{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:12:53Z","timestamp":1791817973807,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Fo 695\/2\\u20132"],"award-info":[{"award-number":["Fo 695\/2\\u20132"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Fo 695\/6\\u20131"],"award-info":[{"award-number":["Fo 695\/6\\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.nut.2020.110988","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T21:56:51Z","timestamp":1598565411000},"page":"110988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Vitamin A regulates fibroblast growth factor 23 (FGF23)"],"prefix":"10.1016","volume":"79-80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-5807","authenticated-orcid":false,"given":"Steffen","family":"Rausch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Barholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"F\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Feger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2020.110988_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","article-title":"FGF23 at the crossroads of phosphate, iron economy and erythropoiesis","volume":"16","author":"Edmonston","year":"2020","journal-title":"Nature reviews. Nephrology"},{"key":"10.1016\/j.nut.2020.110988_bib0002","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2016.10.001","article-title":"Cardiac actions of fibroblast growth factor 23","volume":"100","author":"Faul","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.nut.2020.110988_bib0003","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2020.110988_bib0004","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1172\/JCI83470","article-title":"FGF23 signaling impairs neutrophil recruitment and host defense during CKD","volume":"126","author":"Rossaint","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2020.110988_bib0005","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2020.110988_bib0006","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nut.2018.09.001","article-title":"Influence of dietary vitamin D deficiency on bone strength, body composition, and muscle in ovariectomized rats fed a high-fat diet","volume":"60","author":"Nakaoka","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2020.110988_bib0007","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nut.2020.110988_bib0008","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrneph.2013.111","article-title":"Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism","volume":"9","author":"Kuro-o","year":"2013","journal-title":"Nature reviews. Nephrology"},{"key":"10.1016\/j.nut.2020.110988_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/358086","article-title":"FGF23 in acute and chronic illness","volume":"2015","author":"Schnedl","year":"2015","journal-title":"Dis Markers"},{"key":"10.1016\/j.nut.2020.110988_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184634","article-title":"FGF23-mediated activation of local RAAS promotes cardiac hypertrophy and fibrosis","volume":"20","author":"B\u00f6ckmann","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nut.2020.110988_bib0011","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/ki.2014.215","article-title":"Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription","volume":"86","author":"Meir","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2020.110988_bib0012","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2020.110988_bib0013","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2215\/CJN.04730510","article-title":"Effects of dietary phosphate and calcium intake on fibroblast growth factor-23","volume":"6","author":"Vervloet","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nut.2020.110988_bib0014","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MNH.0000000000000232","article-title":"Inflammation regulates fibroblast growth factor 23 production","volume":"25","author":"Francis","year":"2016","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.nut.2020.110988_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174195","article-title":"The role of fibroblast growth factor 23 in inflammation and anemia","volume":"20","author":"Czaya","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nut.2020.110988_bib0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2020.110988_bib0017","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1073\/pnas.1800160115","article-title":"Insulin suppresses the production of fibroblast growth factor 23 (FGF23)","volume":"115","author":"B\u00e4r","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nut.2020.110988_bib0018","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.kint.2018.03.006","article-title":"AMP-activated kinase is a regulator of fibroblast growth factor 23 production","volume":"94","author":"Glosse","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2020.110988_bib0019","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nut.2018.09.031","article-title":"Vitamin D, muscle recovery, sarcopenia, cachexia, and muscle atrophy","volume":"60","author":"Garcia","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2020.110988_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153610","article-title":"All-trans retinoic acid as a versatile cytosolic signal modulator mediated by CRABP1","volume":"20","author":"Nagpal","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nut.2020.110988_bib0021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nut.2018.06.007","article-title":"Vitamin A supplementation improves the intestinal mucosal barrier and facilitates the expression of tight junction proteins in rats with diarrhea","volume":"57","author":"Xiao","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2020.110988_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801045","article-title":"An overview of carotenoids, apocarotenoids, and vitamin A in agro-food, nutrition, health, and disease","volume":"63","author":"Mel\u00e9ndez-Mart\u00ednez","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.nut.2020.110988_bib0023","doi-asserted-by":"crossref","first-page":"e82388","DOI":"10.1371\/journal.pone.0082388","article-title":"Vitamin a is a negative regulator of osteoblast mineralization","volume":"8","author":"Lind","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2020.110988_bib0024","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fendo.2015.00031","article-title":"Retinoid receptors in bone and their role in bone remodeling","volume":"6","author":"Henning","year":"2015","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.nut.2020.110988_bib0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/BCJ20190716","article-title":"All-trans retinoic acid reduces the transcriptional regulation of intestinal sodium-dependent phosphate co-transporter gene (Npt2b)","volume":"477","author":"Masuda","year":"2020","journal-title":"Biochem J"},{"key":"10.1016\/j.nut.2020.110988_bib0026","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00223-012-9683-5","article-title":"1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6","volume":"92","author":"Saini","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.nut.2020.110988_bib0027","doi-asserted-by":"crossref","first-page":"D51","DOI":"10.1093\/nar\/gkw1069","article-title":"The eukaryotic promoter database in its 30th year: focus on non-vertebrate organisms","volume":"45","author":"Dreos","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.nut.2020.110988_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215495","article-title":"CiiiDER: a tool for predicting and analysing transcription factor binding sites","volume":"14","author":"Gearing","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2020.110988_bib0029","doi-asserted-by":"crossref","first-page":"e13104","DOI":"10.1111\/dth.13104","article-title":"Depression, isotretinoin, and folic acid: a practical review","volume":"32","author":"Abdelmaksoud","year":"2019","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.nut.2020.110988_bib0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jnutbio.2017.05.007","article-title":"The change in retinoic acid receptor signaling induced by prenatal marginal vitamin A deficiency and its effects on learning and memory","volume":"47","author":"Zhang","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2020.110988_bib0031","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/nu8110746","article-title":"Retinol dehydrogenases regulate vitamin A metabolism for visual function","volume":"8","author":"Sahu","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2020.110988_bib0032","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jocd.2013.08.016","article-title":"Vitamin A and bone health: the balancing act","volume":"16","author":"Tanumihardjo","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.nut.2020.110988_bib0033","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.nut.2020.110988_bib0034","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1093\/ndt\/gfr171","article-title":"Impact of vitamin A on clinical outcomes in haemodialysis patients","volume":"26","author":"Espe","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nut.2020.110988_bib0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.kint.2019.05.018","article-title":"FGF23 and inflammation-a vicious coalition in CKD","volume":"96","author":"Czaya","year":"2019","journal-title":"Kidney Int"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900720302719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900720302719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:46:51Z","timestamp":1778762811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900720302719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":35,"alternative-id":["S0899900720302719"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2020.110988","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A regulates fibroblast growth factor 23 (FGF23)","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2020.110988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110988"}}