{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:49:19Z","timestamp":1785304159739,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD115191"],"award-info":[{"award-number":["R21HD115191"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.nut.2025.112857","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T06:03:20Z","timestamp":1748671400000},"page":"112857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Individuals with Down syndrome possess lower handgrip strength, appendicular lean mass, and muscle quality versus weight-matched adults"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3441-0706","authenticated-orcid":false,"given":"Ayush","family":"Mehra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-7045","authenticated-orcid":false,"given":"Ronald L.","family":"Snarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2167-1353","authenticated-orcid":false,"given":"Angela R.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Justo","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-0491","authenticated-orcid":false,"given":"Elroy J.","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Esco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan A.","family":"Czerwinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett S.","family":"Nickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.nut.2025.112857_bib0001","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.3390\/jcm10204687","article-title":"Aging with Down syndrome\u2014where are we now and where are we going?","volume":"10","author":"Alldred","year":"2021","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0002","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40520-023-02680-9","article-title":"Body composition parameters and sarcopenia in adults with Down syndrome: a case\u2013control study","volume":"36","author":"Villani","year":"2024","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.nut.2025.112857_bib0003","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.exger.2019.01.028","article-title":"Sarcopenia-related parameters in adults with Down syndrome: a cross-sectional exploratory study","volume":"119","author":"Coelho-Junior","year":"2019","journal-title":"Exp Gerontol"},{"issue":"3","key":"10.1016\/j.nut.2025.112857_bib0004","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jir.13107","article-title":"Functional fitness of adults with Down syndrome: a longitudinal study","volume":"68","author":"Boer","year":"2024","journal-title":"J Intellect Disabil Res"},{"issue":"11","key":"10.1016\/j.nut.2025.112857_bib0005","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1111\/j.1532-5415.2010.03145.x","article-title":"Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the concord health and ageing in men project","volume":"58","author":"Hairi","year":"2010","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0006","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jcsm.13397","article-title":"Association of low muscle mass and obesity with increased all-cause and cardiovascular disease mortality in US adults","volume":"15","author":"Kim","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12603-012-0004-5","article-title":"How to assess functional status: a new muscle quality index","volume":"16","author":"Barbat-Artigas","year":"2012","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.nut.2025.112857_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.706699","article-title":"Skeletal muscle quality: a biomarker for assessing physical performance capabilities in young populations","volume":"12","author":"Naimo","year":"2021","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.nut.2025.112857_bib0009","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/jcsm.12610","article-title":"Normative values of muscle strength across ages in a \u2018real world\u2019 population: results from the longevity check-up 7+ project","volume":"11","author":"Landi","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0010","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.nut.2025.112857_bib0011","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF02982704","article-title":"Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives","volume":"12","author":"Rolland","year":"2008","journal-title":"J Nutr Health Aging"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/mus.1215","article-title":"Aging of the human neuromuscular system","volume":"25","author":"Vandervoort","year":"2002","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nut.2025.112857_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112655","article-title":"A descriptive analysis of sarcopenia markers in young adults with Down syndrome","volume":"199","author":"Nickerson","year":"2025","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.nut.2025.112857_bib0014","series-title":"ACSM\u2019s health-related physical fitness assessment manual, 5e","author":"Liguori","year":"2018"},{"issue":"3","key":"10.1016\/j.nut.2025.112857_bib0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/1467-8721.ep10768783","article-title":"Statistical power analysis","volume":"1","author":"Cohen","year":"1992","journal-title":"Curr Dir Psychol Sci"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0016","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1037\/a0024338","article-title":"Effect size estimates: current use, calculations, and interpretation","volume":"141","author":"Fritz","year":"2012","journal-title":"J Exp Psychol Gen"},{"issue":"1","key":"10.1016\/j.nut.2025.112857_bib0017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1249\/MSS.0b013e31818cb278","article-title":"Progressive statistics for studies in sports medicine and exercise science","volume":"41","author":"Hopkins","year":"2009","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"10.1016\/j.nut.2025.112857_bib0018","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00223-013-9830-7","article-title":"Total and appendicular lean mass reference ranges for Australian men and women: the Geelong Osteoporosis Study","volume":"94","author":"Gould","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.nut.2025.112857_bib0019","doi-asserted-by":"crossref","first-page":"101014","DOI":"10.1016\/j.jshs.2024.101014","article-title":"International norms for adult handgrip strength: a systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions","volume":"14","author":"Tomkinson","year":"2025","journal-title":"J Sport Health Sci"},{"issue":"suppl 1","key":"10.1016\/j.nut.2025.112857_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00031305.2019.1583913","article-title":"Moving to a world beyond \u201c p < 0.05","volume":"73","author":"Wasserstein","year":"2019","journal-title":"Am Stat"},{"issue":"12","key":"10.1016\/j.nut.2025.112857_bib0021","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/jir.12959","article-title":"Field-based versus laboratory-based estimates of muscle quality index in adolescents with and without Down syndrome","volume":"66","author":"Melo","year":"2022","journal-title":"J Intellect Disabil Res"},{"issue":"5","key":"10.1016\/j.nut.2025.112857_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197711","article-title":"Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model","volume":"13","author":"Bala","year":"2018","journal-title":"PLOS ONE"},{"issue":"6","key":"10.1016\/j.nut.2025.112857_bib0023","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrendo.2009.80","article-title":"Endocrine and musculoskeletal abnormalities in patients with Down syndrome","volume":"5","author":"Hawli","year":"2009","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.nut.2025.112857_bib0024","doi-asserted-by":"crossref","first-page":"pzab032","DOI":"10.1093\/ptj\/pzab032","article-title":"Promoting participation in physical activity in children and adolescents with Down syndrome","volume":"101","author":"Wentz","year":"2021","journal-title":"Phys Ther"},{"issue":"4","key":"10.1016\/j.nut.2025.112857_bib0025","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/healthcare11040482","article-title":"Swimmers with Down syndrome are healthier and physically fit than their untrained peers","volume":"11","author":"Querido","year":"2023","journal-title":"Healthcare"},{"issue":"6","key":"10.1016\/j.nut.2025.112857_bib0026","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.clnu.2022.04.026","article-title":"Sex and population-specific cutoff values of muscle quality index: results from NHANES 2011\u20132014","volume":"41","author":"Lopes","year":"2022","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.nut.2025.112857_bib0027","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.annepidem.2016.07.006","article-title":"The muscle quality index and mortality among males and females","volume":"26","author":"Brown","year":"2016","journal-title":"Ann Epidemiol"},{"issue":"12","key":"10.1016\/j.nut.2025.112857_bib0028","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41430-024-01484-y","article-title":"Muscle quality index comparisons between Hispanics and non-Hispanic Caucasians using dual energy X-ray absorptiometry and handgrip strength","volume":"78","author":"Mehra","year":"2024","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"10.1016\/j.nut.2025.112857_bib0029","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1017\/S000711452400076X","article-title":"Comparisons between dual-energy X-ray absorptiometry and bioimpedance devices for appendicular lean mass and muscle quality in Hispanic adults","volume":"131","author":"Nassar","year":"2024","journal-title":"Br J Nutr"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900725001753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900725001753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:49:44Z","timestamp":1778762984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900725001753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"alternative-id":["S0899900725001753"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2025.112857","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individuals with Down syndrome possess lower handgrip strength, appendicular lean mass, and muscle quality versus weight-matched adults","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2025.112857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112857"}}