{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:18:42Z","timestamp":1785943122983,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nut.2026.113304","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:05:26Z","timestamp":1779807926000},"page":"113304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Perioperative immunonutrition reduces infections and hospital stay in older patients undergoing elective cardiac surgery"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-7917","authenticated-orcid":false,"given":"Thiago J.M.","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.A.B.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo M.","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe L.","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara S.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra A.S.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos P.","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos F.","family":"Berlinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2026.113304_bib0001","unstructured":"World Health Organization (WHO). Cardiovascular diseases (CVDs). 2021. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds). Accessed Dec 12, 2025"},{"issue":"1","key":"10.1016\/j.nut.2026.113304_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.nut.2026.113304_bib0003","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.atssr.2023.11.019","article-title":"Global cardiac surgical volume and gaps: trends, targets, and way forward","volume":"2","author":"Vervoort","year":"2024","journal-title":"Ann Thorac Surg Short Rep"},{"issue":"10","key":"10.1016\/j.nut.2026.113304_bib0004","article-title":"Enhanced recovery after surgery: exploring the advances and strategies","volume":"15","author":"Jain","year":"2023","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.nut.2026.113304_bib0005","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00268-021-05964-1","article-title":"Expert consensus of data elements for collection for enhanced recovery after cardiac surgery","volume":"45","author":"Hirji","year":"2021","journal-title":"World J Surg"},{"issue":"4","key":"10.1016\/j.nut.2026.113304_bib0006","doi-asserted-by":"crossref","first-page":"532","DOI":"10.5114\/ceji.2014.47741","article-title":"The immune response to surgery and infection","volume":"39","author":"D\u0105browska","year":"2014","journal-title":"Cent J Immunol"},{"issue":"8","key":"10.1016\/j.nut.2026.113304_bib0007","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/138945009788982432","article-title":"Immunonutrition in surgical patients","volume":"10","author":"Xu","year":"2009","journal-title":"Curr Drug Targets"},{"issue":"8","key":"10.1016\/j.nut.2026.113304_bib0008","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1067\/j.cpsurg.2019.04.003","article-title":"Advances in nutrition for the surgical patient","volume":"56","author":"Yeh","year":"2019","journal-title":"Curr Probl Surg"},{"issue":"4","key":"10.1016\/j.nut.2026.113304_bib0009","doi-asserted-by":"crossref","first-page":"85","DOI":"10.14797\/mdcvj.1248","article-title":"Optimizing nutritional status of patients prior to major surgical intervention","volume":"19","author":"Sanchez Leon","year":"2023","journal-title":"Methodist Debakey Cardiovasc J"},{"issue":"4","key":"10.1016\/j.nut.2026.113304_bib0010","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/10892532221130922","article-title":"Pre-habilitation of cardiac surgical patients, part 2: frailty, malnutrition, respiratory disease, alcohol\/smoking cessation and depression","volume":"26","author":"Subramanian","year":"2022","journal-title":"Semin Cardiothorac Vasc Anesth"},{"issue":"7","key":"10.1016\/j.nut.2026.113304_bib0011","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1016\/j.clnu.2021.03.031","article-title":"ESPEN practical guideline: clinical nutrition in surgery","volume":"40","author":"Weimann","year":"2021","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.nut.2026.113304_bib0012","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/bjs5.50314","article-title":"Impact of oral preoperative and perioperative immunonutrition on postoperative infection and mortality in patients undergoing cancer surgery: systematic review and meta-analysis with trial sequential analysis","volume":"4","author":"Buzquurz","year":"2020","journal-title":"BJS Open"},{"issue":"3","key":"10.1016\/j.nut.2026.113304_bib0013","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/SLA.0000000000006116","article-title":"Impact of perioperative immunonutrition on postoperative outcomes for patients undergoing head and neck or gastrointestinal cancer surgeries: a systematic review and meta-analysis of randomized controlled trials","volume":"279","author":"Matsui","year":"2024","journal-title":"Ann Surg"},{"issue":"9283","key":"10.1016\/j.nut.2026.113304_bib0014","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(01)05836-6","article-title":"Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial","volume":"358","author":"Tepaske","year":"2001","journal-title":"Lancet (Lond Engl)"},{"issue":"8","key":"10.1016\/j.nut.2026.113304_bib0015","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1007\/s00268-005-0657-x","article-title":"Postsurgical infections are reduced with specialized nutrition