{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:24:56Z","timestamp":1790425496386,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["18KPHDSF00140"],"award-info":[{"award-number":["18KPHDSF00140"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602859"],"award-info":[{"award-number":["81602859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000305"],"award-info":[{"award-number":["2016YFC1000305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.nut.2021.111191","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T03:49:56Z","timestamp":1613015396000},"page":"111191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Maternal vitamin D deficiency increases the risk of obesity in male offspring mice by affecting the immune response"],"prefix":"10.1016","volume":"87-88","author":[{"given":"Pei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxiu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2021.111191_bib0001","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00000441-200604000-00002","article-title":"Overweight and obesity: prevalence, consequences, and causes of a growing public health problem","volume":"331","author":"Wyatt","year":"2006","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.nut.2021.111191_bib0002","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2458-9-88","article-title":"The incidence of comorbidities related to obesity and over weight: a systematic review and meta analysis","volume":"9","author":"Guh","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1016\/j.nut.2021.111191_bib0003","first-page":"898","article-title":"Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition","volume":"113","author":"Poirier","year":"2006","journal-title":"Physical Activity, and Metabolism. Circulation"},{"key":"10.1016\/j.nut.2021.111191_bib0004","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/obr.12439","article-title":"Effect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trials","volume":"17","author":"Eichelmann","year":"2016","journal-title":"Obes Rev"},{"key":"10.1016\/j.nut.2021.111191_bib0005","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes role of free fatty acids and tumor necrosis factor","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nut.2021.111191_bib0006","doi-asserted-by":"crossref","first-page":"21695","DOI":"10.1074\/jbc.M701419200","article-title":"Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-\u03b1 (TNF-\u03b1) expression via ERK1\/2 activation and egr-1 expression: role of TNF-\u03b1 in adiponectin-stimulated interleukin-10 production","volume":"282","author":"Park","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2021.111191_bib0007","doi-asserted-by":"crossref","first-page":"13460","DOI":"10.1074\/jbc.M110.204644","article-title":"Molecular mechanism for adiponectin-dependent M2 macrophage polarization link between the metabolic and innate immune activity of full-length adiponectin","volume":"286","author":"Mandal","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2021.111191_bib0008","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype","volume":"289","author":"Freemerman","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2021.111191_bib0009","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cmet.2017.07.020","article-title":"The lymphatic vasculature: its role in adipose metabolism and obesity","volume":"26","author":"Escobedo","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2021.111191_bib0010","doi-asserted-by":"crossref","first-page":"15333","DOI":"10.1074\/jbc.M110.100263","article-title":"Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice","volume":"285","author":"Li","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nut.2021.111191_bib0011","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/ars.2017.7060","article-title":"Metabolic regulation of adipose tissue macrophage function in obesity and diabetes","volume":"29","author":"Appari","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.nut.2021.111191_bib0012","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.metabol.2017.04.005","article-title":"Macrophage functions in lean and obese adipose tissue","volume":"72","author":"Thomas","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.nut.2021.111191_bib0013","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1517\/14728222.2014.991311","article-title":"Adipose tissue macrophages: the inflammatory link between obesity and cancer?","volume":"19","author":"Wagner","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.nut.2021.111191_bib0014","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/intimm\/dxx003","article-title":"Inflammatory and anti-inflammatory states of adipose tissue in transgenic mice bearing a single TCR","volume":"29","author":"Matsumoto","year":"2017","journal-title":"Int Immunol"},{"key":"10.1016\/j.nut.2021.111191_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11695-007-9315-8","article-title":"Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls","volume":"18","author":"Goldner","year":"2008","journal-title":"Obes Surg"},{"key":"10.1016\/j.nut.2021.111191_bib0016","first-page":"145","article-title":"Hypovitaminosis D and incidence of obesity: a prospective study","volume":"18","author":"Gonzalez-Molero","year":"2008","journal-title":"Obes Surg"},{"key":"10.1016\/j.nut.2021.111191_bib0017","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11154-011-9197-x","article-title":"Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption","volume":"13","author":"Christakos","year":"2012","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.nut.2021.111191_bib0018","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1681\/ASN.2010020186","article-title":"The regulation of parathyroid hormone secretion and synthesis","volume":"22","author":"Kumar","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nut.2021.111191_bib0019","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1113\/jphysiol.2014.273979","article-title":"Regulation of serum phosphate","volume":"592","author":"Lederer","year":"2014","journal-title":"J Physiol"},{"key":"10.1016\/j.nut.2021.111191_bib0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/bonekey.2013.233","article-title":"Vitamin D: direct effects of vitamin D metabolites on bone: lessons from genetically modified mice","volume":"3","author":"Eisman","year":"2014","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.nut.2021.111191_bib0021","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jaci.2017.02.039","article-title":"Vitamin D supplementation during pregnancy: effect on the neonatal immune system in a randomized controlled trial","volume":"141","author":"Hornsby","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.nut.2021.111191_bib0022","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jnutbio.2007.05.013","article-title":"Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk","volume":"19","author":"Sun","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2021.111191_bib0023","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/nu9040338","article-title":"Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK\/SIRT1 