{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:09:21Z","timestamp":1791590961484,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"UGC-FRPS","award":["30-12\/2014"],"award-info":[{"award-number":["30-12\/2014"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.nut.2018.02.013","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T14:51:42Z","timestamp":1521557502000},"page":"118-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Bacillus clausii inhibits bone loss by skewing Treg-Th17 cell equilibrium in postmenopausal osteoporotic mice model"],"prefix":"10.1016","volume":"54","author":[{"given":"Hamid Y.","family":"Dar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashis","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradyumna K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetanjali B.","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupesh K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2018.02.013_bib0010","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1007\/s00198-017-4049-5","article-title":"Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults","volume":"28","author":"Laird","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.nut.2018.02.013_bib0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jama.285.3.320","article-title":"Risk of new vertebral fracture in the year following a fracture","volume":"285","author":"Lindsay","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.nut.2018.02.013_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis","volume":"31","author":"Manolagas","year":"2010","journal-title":"Endocr Rev"},{"key":"10.1016\/j.nut.2018.02.013_bib0025","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1182\/blood-2009-11-255026","article-title":"Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells","volume":"116","author":"Li","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.nut.2018.02.013_bib0030","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.4049\/jimmunol.0903841","article-title":"Regulatory T cells protect from local and systemic bone destruction in arthritis","volume":"184","author":"Zaiss","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000443531","article-title":"Upregulated cellular expression of IL-17 by CD4+ T-cells in osteoporotic postmenopausal women","volume":"68","author":"Zhao","year":"2016","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nut.2018.02.013_bib0040","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1172\/JCI30074","article-title":"IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation","volume":"117","author":"Gao","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2018.02.013_bib0045","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/rheumatology\/kep028","article-title":"Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis","volume":"48","author":"Nistala","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.nut.2018.02.013_bib0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-12-394299-9.00002-3","article-title":"Autoimmune arthritis: the interface between the immune system and joints","volume":"15","author":"Komatsu","year":"2012","journal-title":"Adv Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0055","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/eji.201141938","article-title":"T helper cell populations: as flexible as the skin?","volume":"41","author":"Waisman","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0060","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","article-title":"IL-17 stimulates the production and expression of proinflammatory cytokines, IL-\u03b2 and TNF-\u03b1, by human macrophages","volume":"160","author":"Jovanovic","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0065","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"Kotake","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2018.02.013_bib0070","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar2936","article-title":"Interleukin-17 A upregulates receptor activator of NF-\u03baB on osteoclast precursors","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.nut.2018.02.013_bib0075","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1002\/art.34565","article-title":"Th17 cells are restrained by treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy","volume":"64","author":"McGovern","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.nut.2018.02.013_bib0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","article-title":"The Treg\/Th17 axis: a dynamic balance regulated by the gut microbiome","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0085","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.20070602","article-title":"Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid","volume":"204","author":"Sun","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.nut.2018.02.013_bib0090","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut immune maturation depends on colonization with a host-specific microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nut.2018.02.013_bib0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ibd.21709","article-title":"Consumption of probiotics increases the effect of regulatory T cells in transfer colitis","volume":"18","author":"Petersen","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.nut.2018.02.013_bib0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000080455","article-title":"Effects of long-term intervention with lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats","volume":"48","author":"Narva","year":"2004","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nut.2018.02.013_bib0105","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1021\/jf2013716","article-title":"Anti-osteoporotic effects of Lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice","volume":"59","author":"Chiang","year":"2011","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nut.2018.02.013_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092368","article-title":"Probiotics protect mice from ovariectomy-induced cortical bone loss","volume":"9","author":"Ohlsson","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nut.2018.02.013_bib0115","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","article-title":"Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model","volume":"229","author":"Britton","year":"2014","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nut.2018.02.013_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI86062","article-title":"Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics","volume":"126","author":"Li","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2018.02.013_bib0125","first-page":"18","article-title":"Probiotics