{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:32:55Z","timestamp":1789263175336,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Serbian Ministry of Education, Science and Technological Development","award":["175037"],"award-info":[{"award-number":["175037"]}]},{"name":"Provincial Secretariat for Higher Education and Scientific Research","award":["114-451-710"],"award-info":[{"award-number":["114-451-710"]}]},{"name":"Faculty of Sport and Physical Education"},{"name":"Center for Health, Exercise and Sport Sciences"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.nut.2018.04.009","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T02:36:45Z","timestamp":1526524605000},"page":"162-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial"],"prefix":"10.1016","volume":"57","author":[{"given":"Sasa","family":"Semeredi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdemar","family":"Stajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Vranes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej M.","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2018.04.009_bib0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fphys.2015.00109","article-title":"Diet impact on mitochondrial bioenergetics and dynamics","volume":"6","author":"Putti","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.nut.2018.04.009_bib0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-319-55330-6_4","article-title":"Mitochondrial bioenergetics and dysfunction in failing heart","volume":"982","author":"Sheeran","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.nut.2018.04.009_bib0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12970-017-0173-z","article-title":"International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine","volume":"14","author":"Kreider","year":"2017","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.nut.2018.04.009_bib0025","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00726-015-2165-0","article-title":"Creatine for neuroprotection in neurodegenerative disease: end of story?","volume":"48","author":"Bender","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.nut.2018.04.009_bib0030","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1139\/apnm-2016-0178","article-title":"Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men","volume":"41","author":"Ostojic","year":"2016","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.nut.2018.04.009_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.nut.2016.09.010","article-title":"Tackling guanidinoacetic acid for advanced cellular bioenergetics","volume":"34","author":"Ostojic","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2018.04.009_bib0040","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1271\/bbb.70791","article-title":"Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats","volume":"72","author":"Setoue","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.nut.2018.04.009_bib0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1055\/s-0034-1386772","article-title":"Cerebral creatine deficiencies: a group of treatable intellectual developmental disorders","volume":"34","author":"Stockler-Ipsiroglu","year":"2014","journal-title":"Semin Neurol"},{"key":"10.1016\/j.nut.2018.04.009_bib0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biopha.2017.04.075","article-title":"Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: a novel approach?","volume":"91","author":"Ostojic","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nut.2018.04.009_bib0055","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1550-2783-9-33","article-title":"Creatine supplementation with specific view to exercise\/sports performance: an update","volume":"9","author":"Cooper","year":"2012","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.nut.2018.04.009_bib0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.7150\/ijms.5125","article-title":"Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans","volume":"10","author":"Ostojic","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.nut.2018.04.009_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032557","article-title":"\u03b3-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats","volume":"7","author":"Tachikawa","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nut.2018.04.009_bib0070","doi-asserted-by":"crossref","first-page":"E1095","DOI":"10.1152\/ajpendo.2001.281.5.E1095","article-title":"Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate","volume":"281","author":"Stead","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nut.2018.04.009_bib0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1152\/jappl.1996.81.1.232","article-title":"Muscle creatine loading in men","volume":"81","author":"Hultman","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nut.2018.04.009_bib0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1123\/ijsnem.13.1.97","article-title":"Creatine supplementation: a comparison of loading and maintenance protocols on creatine uptake by human skeletal muscle","volume":"13","author":"Preen","year":"2003","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.nut.2018.04.009_bib0085","first-page":"610","article-title":"Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders","volume":"18","author":"Syrotuik","year":"2004","journal-title":"J Strength Cond Res"},{"key":"10.1016\/j.nut.2018.04.009_bib0090","first-page":"102","article-title":"Oral creatine supplements lower plasma homocysteine concentrations in humans","volume":"17","author":"Korzun","year":"2004","journal-title":"Clin Lab Sci"},{"key":"10.1016\/j.nut.2018.04.009_bib0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jmr.618","article-title":"Long-range and short-range mechanisms of hydrophobic attraction and hydrophilic repulsion in specific and aspecific interactions","volume":"16","author":"van Oss","year":"2003","journal-title":"J Mol Recognit"},{"key":"10.1016\/j.nut.2018.04.009_bib0100","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/JIM.0000000000000212","article-title":"Six-week oral guanidinoacetic acid administration improves muscular performance in healthy volunteers","volume":"63","author":"Ostojic","year":"2015","journal-title":"J Investig Med"},{"key":"10.1016\/j.nut.2018.04.009_bib0105","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1111\/j.1742-4658.2008.06718.x","article-title":"Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells","volume":"275","author":"Bera","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.nut.2018.04.009_bib0110","first-page":"1","article-title":"Safety and efficacy of guanidinoacetic acid as feed additive for chickens for fattening","volume":"988","author":"European Food Safety Authority","year":"2009","journal-title":"EFSA J"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900718303617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900718303617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:08:10Z","timestamp":1760270890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900718303617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":21,"alternative-id":["S0899900718303617"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2018.04.009","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2018.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}