{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:59:52Z","timestamp":1790495992859,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.nut.2021.111274","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T21:50:55Z","timestamp":1618955455000},"page":"111274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Fecal microbiota from children with vitamin A deficiency impair colonic barrier function in germ-free mice: The possible role of alterative bile acid metabolites"],"prefix":"10.1016","volume":"90","author":[{"given":"Di","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2021.111274_bib0001","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1124\/mol.106.029579","article-title":"Cellular retinoic acid bioavailability determines epithelial integrity: role of retinoic acid receptor \u03b1 agonists in colitis","volume":"71","author":"Osanai","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.nut.2021.111274_bib0002","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.nut.2013.09.008","article-title":"Gestational vitamin A deficiency reduces the intestinal immune response by decreasing the number of immune cells in rat offspring","volume":"30","author":"Liu","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111274_bib0003","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2011.03.003","article-title":"Essential role for retinoic acid in the promotion of CD4+ T cell effector responses via retinoic acid receptor alpha","volume":"34","author":"Hall","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.nut.2021.111274_bib0004","series-title":"Coverage at a crossroads: new directions for vitamin A supplementation programmes","author":"UNICEF","year":"2018"},{"key":"10.1016\/j.nut.2021.111274_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arcmed.2018.04.003","article-title":"Vitamin A and retinoic acid exhibit protective effects on necrotizing enterocolitis by regulating intestinal flora and enhancing the intestinal epithelial barrier","volume":"49","author":"Xiao","year":"2018","journal-title":"Arch Med Res"},{"key":"10.1016\/j.nut.2021.111274_bib0006","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1039\/C8FO01123K","article-title":"Vitamin A inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins","volume":"10","author":"He","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.nut.2021.111274_bib0007","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jnutbio.2008.01.002","article-title":"Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet","volume":"20","author":"Amit-Romach","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2021.111274_bib0008","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/nu10091128","article-title":"Modulation of intestinal immune and barrier functions by vitamin a: implications for current understanding of malnutrition and enteric infections in children","volume":"10","author":"de Medeiros","year":"2018","journal-title":"Nutrients"},{"issue":"5728","key":"10.1016\/j.nut.2021.111274_bib0009","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.nut.2021.111274_bib0010","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/mi.2016.114","article-title":"Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43","volume":"10","author":"Wu","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0011","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1078\/0171-2985-00052","article-title":"Tlaskalov\u00e1-Hogenov\u00e1 H. Specific antibody and immunoglobulin responses after intestinal colonization of germ-free piglets with non-pathogenic Escherichia coli 086","volume":"204","author":"Cukrowska","year":"2001","journal-title":"Immunobiology"},{"key":"10.1016\/j.nut.2021.111274_bib0012","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cmi.2010.67","article-title":"The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases","volume":"8","author":"Tlaskalov\u00e1-Hogenov\u00e1","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0013","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jnutbio.2017.10.011","article-title":"Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis","volume":"54","author":"Tian","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2021.111274_bib0014","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3164\/jcbn.15-148","article-title":"Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea","volume":"59","author":"Lv","year":"2016","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.nut.2021.111274_bib0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nut.2018.06.007","article-title":"Vitamin A supplementation improves the intestinal mucosal barrier and facilitates the expression of tight junction proteins in rats with diarrhea","volume":"57","author":"Xiao","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111274_bib0016","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fmicb.2019.00268","article-title":"TLR4 may be involved in the regulation of colonic mucosal microbiota by vitamin A","volume":"10","author":"Xiao","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.nut.2021.111274_bib0017","doi-asserted-by":"crossref","first-page":"eaau8317","DOI":"10.1126\/sciadv.aau8317","article-title":"The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice","volume":"5","author":"Zheng","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.nut.2021.111274_bib0018","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nut.2021.111274_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.nut.2021.111274_bib0020","doi-asserted-by":"crossref","first-page":"eaal4069","DOI":"10.1126\/scitranslmed.aal4069","article-title":"The effects of micronutrient deficiencies on bacterial species from the human gut