{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:06:27Z","timestamp":1776107187772,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100013201","name":"Cargill Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013201","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004387","name":"Cargill Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.nut.2021.111296","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T02:40:38Z","timestamp":1619577638000},"page":"111296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Vitamin D supplementation reduces serum lipids of children with hypertriacylglycerolemia: A randomized, triple-masked, placebo-controlled crossover trial"],"prefix":"10.1016","volume":"89","author":[{"given":"Ana Gabriella P.","family":"Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz A.C.","family":"Cruvinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-6775","authenticated-orcid":false,"given":"Raquel M.","family":"Schincaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo S.","family":"Godoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2021.111296_bib0001","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.nut.2021.111296_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fped.2014.00073","article-title":"The role of infant nutrition in the prevention of future disease","volume":"2","author":"Elenberg","year":"2014","journal-title":"Front Pediatr"},{"key":"10.1016\/j.nut.2021.111296_bib0003","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1001\/jama.2012.14312","article-title":"Lifetime risk and years lived free of total cardiovascular disease","volume":"308","author":"Wilkins","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.nut.2021.111296_bib0004","first-page":"1","article-title":"Vitamin D deficiency associated with markers of cardiovascular disease in children with obesity","volume":"5","author":"Censani","year":"2018","journal-title":"Glob Pediatr Health"},{"key":"10.1016\/j.nut.2021.111296_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo9070125","article-title":"Relationship between vitamin D level and lipid profile in non-obese children","volume":"9","author":"Kim","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.nut.2021.111296_bib0006","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nut.2021.111296_bib0007","first-page":"1","article-title":"The risks and benefits of sun exposure 2016","volume":"0","author":"Hoel","year":"2016","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.nut.2021.111296_bib0008","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ajcn\/88.2.582S","article-title":"Pharmacokinetics of vitamin D toxicity","volume":"88","author":"Jones","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0009","series-title":"Bioequivalence studies with pharmacokinetic endpoints for drugs submitted under an ANDA","year":"2013"},{"key":"10.1016\/j.nut.2021.111296_bib0010","first-page":"139","article-title":"Vitamin D supplementation: Guidelines and evidence for subclinical deficiency","volume":"28","author":"Pramyothin","year":"2012","journal-title":"Society"},{"key":"10.1016\/j.nut.2021.111296_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/abc.20170121","article-title":"Atualiza\u00e7\u00e3o da diretriz brasileira de dislipidemias e preven\u00e7\u00e3o da aterosclerose - 2017","volume":"109","author":"Faludi","year":"2017","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.nut.2021.111296_bib0012","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000362449","article-title":"Effect of vitamin D3 supplementation on serum 25(OH)D, lipids and markers of insulin resistance in obese adolescents: A prospective, randomized, placebo-controlled pilot trial","volume":"82","author":"Nader","year":"2014","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.nut.2021.111296_bib0013","doi-asserted-by":"crossref","DOI":"10.1177\/0009922817706975","article-title":"Chemical and common burns in children","volume":"56","author":"Yin","year":"2017","journal-title":"Clin Pediatr"},{"key":"10.1016\/j.nut.2021.111296_bib0014","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/ped.12092","article-title":"Physical Activity Questionnaire for children and adolescents: English norms and cut-off points","volume":"55","author":"Voss","year":"2013","journal-title":"Pediatr Int"},{"key":"10.1016\/j.nut.2021.111296_bib0015","unstructured":"World Health Organization. BMI-for-age (5\u201319 years). Available at: https:\/\/www.who.int\/toolkits\/growth-reference-data-for-5to19-years\/indicators\/bmi-for-age. Accessed March 4, 2021."},{"key":"10.1016\/j.nut.2021.111296_bib0016","series-title":"International standards for anthropometric assessment","year":"2011"},{"key":"10.1016\/j.nut.2021.111296_bib0017","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jpeds.2004.06.044","article-title":"Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents","volume":"145","author":"Fern\u00e1ndez","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.nut.2021.111296_bib0018","first-page":"1","article-title":"Waist-to-height ratio (WHR): Proposed approach to establishing reference values for children and youths","volume":"22","author":"Stupnicki","year":"2013","journal-title":"Pap Anthropol"},{"key":"10.1016\/j.nut.2021.111296_bib0019","first-page":"1","article-title":"7a diretriz brasileira de hipertens\u00e3o arterial","volume":"107","author":"Malachias","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.nut.2021.111296_bib0020","series-title":"Dietary reference intakes for calcium and vitamin D","year":"2011"},{"key":"10.1016\/j.nut.2021.111296_bib0021","series-title":"Fundamentals of biostatistics","author":"Rosner","year":"2011"},{"key":"10.1016\/j.nut.2021.111296_bib0022","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size\u2014or why the P value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J Grad Med Educ"},{"key":"10.1016\/j.nut.2021.111296_bib0023","first-page":"1","article-title":"Effect of vitamin D supplementation on serum lipid profiles: A systematic review and meta-analysis","volume":"0","author":"Dibaba","year":"2019","journal-title":"Nutr Rev"},{"key":"10.1016\/j.nut.2021.111296_bib0024","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/09637486.2014.886186","article-title":"Association between vitamin D status and lipid profile in children and adolescents: A systematic review and meta-analysis","volume":"65","author":"Kelishadi","year":"2014","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0025","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1161\/CIRCULATIONAHA.118.034273","article-title":"Long-term association of low-density lipoprotein cholesterol with cardiovascular mortality in individuals at low 10-year risk of atherosclerotic cardiovascular disease: Results from the Cooper Center Longitudinal study","volume":"138","author":"Abdullah","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.nut.2021.111296_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.118.008819","article-title":"Effect of change in total cholesterol levels on cardiovascular disease among young adults","volume":"7","author":"Jeong","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.nut.2021.111296_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-019-1080-x","article-title":"Evidence