{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:14:14Z","timestamp":1761808454475,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K11553","20K11364"],"award-info":[{"award-number":["19K11553","20K11364"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.nut.2021.111389","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T11:23:15Z","timestamp":1623496995000},"page":"111389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Basal and resistance exercise-induced increase in protein synthesis is impaired in skeletal muscle of iron-deficient rats"],"prefix":"10.1016","volume":"91-92","author":[{"given":"Kazuhiko","family":"Higashida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachika","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nodoka","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-2576","authenticated-orcid":false,"given":"Naoya","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2021.111389_bib0001","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"McLean","year":"2009","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0002","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/59.5.1233S","article-title":"Iron status of vegetarians","volume":"59","author":"Craig","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0003","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/07315724.1990.10720415","article-title":"Long-term effects of a vegetarian diet on the nutritional status of elderly people (Dutch Nutrition Surveillance System)","volume":"9","author":"L\u00f6wik","year":"1990","journal-title":"J Am College Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0004","first-page":"E418","article-title":"Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion","volume":"242","author":"Davies","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/gerona\/59.3.M249","article-title":"Hemoglobin levels and skeletal muscle: results from the InCHIANTI study","volume":"59","author":"Cesari","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.nut.2021.111389_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41430-020-00742-z","article-title":"Iron deficiency, fatigue and muscle strength and function in older hospitalized patients","volume":"75","author":"Neidlein","year":"2021","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0007","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/112_2013_17","article-title":"The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli","volume":"166","author":"Goodman","year":"2014","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.nut.2021.111389_bib0008","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.nut.2021.111389_bib0009","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","article-title":"Twenty-five years of mTOR: Uncovering the link from nutrients to growth","volume":"114","author":"Sabatini","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nut.2021.111389_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2020.110795","article-title":"Habitual high-protein diet does not influence muscle protein synthesis in response to acute resistance exercise in rats","volume":"78","author":"Ato","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.nut.2021.111389_bib0011","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphys.2015.00245","article-title":"Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy","volume":"6","author":"Morton","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0012","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1113\/jphysiol.2012.228833","article-title":"Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men","volume":"590","author":"Churchward-Venne","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0013","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbrc.2020.07.041","article-title":"Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes","volume":"531","author":"Higashida","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nut.2021.111389_bib0014","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1113\/jphysiol.2010.192856","article-title":"Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men","volume":"588","author":"Burd","year":"2010","journal-title":"J Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0015","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2005.10.024","article-title":"mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events","volume":"123","author":"Holz","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.nut.2021.111389_bib0016","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1097-2765(01)80003-4","article-title":"Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G","volume":"3","author":"Marcotrigiano","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.nut.2021.111389_bib0017","doi-asserted-by":"crossref","first-page":"31142","DOI":"10.1038\/srep31142","article-title":"The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise","volume":"6","author":"Ogasawara","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.nut.2021.111389_bib0018","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1113\/JP271365","article-title":"Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle","volume":"594","author":"West","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0019","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1152\/japplphysiol.00578.2019","article-title":"High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis","volume":"128","author":"Maruyama","year":"2020","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.nut.2021.111389_bib0020","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fphys.2019.00406","article-title":"The effect of changing the contraction mode during resistance training on mTORC1 signaling and muscle protein synthesis","volume":"10","author":"Ato","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.nut.2021.111389_bib0021","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1152\/jappl.1990.69.5.1718","article-title":"Protein metabolism in rat tibialis anterior muscle after stimulated chronic eccentric exercise","volume":"69","author":"Wong","year":"1990","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.nut.2021.111389_bib0022","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/pr1011476","article-title":"Coomassie staining as loading control in Western blot analysis","volume":"10","author":"Welinder","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.nut.2021.111389_bib0023","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1096\/fj.10-168799","article-title":"Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique","volume":"25","author":"Goodman","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2021.111389_bib0024","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3945\/jn.108.093757","article-title":"Severe iron deficiency decreases both bone formation and bone resorption in rats","volume":"139","author":"Katsumata","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0025","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/jn\/134.11.3061","article-title":"Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight","volume":"134","author":"Medeiros","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.nut.2021.111389_bib0026","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1743-7075-9-104","article-title":"Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle","volume":"9","author":"Merrill","year":"2012","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.nut.2021.111389_bib0027","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1152\/japplphysiol.00465.2016","article-title":"Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle","volume":"121","author":"Kitaoka","year":"2016","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.nut.2021.111389_bib0028","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1152\/japplphysiol.91351.2008","article-title":"Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences","volume":"106","author":"Burd","year":"2009","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.nut.2021.111389_bib0029","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11010-015-2446-7","article-title":"Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells","volume":"406","author":"Nakai","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nut.2021.111389_bib0030","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.biocel.2013.04.023","article-title":"Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome","volume":"45","author":"Sandri","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.nut.2021.111389_bib0031","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1096\/fj.201903055R","article-title":"A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway","volume":"34","author":"Cui","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.nut.2021.111389_bib0032","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12576-017-0531-2","article-title":"Long-term resistance exercise-induced muscular hypertrophy is associated with autophagy modulation in rats","volume":"68","author":"Kwon","year":"2018","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.nut.2021.111389_bib0033","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1152\/japplphysiol.01009.2016","article-title":"Relationship between exercise volume and muscle protein synthesis in a rat model of resistance exercise","volume":"123","author":"Ogasawara","year":"2017","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.nut.2021.111389_bib0034","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.exger.2013.08.011","article-title":"Aging-related changes in the iron status of skeletal muscle","volume":"48","author":"DeRuisseau","year":"2013","journal-title":"Exp Gerontol"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721002513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900721002513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:16:24Z","timestamp":1760271384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900721002513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"alternative-id":["S0899900721002513"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2021.111389","relation":{},"ISSN":["0899-9007"],"issn-type":[{"type":"print","value":"0899-9007"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basal and resistance exercise-induced increase in protein synthesis is impaired in skeletal muscle of iron-deficient rats","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2021.111389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111389"}}