activity in obese rats","volume":"9","author":"Chang","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2021.111191_bib0024","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tem.2008.10.006","article-title":"Early-life origins of metabolic dysfunction: role of the adipocyte","volume":"20","author":"Muhlhausler","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.nut.2021.111191_bib0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1139\/cjpp-2012-0353","article-title":"Nutritional approaches to breaking the intergenerational cycle of obesity","volume":"91","author":"Muhlhausler","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.nut.2021.111191_bib0026","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.earlhumdev.2008.10.006","article-title":"Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight","volume":"85","author":"Theresa","year":"2009","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.nut.2021.111191_bib0027","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2013.11.003","article-title":"Is vitamin D deficiency a major global public health problem?","volume":"144","author":"Palacios","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.nut.2021.111191_bib0028","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1017\/S0007114516000623","article-title":"The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort study","volume":"116","author":"Ong","year":"2016","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nut.2021.111191_bib0029","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.mehy.2008.01.033","article-title":"Maternal vitamin D in pregnancy may influence not only offspring bone mass but other aspects of musculoskeletal health and adiposity","volume":"71","author":"Pasco","year":"2008","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.nut.2021.111191_bib0030","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00394-016-1359-x","article-title":"Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPAR\u03b3) and vitamin D receptor (VDR) in lean male mice offspring","volume":"57","author":"Belenchia","year":"2018","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nut.2021.111191_bib0031","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3390\/nu8110675","article-title":"Maternal dietary vitamin D does not program systemic inflammation and bone health in adult female mice fed an obesogenic diet","volume":"8","author":"Villa","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2021.111191_bib0032","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/CIRCULATIONAHA.117.030088","article-title":"Low-calorie vegetarian versus Mediterranean diets for reducing body weight and improving cardiovascular risk profile: CARDIVEG Study (Cardiovascular Prevention With Vegetarian Diet)","volume":"137","author":"Sofi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.nut.2021.111191_bib0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jsbmb.2018.04.009","article-title":"Fetuin B links vitamin D deficiency and pediatric obesity: direct negative regulation by vitamin D","volume":"182","author":"Walker","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.nut.2021.111191_bib0034","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/JOE-17-0015","article-title":"In utero vitamin D deficiency predisposes offspring to long-term adverse adipose tissue effects","volume":"234","author":"Belenchia","year":"2017","journal-title":"J Endocrinol"},{"key":"10.1016\/j.nut.2021.111191_bib0035","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/jcp.24371","article-title":"Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue","volume":"228","author":"Narvaez","year":"2013","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nut.2021.111191_bib0036","first-page":"96","article-title":"Inflammatory features of obesity and smoke exposure and the immunologic effects of exercise","volume":"25","author":"Batatinha","year":"2019","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.nut.2021.111191_bib0037","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s40618-018-0872-6","article-title":"From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome","volume":"41","author":"Maiorino","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.nut.2021.111191_bib0038","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/joim.12803","article-title":"Inflammation of brown\/beige adipose tissues in obesity and metabolic disease","volume":"284","author":"Villarroya","year":"2018","journal-title":"J Intern Med"},{"key":"10.1016\/j.nut.2021.111191_bib0039","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/01635581.2017.1263346","article-title":"Vitamin D reduces colitis- and inflammation-associated colorectal cancer in mice independent of NOD2","volume":"69","author":"Elimrani","year":"2017","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.nut.2021.111191_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-nutr-071812-161113","article-title":"Macrophages and the regulation of adipose tissue remodeling","volume":"34","author":"Martinez-Santiba\u00f1ez","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.nut.2021.111191_bib0041","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/sj.ijo.0803744","article-title":"Obesity in C57BL\/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration","volume":"32","author":"Rausch","year":"2008","journal-title":"Int J Obes"},{"key":"10.1016\/j.nut.2021.111191_bib0042","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.nut.2021.111191_bib0043","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cmet.2015.03.001","article-title":"Regulation of obesity-related insulin resistance with gut anti-inflammatory agents","volume":"21","author":"Luck","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2021.111191_bib0044","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.immuni.2015.08.015","article-title":"Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity","volume":"43","author":"Zlotnikov-Klionsky","year":"2015","journal-title":"Immunity"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:12:55Z","timestamp":1760271175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900721000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":44,"alternative-id":["S0899900721000538"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2021.111191","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.23.004721","asserted-by":"object"}]},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal vitamin D deficiency increases the risk of obesity in male offspring mice by affecting the immune response","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2021.111191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111191"}}