","volume":"83","author":"Khropycheva","year":"2011","journal-title":"Digestion"},{"issue":"suppl","key":"10.1016\/j.nut.2017.08.007_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2152\/jmi.56.197","article-title":"Contribution of umami taste substances in human salivation during meal","volume":"56","author":"Uneyama","year":"2009","journal-title":"J Med Invest"},{"issue":"suppl 1","key":"10.1016\/j.nut.2017.08.007_bib12","doi-asserted-by":"crossref","first-page":"i11","DOI":"10.1136\/gut.51.suppl_1.i11","article-title":"Visceral perception: sensory transduction in visceral afferents and nutrients","volume":"51","author":"Raybould","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.nut.2017.08.007_bib13","doi-asserted-by":"crossref","first-page":"E83","DOI":"10.1152\/ajpendo.2000.278.1.E83","article-title":"Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans","volume":"278","author":"Graham","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2017.08.007_bib14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/apt.12050","article-title":"Monosodium glutamate stimulates secretion of glucagon-like peptide-1 and reduces postprandial glucose after a lipid-containing meal","volume":"36","author":"Hosaka","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nut.2017.08.007_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-2125.2002.01596.x","article-title":"Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteers","volume":"53","author":"Chevassus","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.nut.2017.08.007_bib16","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1017\/S0007114513001633","article-title":"Glutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males","volume":"110","author":"Di Sebastiano","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2017.08.007_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3945\/ajcn.2008.26180","article-title":"Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying","volume":"89","author":"Zai","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2017.08.007_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00125-015-3841-z","article-title":"Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial","volume":"59","author":"Kuwata","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.nut.2017.08.007_bib19","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/0016-5085(93)90640-X","article-title":"Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test","volume":"104","author":"Ghoos","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nut.2017.08.007_bib20","first-page":"824","article-title":"Combined carbon-13-glycine\/carbon-14-octanoic acid breath test to monitor gastric emptying rates of liquids and solids","volume":"35","author":"Maes","year":"1994","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nut.2017.08.007_bib21","doi-asserted-by":"crossref","first-page":"176.e87","DOI":"10.1111\/nmo.12025","article-title":"Gastric secretion does not affect the reliability of the 13 C-acetate breath test: a validation of the 13 C-acetate breath test by magnetic resonance imaging","volume":"25","author":"Kuyumcu","year":"2013","journal-title":"Neurogastroenterol Motil"},{"issue":"suppl","key":"10.1016\/j.nut.2017.08.007_bib22","doi-asserted-by":"crossref","first-page":"971.s","DOI":"10.1093\/jn\/130.4.971S","article-title":"Reflex effects of oral, gastrointestinal and hepatoportal glutamate sensors on vagal nerve activity","volume":"130","author":"Niijima","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2017.08.007_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.physbeh.2006.08.011","article-title":"The effect of monosodium glutamate on parotid salivary flow in comparison to the response to representatives of the other four basic tastes","volume":"89","author":"Hodson","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1016\/j.nut.2017.08.007_bib24","doi-asserted-by":"crossref","first-page":"G1163","DOI":"10.1152\/ajpgi.00587.2005","article-title":"Luminal amino acid sensing in the rat gastric mucosa","volume":"291","author":"Uneyama","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.nut.2017.08.007_bib25","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.febslet.2007.02.016","article-title":"mGluR1 in the fundic glands of rat stomach","volume":"581","author":"San Gabriel","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.nut.2017.08.007_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/chemse\/bjl034","article-title":"Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells","volume":"32","author":"Bezencon","year":"2007","journal-title":"Chem Senses"},{"key":"10.1016\/j.nut.2017.08.007_bib27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0031-9384(91)90192-Q","article-title":"Basic properties of umami and effects on humans","volume":"49","author":"Yamaguchi","year":"1991","journal-title":"Physiol Behav"},{"key":"10.1016\/j.nut.2017.08.007_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0031-9384(94)90194-5","article-title":"Taste perception of monosodium glutamate (MSG) in foods in young and elderly subjects","volume":"56","author":"Schiffman","year":"1994","journal-title":"Physiol Behav"},{"key":"10.1016\/j.nut.2017.08.007_bib29","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.2337\/diacare.24.9.1640","article-title":"Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men","volume":"24","author":"Rask","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2017.08.007_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.2040-1124.2010.00078.x","article-title":"Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects","volume":"2","author":"Harada","year":"2011","journal-title":"J\u00a0Diabetes Investig"},{"key":"10.1016\/j.nut.2017.08.007_bib31","first-page":"E981","article-title":"Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans","volume":"273","author":"Nauck","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nut.2017.08.007_bib32","first-page":"G920","article-title":"Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms","volume":"273","author":"Imeryuz","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nut.2017.08.007_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.2040-1124.2011.00143.x","article-title":"Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance","volume":"3","author":"Yamane","year":"2012","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.nut.2017.08.007_bib34","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nut.2017.08.007_bib35","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1053\/gast.1996.v110.pm8612991","article-title":"Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia","volume":"110","author":"Stanghellini","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nut.2017.08.007_bib36","first-page":"932082","article-title":"Patterns of symptoms in functional dyspepsia: role of Helicobacter pylori infection and delayed gastric emptying","author":"Perri","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.nut.2017.08.007_bib37","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/gut.2005.078634","article-title":"Functional dyspepsia, delayed gastric emptying, and impaired quality of life","volume":"55","author":"Talley","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.nut.2017.08.007_bib38","first-page":"Cd001960","article-title":"Pharmacological interventions for non-ulcer dyspepsia","author":"Moayyedi","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.nut.2017.08.007_bib39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1440-1746.2006.04493.x","article-title":"Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia","volume":"22","author":"Hiyama","year":"2007","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900717301740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900717301740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T06:40:08Z","timestamp":1569998408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900717301740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":39,"alternative-id":["S0899900717301740"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2017.08.007","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2017.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}