{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:05:33Z","timestamp":1789419933635,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.nut.2026.113404","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:03:33Z","timestamp":1787155413000},"page":"113404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Individualized medical nutrition therapy with weekly follow-up improves glycemic control, inflammation, and reduces circulating zonulin in adults with type 2 diabetes mellitus: a randomized controlled trial"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-2687","authenticated-orcid":false,"given":"Serap Balaban","family":"Barta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-9571","authenticated-orcid":false,"given":"Asl\u0131","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-2987","authenticated-orcid":false,"given":"Selen","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0042-6928","authenticated-orcid":false,"given":"Tugba","family":"Barlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-3771","authenticated-orcid":false,"given":"\u0130lhan","family":"Yetkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nut.2026.113404_bib0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2337\/cd22-as01","article-title":"Standards of medical care in diabetes\u20142022 abridged for primary care providers","volume":"40","year":"2022","journal-title":"Clin Diabetes"},{"key":"10.1016\/j.nut.2026.113404_bib0002","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/db16-0806","article-title":"Differentiation of diabetes by pathophysiology, natural history, and prognosis","volume":"66","author":"Skyler","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.nut.2026.113404_bib0003","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1902\/jop.2008.080246","article-title":"The role of inflammatory cytokines in diabetes and its complications","volume":"79","author":"King","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.nut.2026.113404_bib0004","series-title":"T\u00fcrkiye Beslenme Rehberi (T\u00dcBER) Ankara: Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131","year":"2022"},{"key":"10.1016\/j.nut.2026.113404_bib0005","series-title":"Krause\u2019s food & the nutrition care process","first-page":"586","article-title":"Medical nutrition therapy for diabetes mellitus and hypoglycemia of nondiabetic origin","author":"Marion","year":"2017"},{"key":"10.1016\/j.nut.2026.113404_bib0006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.nut.2026.113404_bib0007","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-013-1911-4","article-title":"Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes","volume":"388","author":"Jayashree","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nut.2026.113404_bib0008","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/dme.12360","article-title":"Increased intestinal permeability to oral chromium (51Cr)-EDTA in human type 2 diabetes","volume":"31","author":"Horton","year":"2014","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.nut.2026.113404_bib0009","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1210\/jc.2004-1963","article-title":"Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy","volume":"90","author":"Perego","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nut.2026.113404_bib0010","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nut.2026.113404_bib0011","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11010-011-0727-3","article-title":"Impaired miR-146a expression links subclinical inflammation and insulin resistance in type 2 diabetes","volume":"351","author":"Balasubramanyam","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nut.2026.113404_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037160","article-title":"Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance","volume":"7","author":"Moreno-Navarrete","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nut.2026.113404_bib0013","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2337\/db05-1593","article-title":"Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives","volume":"55","author":"Sapone","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.nut.2026.113404_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1073131","article-title":"Effects of an outpatient diabetes self-management education on patients with type 2 diabetes in China: a randomized controlled trial","volume":"2019","author":"Zheng","year":"2019","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.nut.2026.113404_bib0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2337\/diacare.17.4.267","article-title":"The evaluation of two measures of quality of life in patients with type I and type II diabetes","volume":"17","author":"Jacobson","year":"1994","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2026.113404_bib0016","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s11136-007-9172-x","article-title":"Translation, cultural adaptation, cross-validation of the Turkish diabetes quality-of-life (DQOL) measure","volume":"16","author":"Yildirim","year":"2007","journal-title":"Qual Life Res"},{"key":"10.1016\/j.nut.2026.113404_bib0017","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1111\/j.1365-2702.2010.03329.x","article-title":"Turkish validity and reliability of the summary of diabetes self-care activities measure for patients with type 2 diabetes mellitus","volume":"19","author":"Kav","year":"2010","journal-title":"J Clin Nurs"},{"key":"10.1016\/j.nut.2026.113404_bib0018","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2337\/diacare.23.7.943","article-title":"The summary of diabetes self-care activities measure: results from 7 studies and a revised scale","volume":"23","author":"Toobert","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2026.113404_bib0019","series-title":"A research on reliability and validity of international physical activity questionnaire and determination of physical activity level in university students","author":"\u00d6zt\u00fcrk","year":"2005"},{"key":"10.1016\/j.nut.2026.113404_bib0020","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.nut.2026.113404_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-8-419","article-title":"An overview on ELISA techniques for FMD","volume":"8","author":"Ma","year":"2011","journal-title":"Virol J"},{"key":"10.1016\/j.nut.2026.113404_bib0022","first-page":"8","volume":"2008","year":"2008"},{"key":"10.1016\/j.nut.2026.113404_bib0023","series-title":"Anthropometry procedures manual","year":"2009"},{"key":"10.1016\/j.nut.2026.113404_bib0024","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.clnu.2004.06.004","article-title":"Bioelectrical impedance analysis\u2014Part I: review of principles and methods","volume":"23","author":"Kyle","year":"2004","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nut.2026.113404_bib0025","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"10.1016\/j.nut.2026.113404_bib0026","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.jada.2010.09.014","article-title":"The evidence