{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:52:05Z","timestamp":1785585125538,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.nut.2020.111080","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:41:13Z","timestamp":1605822073000},"page":"111080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Development and course of diabetes according to genetic factors and diabetes treatment among patients with nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4324","authenticated-orcid":false,"given":"Tomomi","family":"Kogiso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Sagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Tokushige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2020.111080_bib0001","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nut.2020.111080_bib0002","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00535-012-0533-z","article-title":"Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: A multicenter large retrospective study","volume":"47","author":"Eguchi","year":"2012","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.nut.2020.111080_bib0003","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nut.2020.111080_bib0004","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2337\/dc06-2247","article-title":"Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients","volume":"30","author":"Targher","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0005","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2337\/dc10-2229","article-title":"Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study","volume":"34","author":"Williamson","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0006","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.2337\/dc07-0792","article-title":"Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men","volume":"30","author":"Shibata","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0007","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ajg.2009.67","article-title":"NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study","volume":"104","author":"Adams","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.nut.2020.111080_bib0008","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/hep.26183","article-title":"Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-year prospective cohort study","volume":"57","author":"Park","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2020.111080_bib0009","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/jgh.13264","article-title":"Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis","volume":"31","author":"Ballestri","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.nut.2020.111080_bib0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/1471-2350-11-172","article-title":"Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease","volume":"11","author":"Hotta","year":"2010","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.nut.2020.111080_bib0011","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhep.2014.02.030","article-title":"Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"61","author":"Liu","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.nut.2020.111080_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140427","article-title":"The impact of PNPLA3 rs738409 genetic polymorphism and weight gain \u226510 kg after age 20 on non-alcoholic fatty liver disease in non-obese Japanese individuals","volume":"10","author":"Nishioji","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2020.111080_bib0013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jgh3.12097","article-title":"Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease","volume":"3","author":"Yamamoto","year":"2019","journal-title":"JGH Open"},{"key":"10.1016\/j.nut.2020.111080_bib0014","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ng.208","article-title":"SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations","volume":"40","author":"Unoki","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.nut.2020.111080_bib0015","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ng.207","article-title":"Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus","volume":"40","author":"Yasuda","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.nut.2020.111080_bib0016","first-page":"408","article-title":"The KCNQ1 potassium channel: From gene to physiological function","volume":"20","author":"Jespersen","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.nut.2020.111080_bib0017","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s00125-012-2636-8","article-title":"Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes","volume":"55","author":"Yu","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.nut.2020.111080_bib0018","doi-asserted-by":"crossref","first-page":"e34229","DOI":"10.1371\/journal.pone.0034229","article-title":"Several polymorphisms of KCNQ1 gene are associated with plasma lipid levels in general Chinese populations","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2020.111080_bib0019","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1093\/hmg\/ddu248","article-title":"Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index","volume":"23","author":"Wen","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nut.2020.111080_bib0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1440-1681.2012.05701.x","article-title":"KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients","volume":"39","author":"Dai","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.nut.2020.111080_bib0021","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00535-015-1050-7","article-title":"Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"50","author":"Watanabe","year":"2015","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.nut.2020.111080_bib0022","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2020.111080_bib0023","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.nut.2020.111080_bib0024","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","article-title":"Current and future pharmacological therapies for