{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:16:15Z","timestamp":1785942975995,"version":"3.56.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFD195"],"award-info":[{"award-number":["2024AFD195"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nut.2026.113297","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:08:51Z","timestamp":1781680131000},"page":"113297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Enteral branched-chain amino acid delivery and weaning outcomes in critically ill patients with hypoalbuminemia: a cohort study"],"prefix":"10.1016","volume":"150","author":[{"given":"Jian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.nut.2026.113297_bib0001","first-page":"772","article-title":"Outcomes in critically ill patients after diaphragmatic stimulation on ventilator-induced diaphragmatic dysfunction: a systematic review","volume":"59","author":"Panelli","year":"2023","journal-title":"Eur J Phys Rehabil Med"},{"issue":"9","key":"10.1016\/j.nut.2026.113297_bib0002","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18259","article-title":"Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK","volume":"28","author":"Zhang","year":"2024","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.nut.2026.113297_bib0003","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.2147\/IDR.S383818","article-title":"Albumin infusion may improve the prognosis of critical COVID-19 patients with hypoalbuminemia in the intensive care unit: a retrospective cohort study","volume":"15","author":"Zhang","year":"2022","journal-title":"Infect Drug Resist"},{"issue":"19","key":"10.1016\/j.nut.2026.113297_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194002","article-title":"Oral branched-chain amino acids supplementation in athletes: a systematic review","volume":"14","author":"Martinho","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.nut.2026.113297_bib0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0954422423000197","article-title":"The effects of branched-chain amino acids on muscle protein synthesis, muscle protein breakdown and associated molecular signalling responses in humans: an update","volume":"37","author":"Kaspy","year":"2024","journal-title":"Nutr Res Rev"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0006","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00726-024-03417-2","article-title":"Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production","volume":"56","author":"Reifenberg","year":"2024","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.nut.2026.113297_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093106","article-title":"Branched-chain amino acids can predict mortality in ICU sepsis patients","volume":"13","author":"Reisinger","year":"2021","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.nut.2026.113297_bib0008","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.clnu.2023.07.011","article-title":"ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit","volume":"42","author":"Singer","year":"2023","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nut.2026.113297_bib0009","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.clnesp.2023.06.033","article-title":"Implementation of the ESPEN guideline on clinical nutrition in the intensive care unit (ICU): it is time to move forward!: a position paper from the \u2018nutrition in the ICU\u2019 ESPEN special interest group","volume":"57","author":"Thibault","year":"2023","journal-title":"Clin Nutr ESPEN"},{"issue":"8","key":"10.1016\/j.nut.2026.113297_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082851","article-title":"Nutrition in the intensive care unit-a narrative review","volume":"13","author":"Hill","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0011","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12937-024-01041-0","article-title":"Early intravenous branched-chain amino acid-enriched nutrition supplementation in older patients undergoing gastric surgery: a randomized clinical trial","volume":"23","author":"Ma","year":"2024","journal-title":"Nutr J"},{"issue":"12","key":"10.1016\/j.nut.2026.113297_bib0012","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.clnu.2023.09.026","article-title":"High protein provision of more than 1.2 g\/kg improves muscle mass preservation and mortality in ICU patients: a systematic review and meta-analyses","volume":"42","author":"van Ruijven","year":"2023","journal-title":"Clin Nutr"},{"issue":"7624","key":"10.1016\/j.nut.2026.113297_bib0013","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.nut.2026.113297_bib0014","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.medcli.2020.12.018","article-title":"Hypoalbuminemia on admission in COVID-19 infection: an early predictor of mortality and adverse events. a retrospective observational study","volume":"156","author":"Viana-Llamas","year":"2021","journal-title":"Med Clin (Barc)"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","article-title":"ESPEN guideline on clinical nutrition in the intensive care unit","volume":"38","author":"Singer","year":"2019","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.nut.2026.113297_bib0016","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1172\/JCI108201","article-title":"Leucine: a possible regulator of protein turnover in muscle","volume":"56","author":"Buse","year":"1975","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.nut.2026.113297_bib0017","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1007\/s00134-020-06176-2","article-title":"Successful spontaneous breathing trial, early reintubation and mechanisms of weaning