support","volume":"30","author":"Waitzberg","year":"2006","journal-title":"World J Surg"},{"issue":"4","key":"10.1016\/j.nut.2026.113304_bib0016","first-page":"387","article-title":"Impact of preoperative immunonutritional support in patients undergoing elective thoracic surgery","volume":"4","author":"Shoji","year":"2021","journal-title":"JMA J"},{"issue":"3","key":"10.1016\/j.nut.2026.113304_bib0017","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.amjsurg.2023.06.011","article-title":"The effect of preoperative oral nutritional supplementation on surgical site infections among adult patients undergoing elective surgery: a systematic review and meta-analysis","volume":"226","author":"Cadili","year":"2023","journal-title":"Am J Surg"},{"issue":"6","key":"10.1016\/j.nut.2026.113304_bib0018","doi-asserted-by":"crossref","first-page":"802","DOI":"10.21470\/1678-9741-2020-0219","article-title":"Is vasoactive-inotropic score a predictor for mortality and morbidity in patients undergoing coronary artery bypass surgery?","volume":"36","author":"Baysal","year":"2021","journal-title":"Braz J Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.nut.2026.113304_bib0019","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/ALN.0000000000000224","article-title":"Health outcomes with and without use of inotropic therapy in cardiac surgery: results of a propensity score-matched analysis","volume":"120","author":"Nielsen","year":"2014","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.nut.2026.113304_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/1806-9282.20221433","article-title":"24Th hour vasoactive inotrope score is associated with poor outcome in adult cardiac surgery","volume":"69","author":"Mete","year":"2023","journal-title":"Rev Assoc Med Bras"},{"issue":"6","key":"10.1016\/j.nut.2026.113304_bib0021","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/ALN.0b013e318173026f","article-title":"Perioperative use of dobutamine in cardiac surgery and adverse cardiac outcome","volume":"108","author":"Fellahi","year":"2008","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.nut.2026.113304_bib0022","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0022-5223(00)70138-3","article-title":"Sodium nitroprusside in patients with compromised left ventricular function undergoing coronary bypass: Reduction of cardiac proinflammatory substances","volume":"119","author":"Massoudy","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.nut.2026.113304_bib0023","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/anae.14506","article-title":"Pre-operative nutrition and the elective surgical patient: why, how and what?","volume":"74 Suppl 1","author":"Gillis","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.nut.2026.113304_bib0024","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/ALN.0000000000000795","article-title":"Promoting perioperative metabolic and nutritional care","volume":"123","author":"Gillis","year":"2015","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.nut.2026.113304_bib0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12885-023-10820-7","article-title":"The effect of immunonutrition in patients undergoing pancreaticoduodenectomy: a systematic review and meta-analysis","volume":"23","author":"Fan","year":"2023","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.nut.2026.113304_bib0026","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12957-024-03348-y","article-title":"Effect of preoperative immunonutrition on postoperative short-term clinical outcomes in patients with gastric cancer cachexia: a prospective randomized controlled trial","volume":"22","author":"Yu","year":"2024","journal-title":"World J Surg Oncol"},{"issue":"7","key":"10.1016\/j.nut.2026.113304_bib0027","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/jpen.2028","article-title":"Perioperative immunonutrition in elderly patients undergoing total hip and knee arthroplasty: impact on postoperative outcomes","volume":"45","author":"Gon\u00e7alves","year":"2021","journal-title":"JPEN J Parenter Enter Nutr"},{"issue":"1","key":"10.1016\/j.nut.2026.113304_bib0028","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12937-016-0153-1","article-title":"Multimodal perioperative care plus immunonutrition versus traditional care in total hip arthroplasty: a randomized pilot study","volume":"15","author":"Alito","year":"2016","journal-title":"Nutr J"},{"issue":"3","key":"10.1016\/j.nut.2026.113304_bib0029","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/nu15030537","article-title":"Immunonutrition in orthopedic and traumatic patients","volume":"15","author":"Gregori","year":"2023","journal-title":"Nutrients"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726002121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726002121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:40:09Z","timestamp":1785940809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900726002121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0899900726002121"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2026.113304","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perioperative immunonutrition reduces infections and hospital stay in older patients undergoing elective cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2026.113304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113304"}}