for changing lipid management strategy to focus on non-high density lipoprotein cholesterol","volume":"18","author":"Su","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nut.2021.111296_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0131938","article-title":"Association between vitamin D and circulating lipids in early childhood","volume":"10","author":"Birken","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2021.111296_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0186196","article-title":"Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study","volume":"12","author":"Orozco-Beltran","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2021.111296_bib0030","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1017\/S1368980014002286","article-title":"Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status","volume":"18","author":"Jungert","year":"2015","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0031","doi-asserted-by":"crossref","first-page":"600","DOI":"10.5551\/jat.37184","article-title":"Is high serum LDL\/HDL cholesterol ratio an emerging risk factor for sudden cardiac death? Findings from the KIHD study","volume":"24","author":"Kunutsor","year":"2017","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.nut.2021.111296_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-018-0800-y","article-title":"Comparison of various lipid parameters in association of target organ damage: A cohort study","volume":"17","author":"Chi","year":"2018","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nut.2021.111296_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0090497","article-title":"The LDL-HDL profile determines the risk of atherosclerosis: A mathematical model","volume":"9","author":"Hao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2021.111296_bib0034","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0002-8703(03)00516-7","article-title":"Risk determination of dyslipidemia in populations characterized by low levels of high-density lipoprotein cholesterol","volume":"146","author":"Bersot","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.nut.2021.111296_bib0035","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0002-9149(88)90558-9","article-title":"Contributions of the Framingham study to the conquest of coronary artery disease","volume":"62","author":"Kannel","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nut.2021.111296_bib0036","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mnfr.201500425","article-title":"Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2\/SREBP-2 pathway","volume":"60","author":"Li","year":"2016","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.nut.2021.111296_bib0037","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/sj.ijo.0803660","article-title":"An intervention study of the effects of calcium intake on faecal fat excretion, energy metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins","volume":"31","author":"Boon","year":"2007","journal-title":"Int J Obes"},{"key":"10.1016\/j.nut.2021.111296_bib0038","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00394-019-02150-x","article-title":"Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: A systematic review and meta-analysis of randomized controlled trials","volume":"59","author":"Hauger","year":"2020","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0039","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s40618-018-0840-1","article-title":"Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children","volume":"41","author":"Gannag\u00e9-Yared","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.nut.2021.111296_bib0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3122\/jabfm.2016.02.150251","article-title":"Probability of vitamin D deficiency by body weight and race\/ethnicity","volume":"29","author":"Weishaar","year":"2016","journal-title":"J Am Board Fam Med"},{"key":"10.1016\/j.nut.2021.111296_bib0041","series-title":"Pesquisa de Or\u00e7amentos Familiares 2008\u20132009: An\u00e1lise do consumo alimentar pessoal no Brasil","year":"2011"},{"key":"10.1016\/j.nut.2021.111296_bib0042","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/nbu.12108","article-title":"Vitamin D: An overview of vitamin D status and intake in Europe","volume":"39","author":"Spiro","year":"2014","journal-title":"Nutr Bull"},{"key":"10.1016\/j.nut.2021.111296_bib0043","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/ajcn\/nqz037","article-title":"Vitamin D status in the United States, 2011\u20132014","volume":"110","author":"Herrick","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0044","series-title":"Nutrients: Vitamin D (IU)","year":"2018"},{"key":"10.1016\/j.nut.2021.111296_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacl.2015.09.002","article-title":"National lipid association recommendations for patient-centered management of dyslipidemia: Part 2","volume":"9","author":"Jacobson","year":"2015","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.nut.2021.111296_bib0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3549402","article-title":"Vitamin D serum levels in patients with statin-induced musculoskeletal pain","volume":"2019","author":"Pennisi","year":"2019","journal-title":"Dis Markers"},{"key":"10.1016\/j.nut.2021.111296_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-1840-4","article-title":"Vitamin D and growth hormone in children: A review of the current scientific knowledge","volume":"17","author":"Esposito","year":"2019","journal-title":"J Transl Med"},{"key":"10.1016\/j.nut.2021.111296_bib0048","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/07315724.2015.1039866","article-title":"Sunlight and vitamin D: Necessary for public health","volume":"34","author":"Baggerly","year":"2015","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.nut.2021.111296_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11081857","article-title":"The role of water homeostasis in muscle function and frailty: A review","volume":"11","author":"Lorenzo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2021.111296_bib0050","unstructured":"World Health Organization. Growth reference data for 5\u201319 years. Available at: https:\/\/www.who.int\/growthref\/en\/. Accessed April 19, 2020."},{"key":"10.1016\/j.nut.2021.111296_bib0051","first-page":"693","article-title":"High blood pressure in children and adolescents","volume":"85","author":"Riley","year":"2012","journal-title":"Am Fam Physician"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721001581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721001581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:17:46Z","timestamp":1760271466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900721001581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":51,"alternative-id":["S0899900721001581"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2021.111296","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D supplementation reduces serum lipids of children with hypertriacylglycerolemia: A randomized, triple-masked, placebo-controlled crossover trial","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2021.111296","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111296"}}