NAFLD\/NASH","volume":"53","author":"Sumida","year":"2018","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.nut.2020.111080_bib0025","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa060326","article-title":"A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis","volume":"355","author":"Belfort","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nut.2020.111080_bib0026","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nut.2020.111080_bib0027","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.nut.2020.111080_bib0028","article-title":"Comment on: American Diabetes Association. Standards of medical care in diabetes\u20132011","volume":"34","author":"Basevi","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0029","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.2337\/dc14-S081","article-title":"Diagnosis and classification of diabetes mellitus","volume":"37","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecl.2013.09.009","article-title":"Metabolic syndrome","volume":"43","author":"Samson","year":"2014","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.nut.2020.111080_bib0031","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.nut.2020.111080_bib0032","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/jgh.14989","article-title":"Long-term outcomes of non-alcoholic fatty liver disease and the risk factors for mortality and hepatocellular carcinoma in a Japanese population","volume":"35","author":"Kogiso","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.nut.2020.111080_bib0033","doi-asserted-by":"crossref","first-page":"E146","DOI":"10.1111\/hepr.12552","article-title":"Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus","volume":"46","author":"Kan","year":"2016","journal-title":"Hepatol Res"},{"key":"10.1016\/j.nut.2020.111080_bib0034","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.2337\/db11-1516","article-title":"Reduced insulin exocytosis in human pancreatic \u03b2-cells with gene variants linked to type 2 diabetes","volume":"61","author":"Rosengren","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.nut.2020.111080_bib0035","doi-asserted-by":"crossref","first-page":"e5872","DOI":"10.1371\/journal.pone.0005872","article-title":"The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load","volume":"4","author":"Holmkvist","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2020.111080_bib0036","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.diabres.2017.05.018","article-title":"KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors","volume":"130","author":"Gotthardov\u00e1","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.nut.2020.111080_bib0037","doi-asserted-by":"crossref","first-page":"CR392","DOI":"10.12659\/MSM.881850","article-title":"Variation in KCNQ1 is associated with therapeutic response to sulphonylureas","volume":"17","author":"Schroner","year":"2011","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.nut.2020.111080_bib0038","doi-asserted-by":"crossref","first-page":"E42","DOI":"10.1111\/hepr.12925","article-title":"Insulin resistance increases the risk of incident type 2 diabetes mellitus in patients with non-alcoholic fatty liver disease","volume":"48","author":"Seko","year":"2018","journal-title":"Hepatol Res"},{"key":"10.1016\/j.nut.2020.111080_bib0039","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1464-5491.2008.02410.x","article-title":"Fatty liver is an independent risk factor for the development of type 2 diabetes in Korean adults","volume":"25","author":"Kim","year":"2008","journal-title":"Diabet Med"},{"key":"10.1016\/j.nut.2020.111080_bib0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/liv.12912","article-title":"The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals","volume":"36","author":"Fukuda","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.nut.2020.111080_bib0041","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s00125-018-4805-x","article-title":"The PNPLA3 rs738409 C>G variant interacts with changes in body weight over time to aggravate liver steatosis, but reduces the risk of incident type 2 diabetes","volume":"62","author":"Xia","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.nut.2020.111080_bib0042","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2337\/diacare.24.1.89","article-title":"Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development","volume":"24","author":"Weyer","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2020.111080_bib0043","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1210\/jc.2011-2272","article-title":"Insulin resistance and excess risk of diabetes in Mexican-Americans: The San Antonio Heart Study","volume":"97","author":"Lorenzo","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nut.2020.111080_bib0044","doi-asserted-by":"crossref","first-page":"E284","DOI":"10.1111\/j.1399-0012.2011.01417.x","article-title":"KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients","volume":"25","author":"Tavira","year":"2011","journal-title":"Clin Transplant"},{"key":"10.1016\/j.nut.2020.111080_bib0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.gendis.2015.02.009","article-title":"Correlation between","volume":"2","author":"Khan","year":"2015","journal-title":"Genes Dis"},{"key":"10.1016\/j.nut.2020.111080_bib0046","doi-asserted-by":"crossref","first-page":"115","DOI":"10.14712\/fb2017063030115","article-title":"KCNJ11 and KCNQ1 gene polymorphisms are not associated with post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus","volume":"63","author":"Dabrowska-Zamojcin","year":"2017","journal-title":"Folia Biol (Praha)"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900720303634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900720303634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:11:55Z","timestamp":1760271115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900720303634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":46,"alternative-id":["S0899900720303634"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2020.111080","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and course of diabetes according to genetic factors and diabetes treatment among patients with nonalcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2020.111080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111080"}}