{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:21:25Z","timestamp":1787851285126,"version":"build-2784847793"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701031"],"award-info":[{"award-number":["31701031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.nut.2021.111176","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T11:11:17Z","timestamp":1612005077000},"page":"111176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Dietary anthocyanin-rich extract of a\u00e7ai protects from diet-induced obesity, liver steatosis, and insulin resistance with modulation of gut microbiota in mice"],"prefix":"10.1016","volume":"86","author":[{"given":"Haizhao","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2021.111176_bib0001","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despres","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nut.2021.111176_bib0002","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11154-020-09572-7","article-title":"Microbiome response to diet: focus on obesity and related diseases","volume":"21","author":"Delzenne","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.nut.2021.111176_bib0003","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nut.2013.05.021","article-title":"Birth weight predicts the risk of gestational diabetes mellitus and pregravid obesity","volume":"30","author":"Ogonowski","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111176_bib0004","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11936-010-0080-y","article-title":"Therapeutic approaches to obesity","volume":"12","author":"Powell","year":"2010","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.nut.2021.111176_bib0005","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial metabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.nut.2021.111176_bib0006","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/jn\/nxaa124","article-title":"Nondigestible carbohydrates affect metabolic health and gut microbiota in overweight adults after weight loss","volume":"150","author":"Johnstone","year":"2020","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2021.111176_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/science.1237439","article-title":"The long-term stability of the human gut microbiota","volume":"341","author":"Faith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nut.2021.111176_bib0008","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.nut.2021.111176_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2020.110749","article-title":"Gut microbiota composition after diet and probiotics in overweight breast cancer survivors: a randomized open-label pilot intervention trial","volume":"74","author":"Pellegrini","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111176_bib0010","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3389\/fphar.2020.01300","article-title":"The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action","volume":"11","author":"Salehi","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nut.2021.111176_bib0011","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1021\/jf0609779","article-title":"Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (acai)","volume":"54","author":"Schauss","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nut.2021.111176_bib0012","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/15287394.2014.880392","article-title":"Anthocyanin-rich a\u00e7a\u00ed (Euterpe oleracea Mart.) extract attenuates manganese-induced oxidative stress in rat primary astrocyte cultures","volume":"77","author":"da Silva Santos","year":"2014","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.nut.2021.111176_bib0013","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/jphp.13290","article-title":"A\u00e7a\u00ed berries (Euterpe oleracea Mart.) dried extract improves ethanol-induced ulcer in rats","volume":"72","author":"Cury","year":"2020","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.nut.2021.111176_bib0014","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jff.2016.08.012","article-title":"Anthocyanin-rich extract of Acai (Euterpe precatoria Mart.) mediates neuroprotective activities in Caenorhabditis elegans","volume":"26","author":"Peixoto","year":"2016","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nut.2021.111176_bib0015","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/acs.jafc.5b05812","article-title":"An anthocyanin-rich extract of acai (Euterpe precatoria Mart.) increases stress resistance and retards aging-related markers in Caenorhabditis elegans","volume":"64","author":"Peixoto","year":"2016","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nut.2021.111176_bib0016","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1021\/jf501808a","article-title":"Interplay between anthocyanins and gut microbiota","volume":"62","author":"Faria","year":"2014","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nut.2021.111176_bib0017","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/en.2005-1132","article-title":"Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression","volume":"147","author":"Patsouris","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.nut.2021.111176_bib0018","first-page":"351","article-title":"Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease","volume":"20","author":"Kohjima","year":"2007","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nut.2021.111176_bib0019","doi-asserted-by":"crossref","first-page":"11957","DOI":"10.1021\/acs.jafc.8b04819","article-title":"Tea polypeptide ameliorates diabetic nephropathy through RAGE and NF-\u03baB Signaling pathway in type 2 diabetes mice","volume":"66","author":"Deng","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nut.2021.111176_bib0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2021.111176_bib0021","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.nut.2021.111176_bib0022","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.nut.2009.09.007","article-title":"Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats","volume":"26","author":"de Souza","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111176_bib0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2891-10-45","article-title":"Effects of A\u00e7ai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study","volume":"10","author":"Udani","year":"2011","journal-title":"Nutr J"},{"key":"10.1016\/j.nut.2021.111176_bib0024","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.nut.2021.111176_bib0025","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.foodres.2018.05.043","article-title":"A\u00e7ai (Euterpe oleracea Mart.) seed flour prevents obesity-induced hepatic steatosis regulating lipid metabolism by increasing cholesterol excretion in high-fat diet-fed mice","volume":"111","author":"da Silva","year":"2018","journal-title":"Food Res Int"},{"key":"10.1016\/j.nut.2021.111176_bib0026","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.lfs.2019.04.051","article-title":"Antiadipogenic effects of a\u00e7ai seed extract on high fat diet-fed mice and 3T3-L1 adipocytes: a potential mechanism of action","volume":"228","author":"Trindade","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.nut.2021.111176_bib0027","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s00394-019-02040-2","article-title":"A\u00e7a\u00ed (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring","volume":"59","author":"Barbosa","year":"2020","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nut.2021.111176_bib0028","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nut.2021.111176_bib0029","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nut.2021.111176_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/17474124.2019.1543023","article-title":"Obesity, diabetes, and the gut microbiome: an updated review","volume":"13","author":"Singer-Englar","year":"2019","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.nut.2021.111176_bib0031","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.nut.2021.111176_bib0032","first-page":"1","article-title":"Composition, diversity and abundance of gut microbiome in prediabetes and type 2 diabetes","volume":"2","author":"Lambeth","year":"2015","journal-title":"J Diabetes Obes"},{"key":"10.1016\/j.nut.2021.111176_bib0033","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ismej.2012.153","article-title":"An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice","volume":"7","author":"Fei","year":"2013","journal-title":"ISME J"},{"key":"10.1016\/j.nut.2021.111176_bib0034","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jff.2017.03.045","article-title":"Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies","volume":"33","author":"Zhou","year":"2017","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nut.2021.111176_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.12.028","article-title":"Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.nut.2021.111176_bib0036","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/mi.2016.42","article-title":"Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice","volume":"10","author":"Yang","year":"2017","journal-title":"Mucosal Immunol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:14:58Z","timestamp":1760271298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900721000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":36,"alternative-id":["S0899900721000381"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2021.111176","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary anthocyanin-rich extract of a\u00e7ai protects from diet-induced obesity, liver steatosis, and insulin resistance with modulation of gut microbiota in mice","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2021.111176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111176"}}