and bone health: it takes GUTS to improve bone density","volume":"1","author":"Yousf","year":"2015","journal-title":"Int J Immunother Cancer Res"},{"key":"10.1016\/j.nut.2018.02.013_bib0130","first-page":"2239","article-title":"Osteoimmunology: the nexus between bone and immune system","volume":"22","author":"Dar","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.nut.2018.02.013_bib0135","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.nut.2018.02.013_bib0140","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1038\/s41598-018-20896-y","article-title":"High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone microarchitecture in male mice","volume":"8","author":"Dar","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.nut.2018.02.013_bib0145","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.4049\/jimmunol.1002691","article-title":"IL-3 attenuates collagen-induced arthritis by modulating the development of Foxp3+ regulatory T cells","volume":"186","author":"Srivastava","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0150","series-title":"Modern research and educational topics in microscopy","first-page":"37","article-title":"Imaging of bone ultrastructure using atomic force microscopy","author":"Thurner","year":"2007"},{"key":"10.1016\/j.nut.2018.02.013_bib0155","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1158\/0008-5472.CAN-10-3922","article-title":"CD8+ T cells regulate bone tumor burden independent of osteoclast resorption","volume":"71","author":"Zhang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.nut.2018.02.013_bib0160","first-page":"1","article-title":"Bone composition: relationship to bone fragility and anti-osteoporotic drug effects","volume":"4","author":"Boskey","year":"2013","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.nut.2018.02.013_bib0165","doi-asserted-by":"crossref","first-page":"838 S","DOI":"10.1093\/jn\/137.3.838S","article-title":"Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure","volume":"137","author":"Scholz-Ahrens","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2018.02.013_bib0170","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"Bone Rep"},{"key":"10.1016\/j.nut.2018.02.013_bib0175","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1128\/AEM.71.2.968-978.2005","article-title":"Screening for bacillus isolates in the broiler gastrointestinal tract","volume":"71","author":"Barbosa","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.nut.2018.02.013_bib0180","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0923-2508(00)00159-5","article-title":"On the fate of ingested Bacillus spores","volume":"151","author":"Spinosa","year":"2000","journal-title":"Res Microbiol"},{"key":"10.1016\/j.nut.2018.02.013_bib0185","first-page":"197","article-title":"The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000","volume":"81","author":"Kosek","year":"2003","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.nut.2018.02.013_bib0190","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-1135(97)00102-8","article-title":"Effect of Bacillus subtilis spore administration on activation of macrophages and natural killer cells in mice","volume":"60","author":"Kosak","year":"1998","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.nut.2018.02.013_bib0195","first-page":"152","article-title":"Bacillus subtilis spores as a natural pro-host oral agent. Preliminary data in children","volume":"3","author":"Novelli","year":"1984","journal-title":"Chemioterapia"},{"key":"10.1016\/j.nut.2018.02.013_bib0200","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1399-3038.2003.00102.x","article-title":"Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: a pilot study","volume":"15","author":"Ciprandi","year":"2004","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0205","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/1521-4141(200107)31:7<2179::AID-IMMU2179>3.0.CO;2-X","article-title":"Osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8+ T cells","volume":"31","author":"Choi","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0210","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/cmi.2010.54","article-title":"Estrogen enhances the functions of CD4+CD25+Foxp3+ regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro","volume":"8","author":"Luo","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.nut.2018.02.013_bib0215","first-page":"943","article-title":"Bacillus clausii and gut homeostasis: state of the art and future perspectives","volume":"10","author":"Lopetuso","year":"2016","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.nut.2018.02.013_bib0220","first-page":"1113","article-title":"Estrogen deficiency, postmenopausal osteoporosis, and age-related bone loss","volume":"vol. 1","author":"Khosla","year":"2013"},{"key":"10.1016\/j.nut.2018.02.013_bib0225","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/imr.12035","article-title":"The Th17 family: flexibility follows function","volume":"252","author":"Basu","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.nut.2018.02.013_bib0230","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrendo.2016.91","article-title":"Physiological and pathophysiological bone turnover-role of the immune system","volume":"12","author":"Weitzmann","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.nut.2018.02.013_bib0235","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"111","author":"Eghbali-fatourechi","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2018.02.013_bib0240","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signaling crosstalk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900718300923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900718300923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T04:45:24Z","timestamp":1719895524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900718300923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":47,"alternative-id":["S0899900718300923"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2018.02.013","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacillus clausii inhibits bone loss by skewing Treg-Th17 cell equilibrium in postmenopausal osteoporotic mice model","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2018.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}