{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:12:32Z","timestamp":1778548352149,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K07757"],"award-info":[{"award-number":["17K07757"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21H02139"],"award-info":[{"award-number":["21H02139"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["C22-53"],"award-info":[{"award-number":["C22-53"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.nut.2025.112792","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T10:07:23Z","timestamp":1744106843000},"page":"112792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["\u03b2-hydroxybutyrate attenuates diabetic renal and muscular pathologies in a streptozotocin-induced diabetic model"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2803-223X","authenticated-orcid":false,"given":"Rahmawati","family":"Aisyah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Katsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshu","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhgyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Horii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayane","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-5186","authenticated-orcid":false,"given":"Thanutchaporn","family":"Kumrungsee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-0822","authenticated-orcid":false,"given":"Noriyuki","family":"Yanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2025.112792_bib0001","article-title":"Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025","volume":"10","author":"Lin","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.nut.2025.112792_bib0002","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4093\/dmj.2018.0060","article-title":"Diabetes mellitus and cause-specific mortality: a population-based study","volume":"43","author":"Li","year":"2019","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.nut.2025.112792_bib0003","doi-asserted-by":"crossref","first-page":"F103","DOI":"10.1152\/ajprenal.00155.2001","article-title":"Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes","volume":"282","author":"Tuttle","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.nut.2025.112792_bib0004","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2025.112792_bib0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"The Lancet"},{"key":"10.1016\/j.nut.2025.112792_bib0006","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nut.2025.112792_bib0007","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/1753-0407.12124","article-title":"Striated muscle fiber size, composition, and capillary density in diabetes in relation to neuropathy and muscle strength","volume":"6","author":"Andreassen","year":"2014","journal-title":"J Diabetes"},{"key":"10.1016\/j.nut.2025.112792_bib0008","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1210\/clinem\/dgab261","article-title":"Impaired function and altered morphology in the skeletal muscles of adult men and women with type 1 diabetes","volume":"106","author":"Dial","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94441-9","article-title":"Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study","volume":"11","author":"Kashima","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.nut.2025.112792_bib0010","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.3390\/nu14224932","article-title":"Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer","volume":"14","author":"Hwang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2025.112792_bib0011","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0012","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-nutr-111120-111518","article-title":"Metabolic and signaling roles of ketone bodies in health and disease","volume":"41","author":"Puchalska","year":"2021","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.nut.2025.112792_bib0013","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI200318797","article-title":"D-\u03b2-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease","volume":"112","author":"Tieu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2025.112792_bib0014","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bbrc.2016.03.109","article-title":"Enhanced and suppressed mineralization by acetoacetate and \u03b2-hydroxybutyrate in osteoblast cultures","volume":"473","author":"Saito","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nut.2025.112792_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2015.11.018","article-title":"Ketones block amyloid entry and improve cognition in an Alzheimer\u2019s model","volume":"39","author":"Yin","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.nut.2025.112792_bib0016","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome\u2013mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.nut.2025.112792_bib0017","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd3777","article-title":"G protein-coupled receptors for energy metabolites as new therapeutic targets","volume":"11","author":"Blad","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nut.2025.112792_bib0018","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/pedi.13406","article-title":"ISPAD clinical practice consensus guidelines 2022: diabetic ketoacidosis and hyperglycemic hyperosmolar state","volume":"23","author":"Glaser","year":"2022","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.nut.2025.112792_bib0019","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3390\/nu12071930","article-title":"\u03b2-hydroxybutyrate increases exercise capacity associated with changes in mitochondrial function in skeletal muscle","volume":"12","author":"Monsalves-Alvarez","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.nut.2025.112792_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211005","article-title":"The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome","volume":"14","author":"Trotta","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2025.112792_bib0021","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.18632\/aging.101838","article-title":"Anti-inflammatory action of \u03b2-hydroxybutyrate via modulation of PGC-1\u03b1 and FoxO1, mimicking calorie restriction","volume":"11","author":"Kim","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.nut.2025.112792_bib0022","doi-asserted-by":"crossref","first-page":"13533","DOI":"10.1073\/pnas.1820282116","article-title":"Up-regulation of FOXO1 and reduced inflammation by \u03b2-hydroxybutyric acid are essential diet restriction benefits against liver injury","volume":"116","author":"Miyauchi","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nut.2025.112792_bib0023","first-page":"379","article-title":"Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells","volume":"4","author":"D\u2019Souza","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.nut.2025.112792_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151409","article-title":"Organ crosstalk contributes to muscle wasting in chronic kidney disease","volume":"43","author":"Wang","year":"2023","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.nut.2025.112792_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046625","article-title":"Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis","volume":"7","author":"Shikatani","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2025.112792_bib0026","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnut.2020.00013","article-title":"Metabolism of exogenous d-beta-hydroxybutyrate, an energy substrate avidly consumed by the heart and kidney","volume":"7","author":"Cuenoud","year":"2020","journal-title":"Front Nutr"},{"key":"10.1016\/j.nut.2025.112792_bib0027","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1046\/j.1523-1755.2001.00020.x","article-title":"Diabetic nephropathy: prevention and treatment","volume":"60","author":"Parving","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.nut.2025.112792_bib0028","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11892-006-0083-y","article-title":"Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history","volume":"6","author":"Rossing","year":"2006","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.nut.2025.112792_bib0029","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2438857","article-title":"Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through \u03b2-hydroxybutyrate production","volume":"47","author":"Tian","year":"2025","journal-title":"Ren Fail"},{"key":"10.1016\/j.nut.2025.112792_bib0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2016.08.022","article-title":"Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: an update","volume":"791","author":"Bhattacharjee","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nut.2025.112792_bib0031","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jaci.2007.08.046","article-title":"Epithelium: at the interface of innate and adaptive immune responses","volume":"120","author":"Schleimer","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.nut.2025.112792_bib0032","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-020-2424-4","article-title":"Structural cells are key regulators of organ-specific immune responses","volume":"583","author":"Krausgruber","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.nut.2025.112792_bib0033","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.celrep.2017.02.004","article-title":"\u03b2-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares","volume":"18","author":"Goldberg","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.nut.2025.112792_bib0034","first-page":"211","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science (1979)"},{"key":"10.1016\/j.nut.2025.112792_bib0035","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2021.04.004","article-title":"KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease","volume":"33","author":"Mori","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0036","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cmet.2020.06.020","article-title":"SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition","volume":"32","author":"Tomita","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0037","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tem.2019.01.006","article-title":"Anticatabolic effects of ketone bodies in skeletal muscle","volume":"30","author":"Koutnik","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0038","first-page":"3059","article-title":"Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice","volume":"119","author":"Hu","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2025.112792_bib0039","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cmet.2011.01.001","article-title":"Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle","volume":"13","author":"Shimizu","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.nut.2025.112792_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2020.101345","article-title":"\u03b2-hydroxybutyrate antagonizes aortic endothelial injury by promoting generation of VEGF in diabetic rats","volume":"64","author":"Wu","year":"2020","journal-title":"Tissue Cell"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900725001108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900725001108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:44:06Z","timestamp":1778546646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900725001108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":40,"alternative-id":["S0899900725001108"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2025.112792","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-hydroxybutyrate attenuates diabetic renal and muscular pathologies in a streptozotocin-induced diabetic model","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2025.112792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112792"}}