failure","volume":"46","author":"Sanfilippo","year":"2020","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0018","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s13054-021-03802-3","article-title":"Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis","volume":"25","author":"Torrini","year":"2021","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0019","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s13054-016-1479-y","article-title":"Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index","volume":"20","author":"Spadaro","year":"2016","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.nut.2026.113297_bib0020","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s00134-015-3687-3","article-title":"Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity","volume":"41","author":"Goligher","year":"2015","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.nut.2026.113297_bib0021","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.emc.2014.07.011","article-title":"Critical care ultrasonography","volume":"32","author":"Peterson","year":"2014","journal-title":"Emerg Med Clin North Am"},{"issue":"10","key":"10.1016\/j.nut.2026.113297_bib0022","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.nut.2026.113297_bib0023","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \u201csepsis-related problems\u201d of the European Society of Intensive Care Medicine","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.nut.2026.113297_bib0024","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/sim.4780080504","article-title":"Flexible regression models with cubic splines","volume":"8","author":"Durrleman","year":"1989","journal-title":"Stat Med"},{"issue":"4 Suppl","key":"10.1016\/j.nut.2026.113297_bib0025","doi-asserted-by":"crossref","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies","volume":"65","author":"Willett","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.nut.2026.113297_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/nu15051086","article-title":"Medical nutrition therapy in critically ill patients with COVID-19-a single-center observational study","volume":"15","author":"Krzych","year":"2023","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.nut.2026.113297_bib0027","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jpen.1449","article-title":"The effect of higher protein dosing in critically ill patients: a multicenter registry-based randomized trial: the EFFORT trial","volume":"43","author":"Heyland","year":"2019","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"19","key":"10.1016\/j.nut.2026.113297_bib0028","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJMoa1811687","article-title":"Energy-dense versus routine enteral nutrition in the critically ill","volume":"379","author":"Chapman","year":"2018","journal-title":"N Engl J Med"},{"issue":"10116","key":"10.1016\/j.nut.2026.113297_bib0029","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(17)32146-3","article-title":"Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)","volume":"391","author":"Reignier","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0030","first-page":"61","article-title":"Amino acid kinetics in the critically ill","volume":"27","author":"Deutz","year":"2024","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.nut.2026.113297_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnesp.2025.11.153","article-title":"High leucine branched-chain amino acids supplementation ameliorates quadriceps femoris muscle thickness reduction and attenuates interleukin-6 in critically ill patients: a randomised controlled trial","volume":"72","author":"Wulandari","year":"2026","journal-title":"Clin Nutr ESPEN"},{"issue":"1 Suppl","key":"10.1016\/j.nut.2026.113297_bib0032","doi-asserted-by":"crossref","first-page":"227s","DOI":"10.1093\/jn\/136.1.227S","article-title":"Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis","volume":"136","author":"Kimball","year":"2006","journal-title":"J Nutr"},{"issue":"4","key":"10.1016\/j.nut.2026.113297_bib0033","first-page":"738","article-title":"Risk factors for mechanical ventilation in patients with severe multiple trauma","volume":"52","author":"Guo","year":"2020","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0034","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-020-0168-0","article-title":"Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth","volume":"5","author":"Lei","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.nut.2026.113297_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1550-2783-9-20","article-title":"Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study","volume":"9","author":"Howatson","year":"2012","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"10.1016\/j.nut.2026.113297_bib0036","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jpen.1451","article-title":"Hypoalbuminemia: pathogenesis and clinical significance","volume":"43","author":"Soeters","year":"2019","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"11","key":"10.1016\/j.nut.2026.113297_bib0037","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpedi.161.11.1048","article-title":"Hypoalbuminemia in critically ill children","volume":"161","author":"Horowitz","year":"2007","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"10.1016\/j.nut.2026.113297_bib0038","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00421-020-04354-0","article-title":"Caloric restriction induces anabolic resistance to resistance exercise","volume":"120","author":"Murphy","year":"2020","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"10.1016\/j.nut.2026.113297_bib0039","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12986-025-01053-5","article-title":"Branched-chain amino acids and sepsis: from pathological mechanisms to clinical interventions","volume":"23","author":"Yang","year":"2025","journal-title":"Nutr Metab (Lond)"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726002054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726002054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:38:21Z","timestamp":1785940701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900726002054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0899900726002054"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2026.113297","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enteral branched-chain amino acid delivery and weaning outcomes in critically ill patients with hypoalbuminemia: a cohort study","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2026.113297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113297"}}