{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:33:30Z","timestamp":1786995210589,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["C26A15CMXT"],"award-info":[{"award-number":["C26A15CMXT"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.nut.2024.112643","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:30:17Z","timestamp":1731749417000},"page":"112643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Dark chocolate's impact on low-grade endotoxemia in metabolic dysfunction-associated steatohepatitis"],"prefix":"10.1016","volume":"131","author":[{"given":"Arianna","family":"Pannunzio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-8482","authenticated-orcid":false,"given":"Enrico","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria Maria","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Magna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Trivigno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartimoccia","family":"Simona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Cammisotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-5829","authenticated-orcid":false,"given":"Gianpaolo","family":"Vidili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Del","family":"Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-6235","authenticated-orcid":false,"given":"Lorenzo","family":"Loffredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2024.112643_bib0001","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.nut.2024.112643_bib0002","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1016\/j.jhep.2023.07.021","article-title":"Can we use old NAFLD data under the new MASLD definition?","volume":"80","author":"Song","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.nut.2024.112643_bib0003","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/apt.13687","article-title":"Effects of dark chocolate on NOX-2-generated oxidative stress in patients with non-alcoholic steatohepatitis","volume":"44","author":"Loffredo","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nut.2024.112643_bib0004","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased liver localization of lipopolysaccharides in human and experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.nut.2024.112643_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.numecd.2017.10.027","article-title":"Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis","volume":"28","author":"Loffredo","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.nut.2024.112643_bib0006","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/bcp.12923","article-title":"Antioxidant and antiplatelet activity by polyphenol-rich nutrients: focus on extra virgin olive oil and cocoa","volume":"83","author":"Loffredo","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.nut.2024.112643_bib0007","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/nu15194203","article-title":"Dark chocolate intake positively modulates gut permeability in elite football athletes: a randomized controlled study","volume":"15","author":"Nocella","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2024.112643_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2020.101611","article-title":"Association between gut permeability and insulin resistance: any role for zonulin in patients with non-alcoholic fatty liver disease?","volume":"45","author":"Rosso","year":"2021","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.nut.2024.112643_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7906927","article-title":"Cocobiota: implications for human health","volume":"2016","author":"Petyaev","year":"2016","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.nut.2024.112643_bib0010","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0140-6736(00)02169-3","article-title":"Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease","volume":"355","author":"Fasano","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.nut.2024.112643_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108618","article-title":"Dietary cocoa ameliorates non-alcoholic fatty liver disease and increases markers of antioxidant response and mitochondrial biogenesis in high fat-fed mice","volume":"92","author":"Sun","year":"2021","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2024.112643_bib0012","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jnutbio.2013.12.004","article-title":"Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice","volume":"25","author":"Gu","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nut.2024.112643_bib0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/nu12071908","article-title":"Cocoa polyphenols and gut microbiota interplay: bioavailability, prebiotic effect, and impact on human health","volume":"12","author":"Sorrenti","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2024.112643_bib0014","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.foodcont.2015.01.014","article-title":"Metabolites produced during the growth of probiotics in cocoa supplementation and the limited role of cocoa in host-enteric bacterial pathogen interactions","volume":"53","author":"Peng","year":"2015","journal-title":"Food Control"},{"key":"10.1016\/j.nut.2024.112643_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4625279","article-title":"Prebiotic effect of lycopene and dark chocolate on gut microbiome with systemic changes in liver metabolism, skeletal muscles and skin in moderately obese persons","volume":"2019","author":"Wiese","year":"2019","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nut.2024.112643_bib0016","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1136\/heartjnl-2011-300304","article-title":"NOX2-mediated arterial dysfunction in smokers: acute effect of dark chocolate","volume":"97","author":"Loffredo","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.nut.2024.112643_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/nu15183927","article-title":"Biological properties and antimicrobial potential of cocoa and its effects on systemic and oral health","volume":"15","author":"Fideles","year":"2023","journal-title":"Nutrients"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900724002922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900724002922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:09:34Z","timestamp":1740053374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900724002922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":17,"alternative-id":["S0899900724002922"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2024.112643","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dark chocolate's impact on low-grade endotoxemia in metabolic dysfunction-associated steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2024.112643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112643"}}