microbiota","volume":"9","author":"Hibberd","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.nut.2021.111274_bib0021","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/19490976.2017.1353842","article-title":"New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota","volume":"8","author":"Lee","year":"2017","journal-title":"Gut Microbes"},{"key":"10.1016\/j.nut.2021.111274_bib0022","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1172\/JCI110881","article-title":"Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat","volume":"71","author":"Luk","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2021.111274_bib0023","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-immunol-051116-052424","article-title":"Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing","volume":"35","author":"Kurashima","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0024","first-page":"G467","article-title":"Tight junctions and the molecular basis for regulation of paracellular permeability","volume":"269","author":"Anderson","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nut.2021.111274_bib0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0962-8924(99)01578-0","article-title":"Occludin and claudins in tight-junction strands: leading or supporting players?","volume":"9","author":"Tsukita","year":"1999","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.nut.2021.111274_bib0026","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0027","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.4049\/jimmunol.1500989","article-title":"Cutting edge: retinoic acid signaling in B cells is essential for oral immunization and microflora composition","volume":"195","author":"Pantazi","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0028","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/CMR.00008-07","article-title":"Bacteroides: the good, the bad, and the nitty-gritty","volume":"20","author":"Wexler","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.nut.2021.111274_bib0029","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.nutres.2015.11.014","article-title":"Bifidobacterium lactis 420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells","volume":"36","author":"Mokkala","year":"2016","journal-title":"Nutr Res"},{"key":"10.1016\/j.nut.2021.111274_bib0030","doi-asserted-by":"crossref","first-page":"e01202","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.nut.2021.111274_bib0031","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/mi.2015.33","article-title":"Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection","volume":"9","author":"Dillon","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.nut.2021.111274_bib0032","first-page":"1","article-title":"Metabolic and functional interplay between gut microbiota and fat-soluble vitamins","author":"Stacchiotti","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.nut.2021.111274_bib0033","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1080\/10408398.2018.1546670","article-title":"Insights into the role of bacteria in vitamin A biosynthesis: future research opportunities","volume":"59","author":"Srinivasan","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.nut.2021.111274_bib0034","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.immuni.2018.11.018","article-title":"Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis","volume":"49","author":"Grizotte-Lake","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.nut.2021.111274_bib0035","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.1224203","article-title":"The application of ecological theory toward an understanding of the human microbiome","volume":"336","author":"Costello","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.nut.2021.111274_bib0036","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.nut.2021.111274_bib0037","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/pr100896s","article-title":"Are patients with potential celiac disease really potential? The answer of metabonomics","volume":"10","author":"Bernini","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.nut.2021.111274_bib0038","doi-asserted-by":"crossref","first-page":"e25637","DOI":"10.1371\/journal.pone.0025637","article-title":"The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis","volume":"6","author":"Cipriani","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nut.2021.111274_bib0039","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.surg.2003.08.025","article-title":"Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression","volume":"135","author":"Yamaguchi","year":"2004","journal-title":"Surgery"},{"key":"10.1016\/j.nut.2021.111274_bib0040","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/bjs.1800631011","article-title":"Endotoxin, bile salts and renal function in obstructive jaundice","volume":"63","author":"Bailey","year":"1976","journal-title":"Br J Surg"},{"key":"10.1016\/j.nut.2021.111274_bib0041","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s40168-018-0510-8","article-title":"The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism","volume":"6","author":"Just","year":"2018","journal-title":"Microbiome"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721001362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721001362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:16:03Z","timestamp":1760271363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900721001362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"alternative-id":["S0899900721001362"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2021.111274","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fecal microbiota from children with vitamin A deficiency impair colonic barrier function in germ-free mice: The possible role of alterative bile acid metabolites","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2021.111274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111274"}}