for medical nutrition therapy for type 1 and type 2 diabetes in adults","volume":"110","author":"Franz","year":"2010","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.nut.2026.113404_bib0027","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1464-5491.2011.03405.x","article-title":"Effectiveness of medical nutrition treatment delivered by dietitians on glycaemic outcomes and lipid profiles of Arab, Omani patients with type 2 diabetes","volume":"29","author":"Al-Shookri","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.nut.2026.113404_bib0028","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.nut.2026.113404_bib0029","series-title":"Yemek ve Besin Foto\u011fraf Katalo\u011fu: \u00d6l\u00e7\u00fc ve Miktarlar, yenilenmi\u015f","author":"Rakicio\u011flu","year":"2012"},{"key":"10.1016\/j.nut.2026.113404_bib0030","series-title":"Data Bases: Bundeslebenmittelschl\u00fcssell, 11.3 and Other Sources","article-title":"Ebispro for Windows","year":"2020"},{"key":"10.1016\/j.nut.2026.113404_bib0031","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1900\/RDS.2007.4.226","article-title":"Effectiveness of an intensive nutritional intervention in patients with type 2 diabetes mellitus: results from a pilot study","volume":"4","author":"Yannakoulia","year":"2008","journal-title":"Rev Diabet Stud: RDS"},{"key":"10.1016\/j.nut.2026.113404_bib0032","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.beem.2005.07.010","article-title":"Link between obesity and type 2 diabetes","volume":"19","author":"Golay","year":"2005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.nut.2026.113404_bib0033","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.2337\/dc22-0338","article-title":"Lifestyle intervention strategy to treat diabetes in older adults: a randomized controlled trial","volume":"45","author":"Celli","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2026.113404_bib0034","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2337\/dc15-1942","article-title":"Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders","volume":"39","author":"Steven","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nut.2026.113404_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107766","article-title":"Impaired intestinal barrier function in type 2 diabetic patients measured by serum LPS, zonulin, and IFABP","volume":"35","author":"Yuan","year":"2021","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.nut.2026.113404_bib0036","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pcd.2022.03.007","article-title":"Effectiveness of restricted diet with a plate in patients with type 2 diabetes: a randomized controlled trial","volume":"16","author":"Zhang","year":"2022","journal-title":"Prim Care Diabetes"},{"key":"10.1016\/j.nut.2026.113404_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/789761","article-title":"The effect of diabetes self-management education on body weight, glycemic control, and other metabolic markers in patients with type 2 diabetes mellitus","volume":"2014","author":"Yuan","year":"2014","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.nut.2026.113404_bib0038","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.ijnurstu.2008.04.005","article-title":"Concept analysis: self-monitoring in type 2 diabetes mellitus","volume":"45","author":"Song","year":"2008","journal-title":"Int J Nurs Stud"},{"key":"10.1016\/j.nut.2026.113404_bib0039","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.colegn.2015.09.005","article-title":"Self-efficacy, depression and self-care activities of people with type 2 diabetes in Turkey","volume":"24","author":"Kav","year":"2017","journal-title":"Collegian"},{"key":"10.1016\/j.nut.2026.113404_bib0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jand.2018.06.303","volume":"119","author":"Marincic","year":"2019","journal-title":"J Acad Nutr Diet"},{"key":"10.1016\/j.nut.2026.113404_bib0041","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s40200-020-00567-4","article-title":"Effects of therapeutic education on self-efficacy, self-care activities and glycemic control of type 2 diabetic patients in a primary healthcare center in Lebanon","volume":"19","author":"ElGerges","year":"2020","journal-title":"J Diabetes Metab Disord"},{"key":"10.1016\/j.nut.2026.113404_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12955-016-0411-0","article-title":"Estimating the impact of changes in HbA 1c, body weight and insulin injection regimen on health related quality-of-life: a time trade off study","volume":"14","author":"Ridderstr\u00e5le","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.nut.2026.113404_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7525-6-87","article-title":"Evaluating the reliability, validity and minimally important difference of the Taiwanese version of the diabetes quality of life (DQOL) measurement","volume":"6","author":"Huang","year":"2008","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.nut.2026.113404_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5076858","article-title":"Elevated serum TNF-\u03b1 is related to obesity in type 2 diabetes mellitus and is associated with glycemic control and insulin resistance","volume":"2020","author":"Alzamil","year":"2020","journal-title":"J Obes"},{"key":"10.1016\/j.nut.2026.113404_bib0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4274\/tjo.galenos.2022.70375","article-title":"An association between the intestinal permeability biomarker zonulin and the development of diabetic retinopathy in type II diabetes mellitus","volume":"53","author":"Erdem","year":"2023","journal-title":"Turk J Ophthalmol"},{"issue":"1","key":"10.1016\/j.nut.2026.113404_bib0046","first-page":"1","article-title":"Regulation of serum lipid profile, glucose, insulin, and adiponectin in obese diabetic women under diet therapy: a randomized clinical controlled study","volume":"19","author":"Mohammadi","year":"2017","journal-title":"Iran Red Crescent Med J"},{"key":"10.1016\/j.nut.2026.113404_bib0047","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.diabres.2014.08.017","article-title":"Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients","volume":"106","author":"Zhang","year":"2014","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726003114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899900726003114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:32:35Z","timestamp":1789417955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899900726003114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":47,"alternative-id":["S0899900726003114"],"URL":"https:\/\/doi.org\/10.1016\/j.nut.2026.113404","relation":{},"ISSN":["0899-9007"],"issn-type":[{"value":"0899-9007","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individualized medical nutrition therapy with weekly follow-up improves glycemic control, inflammation, and reduces circulating zonulin in adults with type 2 diabetes mellitus: a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nut.2026.113404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113404"}}